• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2007 Fiscal Year Annual Research Report

プロテアソームの分子集合と多様性の解析

Research Project

Project/Area Number 17002019
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

田中 啓二  Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員 (10108871)

Co-Investigator(Kenkyū-buntansha) 村田 茂穂  東京大学, 大学院・薬学系研究科, 教授 (20344070)
Keywordsプロテアソーム / ユビキチン / ATP依存性プロテアーゼ / 分子集合 / 分子多様性 / ユビキチンリガーゼ / オートファジー / 胸腺特異的プロテアソーム
Research Abstract

プロテアソームはユビキチン(分解のための目印を形成する翻訳後修飾分子)をパートナーとする蛋白質分解のための大掛かりな細胞内装置である。本酵素は生命科学史上他に類を見ない巨大で複雑な多成分複合体(分子量2.5MDa,総サブユニット数約100個)である。本研究ではプロテアソームの分子集合機構と分子多様性の解明を基軸に蛋白質分解の生命科学における役割の解明を目指す。第1の課題である「プロテアソームの分子集合機構の解明」については,最近,我々が発見した哺乳動物の会合支援シャペロンであるPAC1/PAC2異型二量体に加えて,本年新たにPAC3/PAC4とプロテアソームとの共結晶による4次構造を決定し,これらのシャペロンの作動機構の解明にも成功した。これらの結果に基づいて我々はプロテアソームの分子集合に関する“逐次的多段階会合モデル"を提唱した。第2の課題である「プロテアソームの分子多様性の解析」については,約10年前に我々は構成型プロテアソーム以外に“免疫プロテアソーム"を発見し,この酵素が細胞性免疫の始動に関与していることを明らかにしたが,本年,第3のプロテアソームとして“胸腺プロテアソーム"を発見した。そして作出した遺伝子欠損マウスの解析から,胸腺プロテアソームがCD8^+リンパ球の分化に必須な役割を果たしていることを突き止めた。その結果,長い間免疫学における謎であった胸腺における“正に選択"の分子機構解明の糸口を掴んだ。その他,オートファジー(Self-Eating:自食作用)の破綻によって生じるユビキチン陽性の封入体形成機構を初めて明らかにした。これらの成果は,細胞内蛋白質の動態(輪廻転生)や病態解明の基盤となると共に,健康科学の発展にも大きく寄与する波及効果が期待される。

  • Research Products

    (100 results)

All 2008 2007 Other

All Journal Article (34 results) (of which Peer Reviewed: 34 results) Presentation (65 results) Remarks (1 results)

  • [Journal Article] Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury2008

    • Author(s)
      Koike, M., et. al.
    • Journal Title

      Am.J.Pathol 172

      Pages: 454-469

    • Peer Reviewed
  • [Journal Article] Muscle RING-Finger protein MuRFl as a connector of muscle energy metabolism and protein synthesis2008

    • Author(s)
      Koyama, S., et. al.
    • Journal Title

      J.Mol.Biol. 376

      Pages: 1224-1236

    • Peer Reviewed
  • [Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes2008

    • Author(s)
      Yashiroda, H., et. al.
    • Journal Title

      Nature Struct.Mol.Biol 15

      Pages: 228-236

    • Peer Reviewed
  • [Journal Article] A novel small-molecule inhibitor of NF-κB signaling2008

    • Author(s)
      Nakajima, H., et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun 368

      Pages: 1007-1013

    • Peer Reviewed
  • [Journal Article] Comprehensive proteomics analysis of autophagy-deficient mouse liver.Autophagy deficiency is associated with overexpression of stress-related proteins2008

    • Author(s)
      Matsumoto, N., et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun 68

      Pages: 1007-1013

    • Peer Reviewed
  • [Journal Article] Gp78 cooperates with RMAl in ER-associated degradation of CFTRΔF5082008

    • Author(s)
      Morito, Hirao, K., et. al.
    • Journal Title

      Mol Biol Cell 19

      Pages: 1328-1336

    • Peer Reviewed
  • [Journal Article] Structural basis for ubiquitin-fold modifier 1(ufm1) processing by ufm1 speicific protease,UFSP2008

