Positive Psychological Factor, Social Capital and its association with Healthy Aging(Fostering Joint International Research)

2022 Fiscal Year Annual Research Report

• Project/Area Number: 16KK0059
• Research Institution: Osaka University
• Principal Investigator: 白井 こころ 大阪大学, 大学院医学系研究科, 特任准教授(常勤) (80530211)
• Project Period (FY): 2017 – 2022
• Keywords: 健康の社会的決定要因 / 健康長寿 / 生活習慣病予防

Outline of Annual Research Achievements

本研究では、健康の社会的決定要因（Social Determinants of Health）の視点から、高齢者の健康長寿の社会・心理的な関連要因について、生活習慣と併せて、社会経済的背景やポジティブ・ネガティブな心理的特性、ならびに人と人とのつながりやサポートを含む社会関係に着目して、その影響の検討を目的とした。本研究の遂行にあたり、大規模コホート研究データを用いて、健康の社会心理的な決定要因の縦断的検討を行うとともに、日本国内で収集したデータを用いて、生体的・社会構造的なメカニズムの検討を進めた。また、日本国内の研究データ(JACC, JPHC, JAGES研究データ等)を使用すると共に、米国・英国・北欧の共同研究者とともに、海外のコホートデータを用いた比較共同研究を進めた。英国のELSA研究、フィンランドの職域コホートデータ等を用いて、データのHarmonizationと共同分析を行い研究報告を進めた。本研究の進展により、就労状況、収入などの社会経済的背景、また運動、栄養などの生活習慣、趣味や社会参加活動、生きがいの有無、笑いの頻度などの心理的要因について、日本・英国・北欧で、総死亡や循環器疾患死亡、認知症発症、うつなどの健康指標との関係性が同様の傾向であることが示された。一方で、教育歴、婚姻、楽観性志向、幸福度などの影響は、性別や被災状況、社会経済的状況などで影響が異なる傾向が確認された。各国に共通する関係性についても、性別、社会的要因、疾病既往等の条件によって、影響が異なる結果が示唆されており、生活習慣病や認知症などの健康長寿の質・量に直結する疾病について、リスク要因の検討と共に、修飾要因や保護的要因の検討が重要であることが示唆された。本研究は、世界的な新型コロナ感染症拡大の影響により、180日間の海外渡航日数を満たせなかったが、計画を修正して研究を完了した。

Research Products

• [Int'l Joint Research] ハーバード大学公衆衛生大学院(米国) (2018)
  • Year and Date: 2018-10-09 – 2018-10-13 | 2018-12-142018-12-20 | 2019-11-082019-11-20
  • Country Name: U.S.A.
  • Counterpart Institution: ハーバード大学公衆衛生大学院
  • Co-investigator Overseas: Ichiro Kawachi
  • Department: Society and Behavioral Science
  • Job Title: Professor
• [Int'l Joint Research] University of London (King’s college London & UCL）(英国) (2018)
  • Year and Date: 2018-06-11 – 2018-06-17 | 2018-06-272018-07-31 | 2018-08-082018-10-13 | 2019-06-122019-06-19 | 2019-10-302019-11-07
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: University of London (King’s college London & UCL）
  • Co-investigator Overseas: Andrew Steptoe & Karen Graizar
  • Department: Behavioural Science and Health
  • Job Title: Professors
• [Journal Article] Association of Blood Urea Nitrogen with Cardiovascular Diseases and All-Cause Mortality in USA Adults: Results from NHANES 1999-2006 (2023)
  • Author(s): Hong C, Zhu H, Zhou X, Zhai X, Li S, Ma W, Liu K, Shirai K, Sheerah HA, Cao J.
  • Journal Title: Nutrients Volume: 15(2) Pages: 461
  • DOI: 10.3390/nu15020461
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Daytime napping and risk of liver cancer: A large population-based prospective cohort study (2023)
  • Author(s): Arafa A, Eshak ES, Shirai K, Muraki I, Tamakoshi A, Iso H; JACC Study Group.
