Custom-made design of inhaled dry powder could realize personalized medicine of respiratory disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21500
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Properties in chemical engineering process/Transfer operation/Unit operation; Physical pharmacy
• Research Institution: Osaka University of Pharmaceutical Sciences
• Principal Investigator: Kadota Kazunori 大阪薬科大学, 薬学部, 講師(移行) (50709516)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 吸入粉末製剤 / 数値シミュレーション / 噴霧乾燥法 / 中空粒子

Outline of Final Research Achievements

A synergistic study on computational fluid dynamics (CFD) simulation and sample preparation with highly branched cyclic dextrin (HBCD) as an excipient matrix for dry powder inhaler formulations were performed. Fine particles with HBCD were prepared by spray-drying. Regarding inhalational properties, HBCD formulations had higher emitted dose and fine-particle fractions than formulations of all other sugars tested. Our results confirm the feasibility of the formulation of hydrophilic and hydrophobic drug substances into a single-dosage preparation for pulmonary delivery using HBCD as an excipient. CFD analysis revealed that high inhalation performance was related to the true density and particle size of SDPs. The results on CFD simulations made a prediction about the particle behavior or deposition in pulmonary airways.

Free Research Field

製剤学、粉体工学