2017 Fiscal Year Annual Research Report
Stimulating the host innate immune response to fight the early stages of malaria infection
| Project/Area Number |
16K21233
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| Research Institution | Nagasaki University |
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Principal Investigator |
カレトン リチャード 長崎大学, 熱帯医学研究所, 准教授 (10503782)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | Malaria / Pam2Cys / vaccine / antimalarial drug |
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| Outline of Annual Research Achievements |
During the last year we analysed how Pam2Cys changes the immune system to protect against malaria parasites in the livers of mice. We found that:
1) Pam2Cys increased blood levels of cytokines, small proteins that effect other cells. It is possible that increased levels of cytokines are involved in killing malaria parasites in the liver.
2) Pam2Cys increased the numbers of Natural Killer (NK) T-cells in the livers of mice. These NK T-cells may be activated by cytokines.
3) Pam2Cys protects the liver against malaria parasite growth at concentrations of 5 nanomoles.
While more work needs to be done to explain exactly how Pam2Cys changes the immune system, our research shows that Pam2Cys both kills parasites and prevents infection in the livers of mice.
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Research Products
(9 results)
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[Journal Article] An assay for the identification of Plasmodium simium infection for diagnosis of zoonotic malaria in the Brazilian Atlantic Forest2018
Author(s)
Alvarenga DA, Culleton R, Pina-Costa Ad, Rodrigues D, Junior CB, Silva S, Nunes AJ, J Souza jr JCd, Hirano Z, Moreira ZB, Pissinatti A, Abreu F, Areas AL, Lourenco-de-Oliveira R, Zalis MG, Brasil P, Ferreira-da-Cruz MdF, Daniel-Ribeiro CT, Alves de Brito CF
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Journal Title
Scientific Reports
Volume: 8
Pages: e18216
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: a molecular epidemiological investigation2017
Author(s)
Brasil P, Zalis M G, de Pina-Costa A, Siqueira AM, Bianco Junior C, Silva S, Areas ALL, Pelajo-Machado M, de Alvarenga DAM, Santelli ACFdS, Albuquerque HG, Cravo P, de Abreu FVS, Peterka CL, Zanini GM, Suarez-Mutis MC, Pissinatti A, Lourenco-de-Oliveira R, Brito CFAd, Ferreira-da-Cruz MdF, Culleton R, Daniel-Ribeiro CT
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Journal Title
The Lancet Global Health
Volume: 5
Pages: e1038～e1046
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Rapid identification of genes controlling virulence and immunity in malaria parasites2017
Author(s)
Abkallo H, Martinelli A, Inoue M, Ramaprasad A, Xangsayarath P, Gitaka J, Tang J, Yahata K, Zoungrana A, Mitaka H, Hunt P, Carter R, Kaneko O, Mustonen V, Illingworth CJR, Pain A, Culleton R
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Journal Title
PLOS Pathogens
Volume: 13
Pages: e1006447
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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