2017 Fiscal Year Final Research Report
The wound healing system of nasal epithelial membrane and the effect of transplantation of nasal mucosal epithelial cell sheets
| Project/Area Number |
16K21391
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
Otorhinolaryngology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 創傷治癒 / 鼻副鼻腔 / 粘膜 / うさぎ / 線毛運動 / 上皮化 / 骨増生 / 粘膜シート |
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| Outline of Final Research Achievements |
In order to elucidate factors promoting wound healing of nasal mucosa in rabbits and to establish new treatment methods, rabbit mucosal wound modeling and rabbit nasal sinus bone disruption model were prepared. For both models, calcium alginate as an artificial material, membrane sheet transplantation using a temperature responsive culture dish. Rabbits were measured by CT for evaluation of the presence or absence of epithelialized grading, ciliated movement, and bone hyperplasia, using every 5 models. In addition to promoting epithelialization predominantly compared with the control group in each postoperative mucosal wound healing, it was suggested that the possibility of causing deterioration also depends on the condition. It is necessary to conduct a detailed examination further.
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| Free Research Field |
耳鼻咽喉科
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