    • Author(s)
      Ha BH, et. al.
    • Journal Title

      J Biol Chem 283

      Pages: 14893-14900

    • Peer Reviewed
  • [Journal Article] c-Cbl-dependent monoubiquitination and lysosomal degradation of gp1302008

    • Author(s)
      Tanaka, Y., et. al.
    • Journal Title

      Mol.Cell.Biol 28

      Pages: 4805-4818

    • Peer Reviewed
  • [Journal Article] Allele-selective effect of PA28 in MHC class I antigen processing2008

    • Author(s)
      Yamano, T., et. al.
    • Journal Title

      J.Immunol 181

      Pages: 1655-1664

    • Peer Reviewed
  • [Journal Article] Dissecting β-ring assembly pathway of the mammalian 20S Proteasome2008

    • Author(s)
      Hirano, Y., et. al.
    • Journal Title

      EMBO J 27

      Pages: 2204-2213

    • Peer Reviewed
  • [Journal Article] Cytoplasmic destruction of tumor suppressor gene p53 by the endoplasmic reticulum-resident ubiquitin ligase "Synoviolin"2007

    • Author(s)
      Yamasaki, S., et. al.
    • Journal Title

      EMBOJ 26

      Pages: 113-122

    • Peer Reviewed
  • [Journal Article] Ihvolvement of PA28□-Dependent Pathway in Insulin Resistance Induced by Hepatitis C Vuus Core Protein 32007

    • Author(s)
      Miyamoto, H., et. al.
    • Journal Title

      J.Virol 81

      Pages: 1727-1735

    • Peer Reviewed
  • [Journal Article] The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome2007

    • Author(s)
      Isono, E., et. al.
    • Journal Title

      Mol Biol Cell 18

      Pages: 569-580

    • Peer Reviewed
  • [Journal Article] Cdtical role of PA28□ in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis2007

    • Author(s)
      Moriishi, K., et. al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 104

      Pages: 1661-1666

    • Peer Reviewed
  • [Journal Article] Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-reulation of cullin-based E3 liase activity2007

    • Author(s)
      Sakata, E., et. al.
    • Journal Title

      Nature Struct.Mol.Biol 14

      Pages: 167-168

    • Peer Reviewed
  • [Journal Article] Two novel ubiquitin-fold modifier 1(Ufm1)-specific proteases, UfSP1 and UfSP22007

    • Author(s)
      Kang, S.H., et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 5256-5262

    • Peer Reviewed
  • [Journal Article] A Neural-specific F-box protein Fbsl functions as a chaperone suppressing glycoprotein aggregation2007

    • Author(s)
      Yoshida, Y., et. al.
    • Journal Title

      J.Biol.Chem 282

      Pages: 7137-7144

    • Peer Reviewed
  • [Journal Article] TBP-interacting protein 120b(TIP120B)/cullin-associated and neddylation-dissociated 2(CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiaton2007

    • Author(s)
      Shiraishi, S., et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 9017-9028

    • Peer Reviewed
  • [Journal Article] Structural basis for selection of glycosylated substrate by SCF^<Fbsl> ubiquitin ligase2007

    • Author(s)
      Mizushima, T., et. al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 104

      Pages: 5777-5781

    • Peer Reviewed
  • [Journal Article] Regulation of CD8^+ T cell development by thymus-specific proteasomes2007

    • Author(s)
      Murata, S., et. al.
    • Journal Title

      Science 316

      Pages: 1349-1353

    • Peer Reviewed
  • [Journal Article] Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration2007

    • Author(s)
      Komatsu M., et. al.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 14489-14494

    • Peer Reviewed
  • [Journal Article] SCRAPPER-dependent ubiquitination of active zone protein RIMl regulates synaptic vesicle release2007

    • Author(s)
      Yao, I., et. al.
    • Journal Title

      Cell 130

      Pages: 943-957

    • Peer Reviewed
  • [Journal Article] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development2007

    • Author(s)
      Hamazaki J., et. al.
    • Journal Title

      Mol.Cell.Biol 27

      Pages: 6629-6638

    • Peer Reviewed
  • [Journal Article] Fbs1 protects the malfolded glycoproteins from the attack of peptide:N-glycanase2007

