Nanotechnology to facilitate bone tissue regeneration through polarization of macrophage phenotype

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21212
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry; Prosthodontics/ Dental materials science and
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Riki Toita 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (40611554)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 再生医療 / 炎症 / マクロファージ / 硬組織インプラント / ナノメディシン

Outline of Final Research Achievements

Osteogenesis of mesenchymal stem cells was activated through increasing surface hydrophilicity and surface roughness of titanium and PEEK. Increase in hydrophilicity of biomaterilas reduced inflammatory responses of macrophage, whereas surface roughness did not. Nanoparticles (NPs) possessing anti-inflammatory activity can be modified on titanium using a layer-by-layer method. Interestingly, titanium modified with NPs can polarize M1 type macrophage to M2 type which enhances osteogenesis of MSCs and pre-osteoblasts through growth factors. In animal experiments, the modified titanium facilitated new bone formation when compared with pristine titanium. In summary, we can develop new method to increase osseointegration activity of titanium implant through changing macrophage phenotype.

Free Research Field

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