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2007 Fiscal Year Final Research Report Summary

Postnatal developmental changes in synaptic molecules underlying maturation of excitatory synaptic transmission and synaptic regulation

Research Project

Project/Area Number 17002013
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionDoshisha University (2007)
The University of Tokyo (2005-2006)

Principal Investigator

TAKAHASHI Tomoyuki  Doshisha University, Faculty of Life and Medical Sciences, Professor (40092415)

Co-Investigator(Kenkyū-buntansha) TUJIMOTO Tetsuhiro  University of Tokyo, Graduate School of Medicine, Lecturer (40212055)
Project Period (FY) 2005 – 2007
KeywordsPotassium channcl / Ca^<2+>channel inactivation / Calyx of Held / Postnatal development / Transmitter release / Calmodulin / AMPA receptors / Residual Ca^<2+>
Research Abstract

(1) During the postnatal development Kv3 and Kv1 currents underwent a parallel increase, and became faster. Specific block of these channels indicated that the developmental changes of Kv3 and Kv1 contribute to establishment of reliable firing at high frequency, and stabilizing the nerve terminal, respectively (Nakamura & Takahashi, 2007)
(2) Bath-applied 4-CmC markedly increased the EPSC amplitude at the calyx of Held by inhibiting presynaptic voltage-gated K+currents, with no effect on voltage-gated Ca2+currents (Suzuki et al, 2007).
(3) The CaM-dependent IpCa inactivation during low-frequency stimulation, and the ensuing synaptic depression, occurs only at immature calyces, when a high intra-terminal Ca2+concentration can be attained during low frequency stimulation (Nakamura et al, 2008).
(4) Contribution of AMPAR desensitization to paired-pulse depression decreased after hearing onset, concomitantly with a developmental declines of GluR1 expression and transmitter release probability, indicating that both pre- and postsynaptic mechanisms contribute to the involvement of AMPAR desensitization in short-term synaptic depression (Koike-Tani et al, 2008).

  • Research Products

    (7 results)

All 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Remarks (1 results)

  • [Journal Article] Developmental changes in calcium/calmodulin-dependent inactivation of calcium currents at the rat calyx of Held2008

    • Author(s)
      Nakamura T, Yamashita T, Saitoh N, Takahashi T
    • Journal Title

      J. Physiol. 586

      Pages: 2253-2261

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Involvement of AMPA receptor desensitization in short-term synaptic depression at the calyx of Held in developing rats2008

    • Author(s)
      Koike-Tani M, Kanda T, Yamashita T, Takahashi T
    • Journal Title

      J. Physiol. 586

      Pages: 2263-2275

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Involvement of AMPA receptor desensitization in short-term synaptic depression at the calyx of Held in developing rats.2008

    • Author(s)
      Koike-Tani M, Kanda T, Yamashita T, Takahashi T
    • Journal Title

      J. Physiol. 586

      Pages: 2263-2275

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Developmental changes in potassium currents at the rat calyx of Held presynaptic terminal2007

    • Author(s)
      Nakamura Y, Takahashi T
    • Journal Title

      J. Physiol. 581

      Pages: 1101-1112

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Developmental changes in potassium currents at the rat calyx of Held presynaptic terminal2007

    • Author(s)
      Nakamura Y, Takahashi T
    • Journal Title

      J. Physiol. 581.3

      Pages: 1101-1112

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 4-Chloro-m-cresol, an activator of ryanodine receptors, inhibits voltage- gated K^+ channelsat the rat calyx of Held2007

    • Author(s)
      Suzuki D, Hori T, Saitoh N, Takahashi T
    • Journal Title

      Eur. J. Neurosci. 26

      Pages: 1530-1536

    • Description
      「研究成果報告書概要(欧文)」より
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://synapse.doshisha.ac.jp/

URL: 

Published: 2010-06-09  

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