  • Journal Title: Ann Hepatol Volume: 28(2) Pages: 100877
  • DOI: 10.1016/j.aohep.2022.100877
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sex- and age-specific impacts of smoking, overweight/obesity, hypertension, and diabetes mellitus in the development of disabling dementia in a Japanese population (2023)
  • Author(s): Tanaka M, Imano H, Hayama-Terada M, Muraki I, Shirai K, Yamagishi K, Okada T, Kiyama M, Kitamura A, Takayama Y, Iso H.
  • Journal Title: Environ Health Prev Med Volume: 28 Pages: 11
  • DOI: 10.1265/ehpm.22-00187
  • Peer Reviewed
• [Journal Article] Frequency of going outdoors and risk of poor oral health among older Japanese adults: a longitudinal cohort from the Japan Gerontological Evaluation Study (2023)
  • Author(s): Ishimura K, Sakaniwa R, Shirai K, Aida J, Takeuchi K, Kondo K, Iso H.
  • Journal Title: J Epidemiol Volume: - Pages: -
  • DOI: 10.2188/jea.JE20220221
  • Peer Reviewed
• [Journal Article] Hobby engagement and risk of disabling dementia (2022)
  • Author(s): Matsumura T, Muraki I, Ikeda A, Yamagishi K, Shirai K, Yasuda N, Sawada N, Inoue M, Iso H, Brunner EJ, Tsugane S.
  • Journal Title: J Epidemiol Volume: - Pages: -
  • DOI: 10.2188/jea.JE20210489
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mind-body therapies for older adults with dementia: a systematic review and meta-analysis (2022)
  • Author(s): Wang Y, Tang C, Fan X, Shirai K, Dong JY.
  • Journal Title: Eur Geriatr Med Volume: 13(4) Pages: 881-891
  • DOI: 10.1007/s41999-022-00639-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ikigai and subsequent health and wellbeing among Japanese older adults: Longitudinal outcome-wide analysis (2022)
  • Author(s): Okuzono SS, Shiba K, Kim ES, Shirai K, Kondo N, Fujiwara T, Kondo K, Lomas T, Trudel-Fitzgerald C, Kawachi I, VanderWeele TJ.
  • Journal Title: Lancet Reg Health West Pac Volume: 21 Pages: 100391
  • DOI: 10.1016/j.lanwpc.2022.100391
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optimism and Longevity Among Japanese Older Adults (2022)
  • Author(s): Okuzono SS, Shiba K, Lee HH, Shirai K, Koga HK, Kondo N, Fujiwara T, Kondo K, Grodstein F, Kubzansky LD, Trudel-Fitzgerald C.
  • Journal Title: J Happiness Stud Volume: 23(6) Pages: 2581-2595
  • DOI: 10.1007/s10902-022-00511-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Smoking cessation, weight gain and risk of cardiovascular disease (2022)
  • Author(s): Wang X, Dong JY, Cui R, Muraki I, Shirai K, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Sawada N, Iso H, Tsugane S; Japan Public Health Center-based Prospective Study Group.
  • Journal Title: Heart Volume: 108(5) Pages: 375-381
  • DOI: 10.1136/heartjnl-2021-318972
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Breakfast Type and Cardiovascular Mortality: The Japan Collaborative Cohort Study (2022)
  • Author(s): Tang J, Dong JY, Eshak ES, Cui R, Shirai K, Liu K, Tamakoshi A, Iso H; JACC study group.
  • Journal Title: J Atheroscler Thromb Volume: - Pages: -
  • DOI: 10.5551/jat.63564
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of Nutrition Education on the Vegetable Intake of Residents in Okinawa (2022)
  • Author(s): Aniya F, Sakima A, Takakura M, Shirai K, Shimabukuro M, Todoriki H, Okumura K, Takemura K, Kinjyo N, Ohya Y.