    • Author(s)
      Yamaguchi, Y., et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun 362

      Pages: 712-716

    • Peer Reviewed
  • [Journal Article] Homeostatic levels of p62 control cytoplaslnic inclusion body formation in autopha-deficient mice2007

    • Author(s)
      Komatsu, M., et. al.
    • Journal Title

      Cell 131

      Pages: 1149-1163

    • Peer Reviewed
  • [Journal Article] Crystal structure of Ufc1,the Ufm1-conjugating enzyme2007

    • Author(s)
      Mizushima T., et.al.
    • Journal Title

      Biochem.Biophys.Res.Common 362

      Pages: 1079-1084

    • Peer Reviewed
  • [Journal Article] Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis2007

    • Author(s)
      Sanjuan, M.A., et. al.
    • Journal Title

      Nature 450

      Pages: 1253-1257

    • Peer Reviewed
  • [Journal Article] A novel ubiquitin ligase involved in p57^<Kip2> proteolysis regulates osteoblast cell differentiation

    • Author(s)
      Kim, M., et. al.
    • Journal Title

      EMBO Rep (in press)

    • Peer Reviewed
  • [Journal Article] Structural basis for sorting mechanism of p62 in selective autophagy

    • Author(s)
      Ichimura Y., et. al.
    • Journal Title

      J Biol Chem (In press)

    • Peer Reviewed
  • [Journal Article] Mammalian 26S proteasomes remain intact during protein degradation

    • Author(s)
      Kriegenburg, F., et. al.
    • Journal Title

      Cell (In press)

    • Peer Reviewed
  • [Journal Article] Autophagy in pancreatic beta cells is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

    • Author(s)
      Ebato, C., et. al.
    • Journal Title

      Cell Metab (In press)

    • Peer Reviewed
  • [Journal Article] Essential role of Macroautophagy in Pancreatic β-Cell Survival and Proliferation

    • Author(s)
      Jung, HS., et. al.
    • Journal Title

      Cell Metab (In press)

    • Peer Reviewed
  • [Journal Article] The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice

    • Author(s)
      Sou, Y., et. al.
    • Journal Title

      Mol Biol Cell (In press)

    • Peer Reviewed
  • [Journal Article] Hsp90 mediated assembly of the 26S proteasome is involved in MHC class I antigen processing

    • Author(s)
      Yamano T., et. al.
    • Journal Title

      J.Biol.Chem (In press)

    • Peer Reviewed
  • [Presentation] Role of p62/SQSTM1 degradation by autophagy in cytoplasmic inclusion formation2008

    • Author(s)
      Masaaki Komatsu
    • Organizer
      3th GRC ALTTOPHAGY IN STRESS, DEVELOPMENT AND DISEASE
    • Place of Presentation
      Ventura,CA,USA
    • Year and Date
      20080106-11
  • [Presentation] 新規F-boxタンパク質の標的分子の探索2007

    • Author(s)
      丸岡 裕子, 他
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      20071211-15
  • [Presentation] 糖鎖認識F-boxタンパク質Fbs1の神経細胞における機能の解析2007

    • Author(s)
      吉田 雪子, 他
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      20071211-15
  • [Presentation] ノックアウトマウスを用いたN型糖鎖を認識するSCF^<FBG2>ユビキチンリガーゼの機能解析2007

    • Author(s)
      吉田 雪子, 他
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      20071211-15
  • [Presentation] 哺乳類20Sプロテアソームの段階的な形成機構について2007

    • Author(s)
      平野 祐子, 他
    • Organizer
      第30回日本分子生物学会第80回生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      20071211-15
  • [Presentation] 出芽酵母20Sプロテアソーム形成に関わる纈シャペロン複合体2007

    • Author(s)
      八代田 英樹, 他
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      20071211-15
  • [Presentation] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice2007

    • Author(s)
      Masaaki Komatsu, et. al.
    • Organizer
      国際シンポジウム「メンブレントラフィック」
    • Place of Presentation
      Awajishima Hyogo,Japan
    • Year and Date
      20071127-29
  • [Presentation] The role of Atg8 conjugation system in mice2007

