2017 Fiscal Year Final Research Report
The role of retinoic acd signaling in endochondral ossification
| Project/Area Number |
16K21186
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Morphological basic dentistry
Dental engineering/Regenerative dentistry
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
Uchibe Kenta 岡山大学, 医歯薬学総合研究科, 助教 (20584618)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | レチノイン酸 / 軟骨内骨化 |
|---|
| Outline of Final Research Achievements |
We performed in vitro and in vivo experiments to understand the role of retinoic acid signaling in endochondral ossification. Stimulation of RARγ signaling inhibited chondrocyte differentiation. Pharmacological inhibition of RARγ stimulated endochondral ossification both in vitro and in vivo, resulting in enhanced bone formation. Variety of signaling molecules are found to be involved in this process.
|
| Free Research Field |
解剖学
|