  • Journal Title: Circ Rep Volume: 4(3) Pages: 131-144
  • DOI: 10.1253/circrep.CR-21-0152
  • Peer Reviewed
• [Journal Article] Evaluation of Complexity Measurement Tools for Correlations with Health-Related Outcomes, Health Care Costs and Impacts on Healthcare Providers: A Scoping Review (2022)
  • Author(s): Kaneko H, Hanamoto A, Yamamoto-Kataoka S, Kataoka Y, Aoki T, Shirai K, Iso H.
  • Journal Title: Int J Environ Res Public Health Volume: 19(23) Pages: 16113
  • DOI: 10.3390/ijerph192316113
  • Peer Reviewed
• [Journal Article] Positive psychological factors and the risk of pneumonia-associated mortality: Japan Collaborative Cohort Study (2022)
  • Author(s): Sumiyama A, Shirai K, Imano H, Eguchi E, Muraki I, Tamakoshi A, Iso H; for JACC Study Group.
  • Journal Title: J Psychosom Res Volume: 160 Pages: 110971
  • DOI: 10.1016/j.jpsychores.2022.110971
  • Peer Reviewed
• [Journal Article] The Association Between Living Area in Childhood and Respiratory Disease Mortality in Adulthood (2022)
  • Author(s): Iwasaki A, Teramoto M, Muraki I, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: Int J Public Health Volume: 67 Pages: 1604778
  • DOI: 10.3389/ijph.2022.1604778
  • Peer Reviewed
• [Journal Article] Pneumonia and subsequent risk of dementia: Evidence from the Japan Gerontological evaluation study (2022)
  • Author(s): Khairan P, Shirai K, Shobugawa Y, Cadar D, Saito T, Kondo K, Sobue T, Iso H.
  • Journal Title: Int J Geriatr Psychiatry Volume: 37(11) Pages: -
  • DOI: 10.1002/gps.5825
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Occasions for laughter and dementia risk: Findings from a six-year cohort study (2022)
  • Author(s): Wang Y, Shirai K, Ohira T, Hirosaki M, Kondo N, Takeuchi K, Yamaguchi C, Tamada Y, Kondo K, Cadar D, Iso H.
  • Journal Title: Geriatr Gerontol Int Volume: 22(5) Pages: 392-398
  • DOI: 10.1111/ggi.14371
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Soy Intake and Risk of Type 2 Diabetes Among Japanese Men and Women: JACC Study (2022)
  • Author(s): Yan F, Eshak ES, Shirai K, Dong JY, Muraki I, Tamakoshi A, Iso H.
  • Journal Title: Front Nutr Volume: 8 Pages: 813742
  • DOI: 10.3389/fnut.2021.813742
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The association between midlife living arrangement and psychiatrist-diagnosed depression in later life: who among your family members reduces the risk of depression? (2022)
  • Author(s): Ogawa K, Shirai K, Nozaki S, Shikimoto R, Sawada N, Mimura M, Iso H, Tsugane S; Japan Public Health Center-based Prospective Study Group.
  • Journal Title: Transl Psychiatry Volume: 12(1) Pages: 156
  • DOI: 10.1038/s41398-022-01880-7
  • Peer Reviewed
• [Journal Article] Effects of a laughter program on body weight and mental health among Japanese people with metabolic syndrome risk factors: a randomized controlled trial (2022)
  • Author(s): Funakubo N, Eguchi E, Hayashi R, Hirosaki M, Shirai K, Okazaki K, Nakano H, Hayashi F, Omata J, Imano H, Iso H, Ohira T.
  • Journal Title: BMC Geriatr Volume: 22(1) Pages: 361
  • DOI: 10.1186/s12877-022-03038-y
  • Peer Reviewed
• [Journal Article] Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age (2022)
  • Author(s): Sakaniwa R, Noguchi M, Imano H, Shirai K, Tamakoshi A, Iso H; JACC Study Group.
