Regulation of obesity and NASH/HCC via glutamine metabolism and its clinical approach(Fostering Joint International Research)

2017 Fiscal Year Final Research Report

• Project/Area Number: 16KK0197
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Chiba University
• Principal Investigator: Suzuki Sawako 千葉大学, 医学部附属病院, 助教 (60400892)
• Research Collaborator: Prives Carol Clumbia University, Biological Science研究室, 教授 ; Venkatesh Divya Clumbia University, Biological Science研究室, Postdoctoral Research Scientist
• Project Period (FY): 2016 – 2017
• Keywords: グルタミン代謝 / 生活習慣病 / 肝癌 / 統合解析 / 細胞死

Outline of Final Research Achievements

We have revealed that GLS2 mediated glutamine metabolism and related to lifestyle diseases and hepatocellular tumorigenesis. In this study, we identified key molecules of GLS2 associated with gluconeogenesis, lipid metabolism, insulin secretion and insulin resistance using the combination of metabolome analysis and RNA sequence analysis. Furthermore, we found GLS2, but not GLS1, showed tumor suppressor function through new cell death different from apoptosis and necrosis by reviewing our research from a global point of view. These results might important to explain the paradox action against tumorigenesis of GLS1 and GLS2.

Free Research Field

糖尿病代謝内分泌内科、エネルギー代謝研究、癌抑制遺伝子