2017 Fiscal Year Final Research Report
Novel theranostic strategy against peritoneal metastasis of gastric cancer
| Project/Area Number |
16K21185
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
ISHIKAWA Wataru
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 胃癌 / 腹膜播種 / 腹腔内投与 / 腫瘍溶解ウイルス / パクリタキセル |
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| Outline of Final Research Achievements |
We investigated the efficacy of combination therapy using oncolytic adenovirus; OBP-401 which could replicate only within the tumor cells selectively and express green fluorescent protein (GFP) and chemotherapeutic agent, paclitaxel (PTX). OBP-401 synergistically suppressed the viability of two kinds of human SGC cells in combination with PTX in vitro. And PTX enhanced the efficacy of OBP-401 replication, resulted in synergistic effect. Peritoneal metastatic cells were visualized as GFP-positive cells selectively by the intra-peritoneal (i.p.) administration of OBP-401 in the orthotopic mouse model. The combination therapy with i.p. administration of OBP-401 and PTX could also significantly inhibited the tumor growth in vivo.
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| Free Research Field |
消化器外科
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