2017 Fiscal Year Final Research Report
Analysis of phospholipid metabolism for thymus function
| Project/Area Number |
16K21651
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
Embryonic/Neonatal medicine
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
YOSHIDA TOMOMI 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (30610216)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | リン脂質 / 胸腺 |
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| Outline of Final Research Achievements |
Thymus specific LPCAT3 deleted mouse were generated using lck-Cre and CD4-Cre mouse. T-cell population were not different between LPCAT3 wild-type mice and LPCAT3 deleted mice in CD4-Cre mouse by flow cytometry. However, a cell number of thymocyte was slightly decreased in LPCAT3 deleted mice having lck-Cre. The populations of DP cells, CD4SP cells and CD8SP cells were decreased, and DN cells were increased in LPCAT3 deleted mice. Now, the precise mechanism is searched.
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| Free Research Field |
脂質生物化学
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