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2018 Fiscal Year Final Research Report

The protective effects of fecal microbiota transplantation in a rat model of necrotizing enterocolitis.

Research Project

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Project/Area Number 16K21204
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Bacteriology (including mycology)
Research InstitutionKagawa University

Principal Investigator

Fujii Takayuki  香川大学, 医学部, 助教 (00746696)

Research Collaborator Tanaka Aya  
Katami Hiroto  
Chiba Yoichi  
Ueno Masaki  
Imaohji Haruyuki  
Kuwahara Tomomi  
Onishi Shun  
Kaji Tatsuru  
Ieiri Satoshi  
Miki Takanori  
Shimono Ryuichi  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords壊死性腸炎 / 短腸症候群 / Dysbiosis / 腸内細菌
Outline of Final Research Achievements

We investigated whether partially hydrolyzed guar gum ameliorates small intestinal mucosal damage and alters the intestinal microbiota using a rat small bowel resection (SBR) model.The mucosal degeneration rate was significantly higher in the SBR group. Partially hydrolyzed guar gum administration alleviated small intestinal mucosal damage, which could be associated with modulation of the intestinal microbiota.

Free Research Field

小児外科学

Academic Significance and Societal Importance of the Research Achievements

新生児壊死性腸炎の重篤な合併症に短腸症候群がある。短腸症候群では腸管粘膜の萎縮や透過性の亢進から、腸内菌共生バランス失調を招き更なる合併症を引き起こすため、腸内環境の是正が重要である。食物繊維のグアーガムを用いることで小腸の粘膜が抑制され、腸内細菌叢の異常が是正される可能性を示した。このことは短腸症候群における新たな治療戦略の確立に寄与すると考えられる。

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Published: 2020-03-30  

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