  • Journal Title: Age Ageing Volume: 51(5) Pages: afac080
  • DOI: 10.1093/ageing/afac080
  • Peer Reviewed
• [Journal Article] Dairy Intake and the Risk of Esophageal Cancer: The JACC Study (2022)
  • Author(s): Arafa A, Eshak ES, Shirai K, Muraki I, Tamakoshi A, Iso H.
  • Journal Title: J Epidemiol Volume: 32(6) Pages: 298-300
  • DOI: 10.2188/jea.JE20220037
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Purpose in life (Ikigai) and employment status in relation to cardiovascular mortality: the Japan Collaborative Cohort Study (2022)
  • Author(s): Miyazaki J, Shirai K, Kimura T, Ikehara S, Tamakoshi A, Iso H.
  • Journal Title: BMJ Open Volume: 12(10) Pages: e059725
  • DOI: 10.1136/bmjopen-2021-059725
  • Peer Reviewed
• [Journal Article] Leisure activities and instrumental activities of daily living: A 3-year cohort study from the Japan Gerontological Evaluation Study (2022)
  • Author(s): Ukawa S, Tamakoshi A, Tani Y, Sasaki Y, Saito J, Haseda M, Shirai K, Kondo N, Kondo K, Kawachi I.
  • Journal Title: Geriatr Gerontol Int Volume: 22(2) Pages: 152-159
  • DOI: 10.1111/ggi.14334
  • Peer Reviewed
• [Journal Article] Early-Adulthood Weight Change and Later Physical Activity in Relation to Cardiovascular and All-Cause Mortality: NHANES 1999-2014 (2022)
  • Author(s): Xiao X, Tang C, Zhai X, Li S, Ma W, Liu K, Kokoro S, Sheerah HA, Zhu H, Cao J.
  • Journal Title: Nutrients Volume: 14(23) Pages: 4974
  • DOI: 10.3390/nu14234974
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Perspectives of Healthcare Providers towards Remote Medical Interpreting Services in Japan (2022)
  • Author(s): Saeki S, Minamitani K, Iwaoka F, Shirai K.
  • Journal Title: Healthcare Volume: 11(1) Pages: 112
  • DOI: 10.3390/healthcare11010112
  • Peer Reviewed
• [Journal Article] The number of leisure-time activities and risk of functional disability among Japanese older population: the JAGES cohort (2022)
  • Author(s): Fuji Y, Sakaniwa R, Shirai K, Saito T, Ukawa S, Iso H, Kondo K.
  • Journal Title: Prev Med Rep Volume: 26 Pages: 101741
  • DOI: 10.1016/j.pmedr.2022.101741
  • Peer Reviewed
• [Journal Article] Associations of dietary intakes of vitamins B(1) and B(3) with risk of mortality from CVD among Japanese men and women: the Japan Collaborative Cohort study (2022)
  • Author(s): Tang C, Eshak ES, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: Br J Nutr Volume: 129(7) Pages: 1‐8
  • DOI: 10.1017/S0007114522001209
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between outdoor artificial light at night and sleep duration among older adults in China: A cross-sectional study (2022)
  • Author(s): Hu K, Li W, Zhang Y, Chen H, Bai C, Yang Z, Lorenz T, Liu K, Shirai K, Song J, Zhao Q, Zhao Y, Zhang JJ, Wei J, Pan J, Qi J, Ye T, Zeng Y, Yao Y.
  • Journal Title: Environ Res Volume: 212(Pt B) Pages: 113343
  • DOI: 10.1016/j.envres.2022.113343
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between Dietary Manganese Intake and Mortality from Cardiovascular Disease in Japanese Population: The Japan Collaborative Cohort Study (2022)
  • Author(s): Meishuo O, Eshak ES, Muraki I, Cui R, Shirai K, Iso H, Tamakoshi A.