    • Author(s)
      Yu-shin Sou, et. al.
    • Organizer
      国際シンポジウム「メンブレントラフィック」
    • Place of Presentation
      Awajishima Hyogo,Japan
    • Year and Date
      20071127-29
  • [Presentation] The role of Atg8 conjugation system in mice2007

    • Author(s)
      Yu-shin Sou, et. al.
    • Organizer
      第20回内藤カンファレンス「自然免疫の医学・生物学〔III〕」
    • Place of Presentation
      Kanagawa,Japan
    • Year and Date
      20071109-12
  • [Presentation] Discovery of Thymus-specific Proteasomes "Thymoproteasome" that regalate the Development of CD8^+ T Cells2007

    • Author(s)
      Keiji Tanaka
    • Organizer
      Intemational Symposium on Protein Modification and Degradafion in Beijing, SPMDB 2007
    • Place of Presentation
      Beijing Friendship Hotel,Beijing,China
    • Year and Date
      20071104-07
  • [Presentation] Mechanism of assembly of mammalian 20S proteasomes2007

    • Author(s)
      Yuko Hirano
    • Organizer
      SPN-DB2007(short talk)
    • Place of Presentation
      Beijing,China
    • Year and Date
      20071104-07
  • [Presentation] Ufm1-conjugating system is essential for erythropoiesis2007

    • Author(s)
      Kanako Tatsumi., et. al.
    • Organizer
      2007 INTERNATIONAL SYMPOSIUM ON PROTEIN MODIFICATION AND DEGRADATION IN BEIJING(SPMDB2007)Poster No.3.5
    • Place of Presentation
      Beijing,China
    • Year and Date
      20071104-07
  • [Presentation] 新しいユビキチン様修飾システムUfm1 systemの血液学的機能解析2007

    • Author(s)
      辰巳 加奈子, 他
    • Organizer
      第69回日本血液学会口演OS-40-1
    • Place of Presentation
      横浜
    • Year and Date
      20071011-13
  • [Presentation] Pathophysiology of Consitutive Autophagy2007

    • Author(s)
      Keiji Tanaka., et. al.
    • Organizer
      The 20th Naito Conference/Innate Immunity in Medicine and Biology [III]
    • Place of Presentation
      湘南国際村センター神奈川
    • Year and Date
      20071010-12
  • [Presentation] Regulation of Thymic Selection by the Thymus-specific Proteasome "Thymoproteasome"2007

    • Author(s)
      Keiji Tanaka., et. al.
    • Organizer
      EMBO CONFERENCE/Ubiquitin and Ubiqutin-like Modifiers in Cellular Regulation
    • Place of Presentation
      Riva Del Garda,Italy
    • Year and Date
      20070922-26
  • [Presentation] Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase2007

    • Author(s)
      Yuko Maruoka., et. al.
    • Organizer
      EMBO Conference 'Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation'
    • Place of Presentation
      Riva del Garda,Italy
    • Year and Date
      20070922-26
  • [Presentation] Novel functions of a neural-specific F-box protein Fbs12007

    • Author(s)
      Yukiko Yoshida., et. al.
    • Organizer
      EMBO Conference 'Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation'
    • Place of Presentation
      Riva del Garda,Italy
    • Year and Date
      20070922-26
  • [Presentation] ユニークな蛋白質分解システム・プロテアソームとオートファジー2007

    • Author(s)
      田中 啓二
    • Organizer
      第11回Molecular Cardiovascular Conference
    • Place of Presentation
      キロロ"ホテルピアノ"北海道余市郡赤井川村
    • Year and Date
      20070914-16
  • [Presentation] 20Sプロテアソーム会合支援複合体Dmp1/Dmp2の解析2007

    • Author(s)
      八代田 英樹, 他
    • Organizer
      第40回酵母遺伝学フォーラム
    • Place of Presentation
      大阪
    • Year and Date
      20070911-13
  • [Presentation] 哺乳類における20S Proteasomeの分子集合機構について2007

