2017 Fiscal Year Final Research Report
Role of a novel B-1 cell subset in anti-inflammatory processes
| Project/Area Number |
16K21107
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
Biological pharmacy
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 免疫 / B細胞 / B-1細胞 / IL-10 |
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| Outline of Final Research Achievements |
SPA-1 is a specific negative regulator of Rap1 that mediates broad cellular activities. Because our preliminary results suggest that SPA-1 knockout mice show a lack of a novel B-1 cell subset that acts as anti-inflammatory properties, we investigated the role of the cell subset in anti-inflammatory processes. The new B-1 cell subset isolated from WT cells produced a large amount of an anti-inflammatory cytokine IL-10. In this cell subset, the expression levels of integrin and PD-L2 were higher whereas B cell differentiation-related transcription factors tended to be lower than other cell subsets. Furthermore, this cell subset was not present in young WT mice. These findings suggest that SPA-1 regulates the differentiation of novel B-1 cell subset which has anti-inflammatory function.
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| Free Research Field |
免疫学
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