Integrative analysis of metagenomics and metabolomics for eosinophilic gastrointestinal disorders in children

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21670
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics; Collagenous pathology/Allergology
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Shoda Tetsuo 国立研究開発法人国立成育医療研究センター, 生体防御系内科部, 医師研究員 (00724311)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 好酸球性消化管疾患 / 腸内細菌叢 / メタボローム

Outline of Final Research Achievements

Microbes may increase susceptibility to eosinophilic gastrointestinal disorders (EGID) by producing bioactive metabolites that affect immune activity and epithelial function. To uncover disease-associated microbial and metabolomics profile in pediatric EGID by next-generation sequencing analysis, a case-control study (EGID vs control, n=5 vs 10) was conducted. Several analyses, including principal coordinate analysis, cluster analysis and integrated analysis of both microbiome and metabolome, did not show significant differences between EGID and control. In this case-control study, a disease-associated microbial and metabolomics profile in pediatric EGID was not found.

Free Research Field

小児科