  • Journal Title: J Atheroscler Thromb Volume: 29(10) Pages: 1432-1447
  • DOI: 10.5551/jat.63195
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Secondhand Smoke Exposure in Childhood and Mortality from Coronary Heart Disease in Adulthood: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (2022)
  • Author(s): Teramoto M, Iso H, Muraki I, Shirai K, Tamakoshi A.
  • Journal Title: J Atheroscler Thromb Volume: - Pages: -
  • DOI: 10.5551/jat.63857
  • Peer Reviewed
• [Journal Article] Dairy intake and the risk of pancreatic cancer: the Japan Collaborative Cohort Study (JACC Study) and meta-analysis of prospective cohort studies (2022)
  • Author(s): Arafa A, Eshak ES, Dong JY, Shirai K, Muraki I, Iso H, Tamakoshi A; JACC Study Group.
  • Journal Title: Br J Nutr Volume: 128(6) Pages: 1147-1155
  • DOI: 10.1017/S0007114521004232
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Does laughing with others lower the risk of functional disability among older Japanese adults? The JAGES prospective cohort study (2022)
  • Author(s): Tamada Y, Yamaguchi C, Saito M, Ohira T, Shirai K, Kondo K, Takeuchi K.
  • Journal Title: Prev Med Volume: 155 Pages: 106945
  • DOI: 10.1016/j.ypmed.2021.106945
  • Peer Reviewed
• [Journal Article] Smoking Cessation and Mortality from Aortic Dissection and Aneurysm: Findings from the Japan Collaborative Cohort (JACC) Study (2022)
  • Author(s): Yang Y, Yamagishi K, Kihara T, Cui R, Eshak ES, Muraki I, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: J Atheroscler Thromb Volume: 30(4) Pages: 348-363
  • DOI: 10.5551/jat.63258
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Body Mass Index and Mortality from Nonrheumatic Aortic Valve Disease among Japanese Men and Women (2022)
  • Author(s): Teramoto M, Yamagishi K, Cui R, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: J Atheroscler Thromb Volume: 30(2) Pages: 150-159
  • DOI: 10.5551/jat.63452
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Modifying Effect of Outdoor Recreational Activity on the Association Between Anger Expression and Cardiovascular Disease Risk: The Circulatory Risk in Communities Study (2022)
  • Author(s): Tezuka K, Kubota Y, Ohira T, Muraki I, Hayama-Terada M, Shimizu Y, Imano H, Shirai K, Okada T, Kiyama M, Iso H.
  • Journal Title: Psychosom Med Volume: 85(2) Pages: 182-187
  • DOI: 10.1097/PSY.0000000000001166
  • Peer Reviewed
• [Presentation] 高血圧有病者における夕食時間と循環器疾患死亡との関連：JACC study (2022)
