2017 Fiscal Year Final Research Report
Regulation of liver repair via PGE receptor signaling
| Project/Area Number |
16K21350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
Digestive surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 肝修復 / プロスタグランジン |
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| Outline of Final Research Achievements |
Impaired liver repair after liver surgery causes liver dysfunction, which is associated with a increased risk of morbidity and mortality. Here, we show that membranous prostaglandin synthase suppresses liver repair after liver injury in mice. mPGES-1 promotes accumulation of inflammatory macrophages, but not reparative macrophages, leading to delay in liver repair. Mice treated with the mPGES-1 inhibitor displayed increased liver protection and repair.
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| Free Research Field |
外科学
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