Role of Cdc42 in the secretion of secretory IgA in salivary glands

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry; Integrative animal science
• Research Institution: Nihon University
• Principal Investigator: OKABAYASHI Ken 日本大学, 生物資源科学部, 講師 (20409072)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 唾液腺 / 分泌型IgA / Cdc42 / 自律神経

Outline of Final Research Achievements

To clarify the relationship of Cdc42 and transport of salivary component, the intracellular trafficking of IgA and paracellular transport were investigated using SMIE cells transfected with Cdc42. It was suggested that Cdc42 enhanced paracellular transport, though we could not find out the contribution of Cdc42 to intracellular trafficking. In addition, the regulation of IgA secretion by autonomic nervous system was investigated using submandibular gland cells. In submandibular gland, IgA secretion was suggested to be regulated via beta receptor. We clarified partially that the role of Cdc42 in paracellular transport, and the regulation of IgA secretion with autonomic nervous system in submandibular gland.

Free Research Field

農学