    • Author(s)
      平野 祐子, 他
    • Organizer
      病態と治療におけるプロテアーゼとインヒビター学会
    • Place of Presentation
      大阪
    • Year and Date
      20070803-04
  • [Presentation] Dciscovery of thymus-specific proteasomes"thymoproteasomes"that regulate the development of CDB+T cells2007

    • Author(s)
      Keiji Tanaka., et. al.
    • Organizer
      COE INTERNATIONAL SYMPOSIUM 2007
    • Place of Presentation
      Inamori/Yamauchi Hall,Kyoto University Kyoto,Japan
    • Year and Date
      20070601-02
  • [Presentation] Protein Quality Control by Constitutive Autophag2007

    • Author(s)
      Keiji Tanaka., et. al.
    • Organizer
      The Ubiquitin Family (CSHS Symposium):Quality Control
    • Place of Presentation
      New York, USA
    • Year and Date
      20070425-29
  • [Presentation] Identification and characterization of novel proteasome associated proteins in S.cerevisiae2007

    • Author(s)
      Hideki Yashiroda, et. al.
    • Organizer
      The Ubiquitin Family
    • Place of Presentation
      Cold Spring Hafbor laboratory,USA
    • Year and Date
      20070425-29
  • [Presentation] Ufm1-conjugating system is essential for normal erythropoiesis2007

    • Author(s)
      Kanako Tatsumi., et. al.
    • Organizer
      The 2007 meeting on THE UBIQUITIN FAMILY Poster No.118
    • Place of Presentation
      Cold Spring Harbor,N.Y.USA
    • Year and Date
      20070425-29
  • [Presentation] PAC1/2/3 complex plays essential rule for the assembly of mammalian 20S proteasomes2007

    • Author(s)
      Yuko Hirana., et. al.
    • Organizer
      3rd Charite Zeuthener See workshop
    • Place of Presentation
      Berlin,Germany
    • Year and Date
      20070420-23
  • [Presentation] Selective Autophagy Regulates Formation of Intracvtonlamic Inclusions2007

    • Author(s)
      Masaaki Komatsu
    • Organizer
      Keystone Symposium on Autophagy in Health and Disease
    • Place of Presentation
      Monterey,CA,USA
    • Year and Date
      20070415-20
  • [Presentation] 蛋白質の輪廻転生・プロテアソームとオートファジーの世界2007

    • Author(s)
      田中 啓二
    • Organizer
      鹿児島大学生埋化学セミナー
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-12-21
  • [Presentation] ユビキチンの動態を制御する因子(Rfu1)の機能解析2007

    • Author(s)
      木村 洋子, 他
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
  • [Presentation] Regulation of positive selection of CD8 T cells by thymus-specific proteasomes2007

    • Author(s)
      村田 茂穂, 他
    • Organizer
      BMB2007(第30回日本分子生物学会, 第80回日本生化学会合同年会)
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
  • [Presentation] 平成19年度日本生化学会奨励賞受賞講演「プロテアソームによる適応免疫システム制御に関する研究」2007

    • Author(s)
      村田 茂穂
    • Organizer
      BMB2007(第30回日本分子生物学会, 第80回日本生化学会合同年会)
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
  • [Presentation] The role of Atg8 conjugation system in mice2007

    • Author(s)
      Yu-shin Sou, et. al.
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
  • [Presentation] 選択的オートファジLと封入体形成2007

    • Author(s)
      小松 雅明, 他
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
  • [Presentation] 平成18年度生化学会奨励賞受賞講演2007

    • Author(s)
      小松 雅明
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
  • [Presentation] 私のプロテアソーム研究-黎明期から成長期を辿って-2007

    • Author(s)
      田中 啓二
    • Organizer
      BMB2007マスターズレクチャー
    • Place of Presentation
      東京
    • Year and Date
      2007-12-12
  • [Presentation] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse develovment2007

    • Author(s)
      濱崎 純, 他
    • Organizer
      第30回日本分子生物学会年会、No.4P-0634
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
  • [Presentation] オートファジーによる制御2007

    • Author(s)
      田中 啓二
    • Organizer
      第2回臨床ストレス応答学会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-01
  • [Presentation] プロテアソームによる生体制御2007

