2018 Fiscal Year Final Research Report
The protective effects of fecal microbiota transplantation in a rat model of necrotizing enterocolitis.
| Project/Area Number |
16K21204
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Embryonic/Neonatal medicine
Bacteriology (including mycology)
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
Tanaka Aya
Katami Hiroto
Chiba Yoichi
Ueno Masaki
Imaohji Haruyuki
Kuwahara Tomomi
Onishi Shun
Kaji Tatsuru
Ieiri Satoshi
Miki Takanori
Shimono Ryuichi
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Keywords | 壊死性腸炎 / 短腸症候群 / Dysbiosis / 腸内細菌 |
|---|
| Outline of Final Research Achievements |
We investigated whether partially hydrolyzed guar gum ameliorates small intestinal mucosal damage and alters the intestinal microbiota using a rat small bowel resection (SBR) model.The mucosal degeneration rate was significantly higher in the SBR group. Partially hydrolyzed guar gum administration alleviated small intestinal mucosal damage, which could be associated with modulation of the intestinal microbiota.
|
| Free Research Field |
小児外科学
|
| Academic Significance and Societal Importance of the Research Achievements |
新生児壊死性腸炎の重篤な合併症に短腸症候群がある。短腸症候群では腸管粘膜の萎縮や透過性の亢進から、腸内菌共生バランス失調を招き更なる合併症を引き起こすため、腸内環境の是正が重要である。食物繊維のグアーガムを用いることで小腸の粘膜が抑制され、腸内細菌叢の異常が是正される可能性を示した。このことは短腸症候群における新たな治療戦略の確立に寄与すると考えられる。
|
