Maturation abnormalities of astrocytes in the brain of mouse model of psychiatric disorders

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21457
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology; Neurophysiology / General neuroscience
• Research Institution: Fujita Health University
• Principal Investigator: Hagihara Hideo 藤田保健衛生大学, 総合医科学研究所, 講師 (80514504)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: アストロサイト

Outline of Final Research Achievements

Schnurri-2 knockout mice, an animal model of schizophrenia, have been shown to exhibit maturation abnormalities in the granule cells of the hippocampal dentate gyrus (DG), in which the molecular and physiological properties are similar to those of normal immature granule cells (Takao et al, Neuropsychopharmacology, 2013). Recently, maturation abnormalities of the astrocytes have also been suggested in the brain of the mutant mice. In this study, we performed bioinformatics analyses of transcriptome data sets to get insights into potential maturation abnormalities of the cell types in the brain of Schnurri-2 knockout mice.

Free Research Field

神経科学