Evaluation of longitudinal change in early glaucoma using big data(Fostering Joint International Research)

2018 Fiscal Year Annual Research Report

• Project/Area Number: 16KK0208
• Research Institution: Saitama Medical University
• Principal Investigator: 庄司 拓平 埼玉医科大学, 医学部, 講師 (70637058)
• Project Period (FY): 2016 – 2018
• Keywords: 緑内障 / 光干渉断層計 / 光干渉断層血管撮影 / 縦断解析

Outline of Annual Research Achievements

カリフォルニア大学サンディエゴ校において、20年以上蓄積された眼底写真、視野検査結果、眼圧値、角膜厚、光干渉断層計(OCT)データを縦断解析し、緑内障進行と関連する因子分析を行った。
さらには、2015年から蓄積され始めた光干渉断層血管撮影(OCTA)データを用いて、緑内障の発症と構造変化、血管動態変化と機能変化について横断的解析および縦断的解析を行った。
研究実績としては、緑内障の進行とともに、放射状乳頭周囲毛細血管（RPC)の血管密度が低下するだけでなく、網膜神経節細胞の血管動態に関与する黄斑部血管密度もまた低下することを報告した。そして、この黄斑部の血管密度は視機能である視野検査感度と有意に相関することも報告した。さらには、進行した緑内障では経時的に変化することも判明し、構造変化とは異なる進行過程を示唆することを示した。
光干渉断層計を用いた経時的観察では、糖尿病を合併した緑内障眼においては、糖尿病を持たない年齢マッチさせた集団と比べ、進行が緩徐であることも示した。糖尿病自体または糖尿病治療薬が緑内障進行と関連している可能性を示すこともできた。

