Regulation of PirB, a receptor causing neurodegenerative diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21268
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology; General pharmacology
• Research Institution: Yokohama City University
• Principal Investigator: KURIHARA Yuji 横浜市立大学, 生命医科学研究科, 特任助教 (00634552)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 神経科学 / 薬理学 / 神経疾患 / 受容体制御

Outline of Final Research Achievements

Paired immunoglobulin-like receptor B (PirB) is a novel functional receptor for oligomerized beta-amyloid impairing cognitive and memory function in Alzheimer’s disease. I examined the regulation of the molecular function of PirB bound by oligomerized beta-amyloid. I found that LOTUS interacts with PirB. Furthermore, overexpression of LOTUS with PirB in COS7 cells blocked the binding of oligomerized beta-amyloid to PirB. Moreover, an antibody against PirB also interfered with the binding of oligomerized beta-amyloid to PirB overexpressed in COS7 cells. These data suggest that LOTUS or the antibody might inhibit the physiological function of PirB induced by oligomerized beta-amyloid.

Free Research Field

神経薬理学