  • Author(s): 乾 智貴、橘田 真理、中村 友哉、坂庭 嶺人、白井 こころ、今野 弘規、石原 真穂、Ehab E Shak、董 加穀、玉腰 暁子、磯 博康
  • Organizer: 第32回 日本疫学会学術総会
• [Presentation] 小児期の居住地域特性と将来の循環器疾患死亡との関連：JACC Study (2022)
  • Author(s): 増田 奈保子、石田 菜津美、KIM HWANGBEUM、坂庭 嶺人、白井 こころ、今野 弘規、石原 真穂、Ehab E Shak、董 加穀、玉腰 暁子、磯 博康
  • Organizer: 第32回 日本疫学会学術総会
• [Presentation] 高齢者の日常生活における笑いとフレイル発生リスクとの関連：JAGES縦断研究 (2022)
  • Author(s): 玉田 雄大、竹内 研時、斉藤 雅茂、山口 知香枝、白井 こころ、大平 哲也、小嶋 雅代、若井 建志、近藤 克則
  • Organizer: 第32回 日本疫学会学術総会
• [Presentation] 生きがいおよび生活習慣の組み合わせと循環器疾患死亡との関連：JACCスタディ (2022)
  • Author(s): 見目 能基、江口 依里、吉田 知克、鶴田 浩惇、白井 こころ、玉腰 暁子、磯 博康、大平 哲也
  • Organizer: 第32回 日本疫学会学術総会
• [Presentation] 人に頼られている感覚および生活習慣の組み合わせと循環器疾患死亡との関連： JACCスタディ (2022)
  • Author(s): 鶴田 浩惇、江口 依里、吉田 知克、見目 能基、白井 こころ、玉腰 暁子、磯 博康、大平 哲也
  • Organizer: 第32回 日本疫学会学術総会
• [Presentation] Association between ikigai and hypertension in Japanese population: a cross-sectional study (2022)
  • Author(s): 張 競文、白井こころ、今野 弘規、田中 麻理、李 嘉琦、川内 はるな、王 雨、岡本 華奈、近藤 克則、北村 明彦、磯 博康
  • Organizer: 第32回 日本疫学会学術総会
• [Presentation] 高齢者における通いの場参加と健康・well-being 34指標の変化：JAGES 2013-2016-2019アウトカムワイド分析 (2022)
  • Author(s): 井手 一茂、中込 敦士、辻 大士、山本 貴文、渡邉 良太、芝 孝一郎、横山 芽衣子、白井こころ、近藤克則
  • Organizer: 第32回 日本疫学会学術総会
• [Presentation] Well-being・幸福と健康：疫学・予防医学研究への示唆 (2022)
  • Author(s): 白井こころ
  • Organizer: 第32回日本疫学会学術総会
  • Invited
• [Presentation] 飲酒習慣と腸内細菌叢との関連：CIRCS研究 (2022)
  • Author(s): 長尾 匡則、細見 晃司 、朴 鐘旭 、白井 こころ 、舟久保 徳美 、高田 碧 、山岸 良匡 、清水 悠路 、村木 功 、今野 弘 規 、岡田 武夫 、木山 昌彦 、村上 晴香 、南里 妃名子 、水 口 賢司 、宮地 元彦 、國澤 純 、磯 博康、大平 哲也
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 共分散構造分析モデリングによるフレイルの関連因子の検討 (2022)
  • Author(s): 孫 智超、白井 こころ、北村 明彦 、平井 啓 、羽山 実奈 、高山 佳洋 、近藤 克則
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 中年期と高齢前期における死亡リスクの検討 (2022)
  • Author(s): 松村 拓実、北村 明彦、羽山 実奈、高山 佳洋、田中 麻 理、村木 功、白井 こころ、今野 弘規、高田 碧、清 水 悠路、岡田 武夫、木山 昌彦、磯 博康
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] ストレス対処能力（SOC）と要介護認知症発症 との関連：JAGESプロジェクト (2022)
  • Author(s): 李嘉琦、白井こころ、磯博康、近藤克則
  • Organizer: 第81回公衆衛生学会総会
• [Presentation] 中年期・前期高齢者の朝食欠食と将来の要介護認 知症発症との関連 (2022)
  • Author(s): 田中麻理、今野弘規、羽山実奈、村木功、白井こころ、山岸良匡、岡田武夫、木山昌彦、北村明彦、髙山佳洋、磯博康
  • Organizer: 第81回公衆衛生学会総会
• [Presentation] シンポジウム：社会関係とWELL-BEING（幸福・健康） (2022)
  • Author(s): 澤田康幸、内田 由紀子、小林 正弥、白井 こころ、原田 謙、近藤 克則
  • Organizer: 第3回日本社会関係学会総会
  • Invited
• [Presentation] 中年期の同居家族と老年期における精神科医に診断されたうつ病との関連性：多目的コホート研究佐久こころの検診研究 (2022)
  • Author(s): 小川 憲人、今野 弘規、白井 こころ、澤田 典絵、磯 博康
  • Organizer: 第81回公衆衛生学会総会