2017 Fiscal Year Final Research Report
Regulation of PirB, a receptor causing neurodegenerative diseases
Project/Area Number |
16K21268
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
General pharmacology
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Research Institution | Yokohama City University |
Principal Investigator |
KURIHARA Yuji 横浜市立大学, 生命医科学研究科, 特任助教 (00634552)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | 神経科学 / 薬理学 / 神経疾患 / 受容体制御 |
Outline of Final Research Achievements |
Paired immunoglobulin-like receptor B (PirB) is a novel functional receptor for oligomerized beta-amyloid impairing cognitive and memory function in Alzheimer’s disease. I examined the regulation of the molecular function of PirB bound by oligomerized beta-amyloid. I found that LOTUS interacts with PirB. Furthermore, overexpression of LOTUS with PirB in COS7 cells blocked the binding of oligomerized beta-amyloid to PirB. Moreover, an antibody against PirB also interfered with the binding of oligomerized beta-amyloid to PirB overexpressed in COS7 cells. These data suggest that LOTUS or the antibody might inhibit the physiological function of PirB induced by oligomerized beta-amyloid.
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Free Research Field |
神経薬理学
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