Molecular mechanism of mammalian determination by histone modification

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21196
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science; Genome biology
• Research Institution: The University of Tokushima
• Principal Investigator: KUROKI Shunsuke 徳島大学, 先端酵素学研究所(次世代), 助教 (50735793)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 性決定

Outline of Final Research Achievements

Development and differentiation is based on the precise control of gene expression. Epigenetic control by histone modifications and DNA methylation is indispensable for the spatio-temporal proper gene expression. We previously reported that Jmjd1a, one of the histone demethylases, plays a critical role for the expression of sex determination gene Sry in mouse embryos. For further knowledge of "the mammalian sex determinetion controlled by the epigenome", we have perfomed the following two projects, 1) Revealing the cooperative epigenetic control of Sry locus by H3K9 demethylase Jmjd1 family, 2) Searching for novel regulators for Sry locus.

Free Research Field

分子生物学