Apatite nano coating improves biocompatibility and osteogenic ability of artificial ligament

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K21291
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery; Sports science
• Research Institution: Nara Medical University
• Principal Investigator: Inagaki Yusuke 奈良県立医科大学, 医学部, 助教 (60707529)
• Research Collaborator: Akahane Manabu ; Furukawa Akira ; Egawa Takuya ; Ogawa Munehiro ; Kawate Kenji ; Tanaka Yasuhito
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: ナノコーティング / スチロンチウム / ケイ素 / 人工靭帯 / 骨形成

Outline of Final Research Achievements

Anterior cruciate ligament reconstruction (ACLR) using autologous tendon and polyethylene terephthalate (PET) artificial ligaments are widely performed.　In previous reports, hydroxyapatite (HAP) was coated on the surface of the artificial ligament to improve biocompatibility and osteogenic ability. As for the component of HAP, calcium can be substituted with strontium, and phosphate ion with silicate ions (SrSiP). In this study, the osteogenic abilities of rat bone marrow stromal cells (BMSCs) cultured on the surfaces of SrSiP nano coated PET film and artificial ligament were evaluated. BMSCs cultured on the SrSiP nano coated PET film and artificial ligament showed the highr osteogenic abilities. These findings indicate that PET artificial ligaments coated with SrSiP may be one of the future options to improve the clinical results of ACLR.

Free Research Field

整形外科学

Academic Significance and Societal Importance of the Research Achievements

膝前十字靱帯損傷は最も頻度の高いスポーツ外傷のひとつであり、靭帯再建術においては移植材料と骨孔との早期固着を要し、整形外科分野において重要な課題である。本研究のSrSiPナノコーティング法により、人工靭帯のような耐熱性の低く、表面形状が複雑な材料の表面性状の改変が可能となり、人工靭帯周囲の骨誘導促進が期待できる。さらに本研究は前十字靭帯再建術のみならず、人工靭帯以外の医療材料への応用が可能であると考えられる。