Comparative genome analysis of functional endogenous viral elements using massive nucleotide sequence data

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21386
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Genome biology; Genetics/Chromosome dynamics
• Research Institution: Tokai University
• Principal Investigator: NAKAGAWA So 東海大学, 医学部, 助教 (70510014)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: レトロウイルス / レトロトランスポゾン / 比較ゲノム / 分子進化 / データベース / 機能ゲノム

Outline of Final Research Achievements

The aim of this research project is to clarify various new functions gained by endogenous viral elements (EVEs) in mammalian genomes and their genome evolution. I have developed an annotation database called gEVE for possible protein-coding sequences derived from EVEs. In this study, we have identified various new functional sequences derived from EVE using NGS data analyzed with this database. For example, we discovered a novel structural protein Gag-like retroviral gene expressed in bovine placenta by collaborative research. We also identified non-coding regions derived from EVE and predicted that it might have acquired the function such as promoters.

Free Research Field

ゲノム科学・バイオインフォマティクス・分子進化