2017 Fiscal Year Annual Research Report
Identifying the Role of Cell Polarity in 'Real-Time' during Epithelial Homeostasis
| Project/Area Number |
16K21272
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| Research Institution | Yokohama City University |
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Principal Investigator |
Goulas Spyros 横浜市立大学, 先端医科学研究センター, 特任助教 (90644352)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | Cell Polarity / Epithelial Homeostasis / Cell Death / Barrier Malfunction |
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| Outline of Annual Research Achievements |
In FY2017, I characterized the candidates identified from the knockdown screen of cell polarity regulators during epithelial homeostasis. I identified a group of genes that resulted in defects at cell-cell contact sites specifically during cell death. Interestingly, this was accompanied by a transient increases in the integrity of the epithelium. I was able to identify the downstream molecular targets, thereby giving insights into the molecular mechanism of how epithelia maintain barrier function during homeostasis.
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[Journal Article] Oral ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin2017
Author(s)
Yazaki, M., Ito, Y., Yamada, M., Goulas, S., Teramoto, S., Nakaya, M., Ohno, S. & Yamaguchi, K.
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Journal Title
Journal of Agricultural and Food Chemistry
Volume: 65
Pages: 2315-2322
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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