Research Products

• [Int'l Joint Research] カリフォルニア大学サンディエゴ校(米国) (2017)
  • Year and Date: 2017-02-01 – 2017-08-21 | 2017-11-092017-11-13 | 2018-03-082018-03-20 | 2018-10-252018-11-05
  • Country Name: U.S.A.
  • Counterpart Institution: カリフォルニア大学サンディエゴ校
  • Co-investigator Overseas: Robert N Weinreb
  • Department: Department of Ophthalmology
  • Job Title: Professor
• [Journal Article] Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma (2019)
  • Author(s): Hou Huiyuan、Moghimi Sasan、Zangwill Linda M.、Shoji Takuhei、Ghahari Elham、Penteado Rafaella C.、Akagi Tadamichi、Manalastas Patricia Isabel C.、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 199 Pages: 120～132
  • DOI: 10.1016/j.ajo.2018.11.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of Macular and Circumpapillary Microvasculature with Visual Field Sensitivity in Advanced Glaucoma (2019)
  • Author(s): Ghahari Elham、Bowd Christopher、Zangwill Linda M.、Proudfoot James、Hasenstab Kyle A.、Hou Huiyuan、Penteado Rafaella C.、Manalastas Patricia Isabel C.、Moghimi Sasan、Shoji Takuhei、Christopher Mark、Yarmohammadi Adeleh、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1016/j.ajo.2019.03.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Association Between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect, and Healthy Eyes (2018)
  • Author(s): Manalastas Patricia I. C.、Zangwill Linda M.、Daga Fabio B.、Christopher Mark A.、Saunders Luke J.、Shoji Takuhei、Akagi Tadamichi、Penteado Rafaella C.、Yarmohammadi Adeleh、Suh Min H.、Medeiros Felipe A.、Weinreb Robert N.
  • Journal Title: Journal of Glaucoma Volume: 27 Pages: 227～232
  • DOI: 10.1097/IJG.0000000000000862
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients (2018)
  • Author(s): Hou Huiyuan、Shoji Takuhei、Zangwill Linda M.、Moghimi Sasan、Saunders Luke J.、Hasenstab Kyle、Ghahari Elham、Manalastas Patricia Isabel C.、Akagi Tadamichi、Christopher Mark、Penteado Rafaella C.、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 189 Pages: 1～9
  • DOI: 10.1016/j.ajo.2018.02.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Macular Vessel Density in Glaucomatous Eyes With Focal Lamina Cribrosa Defects (2018)
  • Author(s): Ghahari Elham、Bowd Christopher、Zangwill Linda M.、Suh Min Hee、Shoji Takuhei、Hasenstab Kyle A.、Saunders Luke J.、Moghimi Sasan、Hou Huiyuan、Manalastas Patricia I.C.、Penteado Rafaella C.、Weinreb Robert N.
  • Journal Title: Journal of Glaucoma Volume: 27 Pages: 342～349
  • DOI: 10.1097/IJG.0000000000000922
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes (2018)
  • Author(s): Hou Huiyuan、Moghimi Sasan、Zangwill Linda M.、Shoji Takuhei、Ghahari Elham、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 190 Pages: 69～77
  • DOI: 10.1016/j.ajo.2018.03.026
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optical Coherence Tomography Angiography Macular Vascular Density Measurements and the Central 10-2 Visual Field in Glaucoma (2018)
  • Author(s): Penteado Rafaella C.、Zangwill Linda M.、Daga F?bio B.、Saunders Luke J.、Manalastas Patricia Isabel C.、Shoji Takuhei、Akagi Tadamichi、Christopher Mark、Yarmohammadi Adeleh、Moghimi Sasan、Weinreb Robert N.
  • Journal Title: Journal of Glaucoma Volume: 1 Pages: 1～1
  • DOI: 10.1097/IJG.0000000000000964
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Macular and Optic Nerve Head Vessel Density and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma (2018)
  • Author(s): Moghimi Sasan、Zangwill Linda M.、Penteado Rafaella C.、Hasenstab Kyle、Ghahari Elham、Hou Huiyuan、Christopher Mark、Yarmohammadi Adeleh、Manalastas Patricia Isabel C.、Shoji Takuhei、Bowd Christopher、Weinreb Robert N.
  • Journal Title: Ophthalmology Volume: 125 Pages: 1720～1728
  • DOI: 10.1016/j.ophtha.2018.05.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography (2018)
  • Author(s): Akagi Tadamichi、Zangwill Linda M.、Shoji Takuhei、Suh Min Hee、Saunders Luke J.、Yarmohammadi Adeleh、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
  • Journal Title: PLOS ONE Volume: 13 Pages: e0201729
  • DOI: 10.1371/journal.pone.0201729
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between Rates of Retinal Nerve Fiber Layer Thinning and Previous Disc Hemorrhage in Glaucoma (2018)
  • Author(s): Akagi Tadamichi、Saunders Luke J.、Shoji Takuhei、De Moraes Carlos Gustavo、Skaat Alon、Manalastas Patricia Isabel C.、Girkin Christopher A.、Liebmann Jeffrey M.、Zangwill Linda M.、Weinreb Robert N.
  • Journal Title: Ophthalmology Glaucoma Volume: 1 Pages: 23～31
  • DOI: 10.1016/j.ogla.2018.06.001
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Comparison of structural and vessel density measurements in eyes with parafoveal scotoma and peripheral nasal step glaucoma (2018)
  • Author(s): Takuhei Shoji, Linda M. Zangwill, Tadamichi Akagi,, Luke J. Saunders, Adeleh Yarmohammadi, Patricia Isabel C. Manalastas, Rafaella Cleto Penteado, Huiyuan Hou, Elham Ghahari, Robert N. Weinreb
  • Organizer: American Academy of Ophthalmology (AAO) 2017 Annual Meeting,
  • Int'l Joint Research
• [Presentation] The African Descent and Glaucouma Evaluation Study : Racial Difference in the Rate of Retinal Nerve Fiber Layer Thinning in Eyes Suspected of Glaucouma : 5-Year Follow-Up (2018)
  • Author(s): Takuhei Shoji ,Tadamishi AKAGI, Luke J.SAUNDERS, Robert N.WEINREB, Linda M.ZANGWILL
  • Organizer: 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
  • Int'l Joint Research
• [Presentation] Macular and peripapillary vascular dropout are associated with disease severity in advanced glaucoma (2018)
  • Author(s): Ghahari, Elham; Zangwill, Linda M; Bowd, C; Hasenstab, Kyle A; Hou, Huiyuan; Penteado, Rafaella C; Manalastas, Patricia Isabel C; Moghimi, S; Shoji, Takuhei; Li, Andrew, J; Nguyen, Khoa; Villatoro, George; Yarmohammadi, Adeleh; Weinreb, Robert N.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] COMPARISON OF SUPERFICIAL VERSUS DEEP MACULA VESSEL DENSITY MEASUREMENTS IN NORMAL, GLAUCOMA SUSPECT, AND GLAUCOMA EYES (2018)
  • Author(s): Manalastas, Patricia Isabel C. Moghimi, Sasan; Zangwill, Linda M.; Christopher, Mark A.; Hasenstab, Kyle A.; Penteado, Rafaella C. Hou, HuiYuan. Shoji, Takuhei. Ghahari, Elham. Li, Andrew, J. Nguyen, Khoa. Villatoro, George. Yarmohammadi, Adeleh. Weinreb, Robert N.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Progression of primary open angle glaucoma in diabetic and non-diabetic patients (2018)
  • Author(s): Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders L, Hasenstab K, Ghahari E, Manalatas PIC, Akagi T, Christopher M, Penteado R, Weinreb RN
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Cross-sectional association between OCT angiography-measured optic nerve head and macular vessel densities and age in healthy eyes (2018)
  • Author(s): Nguyen K, Manalastas PI, Bowd C, Hasenstab K, Li A, Penteado R, Hou H, Shoji T, Villatoro G, Ghahari E, Moghimi S, Weinreb RN, Zangwill LM
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
  • Int'l Joint Research