    • Author(s)
      村田 茂穂
    • Organizer
      第2回臨床ストレス応答学会特別講演
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-01
  • [Presentation] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development2007

    • Author(s)
      Jun Hamazaki, et. al.
    • Organizer
      SPMDB2007 No.2-1
    • Place of Presentation
      Beijing,China
    • Year and Date
      2007-11-06
  • [Presentation] Regulation of positive selection of CD8 T cells by thymus-specific proteasomes2007

    • Author(s)
      Shigeo Murata, et. al.
    • Organizer
      第37回日本免疫学会総会Late Breaking symposium
    • Place of Presentation
      東京
    • Year and Date
      2007-11-02
  • [Presentation] タンパク質の輪廻転生と生命科学2007

    • Author(s)
      田中 啓二
    • Organizer
      東京大学医学部生化学・栄養学講義
    • Place of Presentation
      東京
    • Year and Date
      2007-10-29
  • [Presentation] プロテアソームの多様性による生命活動の制御とその分子基盤2007

    • Author(s)
      村田 茂穂
    • Organizer
      三菱生命研セミナー
    • Place of Presentation
      東京
    • Year and Date
      2007-10-25
  • [Presentation] 選択的オートファジーと凝集体形成2007

    • Author(s)
      小松 雅明
    • Organizer
      公開シンポジウム「オートファジー:病態に迫る!」
    • Place of Presentation
      東京
    • Year and Date
      2007-09-22
  • [Presentation] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development2007

    • Author(s)
      Jun Hamazaki, et. al.
    • Organizer
      EMBO conference:Ubiquitin and Ubiquitin-like modifiers in cellular regulation、No.32
    • Place of Presentation
      Riva del Garda,Italy
    • Year and Date
      2007-09-21
  • [Presentation] Discovery of Thymoproteasomes-Implication for Thymic Selection2007

    • Author(s)
      Keiji Tanaka
    • Organizer
      2007 Korea-Japan Joint Symposium in Seoul
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2007-09-05
  • [Presentation] Regulation of positive selection of CD8 T cell by thymus-specific proteasomes2007

    • Author(s)
      Shigeo Murata
    • Organizer
      The 7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Hyogo
    • Year and Date
      2007-09-03
  • [Presentation] オートファゴソームマーカーLC3システムにおけるE2様酵素Atg3欠損マウスの解析2007

    • Author(s)
      曽 友深, 他
    • Organizer
      第12回病態と治療におけるプロテアーゼとインヒビター学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-08-03
  • [Presentation] プロテアソームの分子集合2007

    • Author(s)
      村田 茂穂
    • Organizer
      第5回日本ヒトプロテオーム機構大会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-30
  • [Presentation] 蛋白質の輪廻転生と生命科学2007

    • Author(s)
      田中 啓二
    • Organizer
      京都大学医学部大学院講義
    • Place of Presentation
      京都
    • Year and Date
      2007-07-13
  • [Presentation] 蛋白質の輪廻転生と生命科学2007

    • Author(s)
      田中 啓二
    • Organizer
      東京都神経科学総合研究所セミナー
    • Place of Presentation
      東京
    • Year and Date
      2007-07-12
  • [Presentation] オートファジー(Self-eating)と神経変性疾患2007

    • Author(s)
      田中 啓二
    • Organizer
      第5回京都神経科学セミナー
    • Place of Presentation
      京都
    • Year and Date
      2007-07-03
  • [Presentation] 蛋白質の輪廻転生と免疫2007

    • Author(s)
      田中 啓二
    • Organizer
      九州大学医学部生命基礎医学免疫学各論講義
    • Place of Presentation
      福岡
    • Year and Date
      2007-07-02
  • [Presentation] プロテアソームの分子集合機構と分子多様性の解析2007

    • Author(s)
      田中 啓二
    • Organizer
      九州大学生体防御研究所セミナー
    • Place of Presentation
      福岡
    • Year and Date
      2007-07-02
  • [Presentation] プロテアソームの多様性による生命活動の制御とその分子基盤2007

    • Author(s)
      村田 茂穂
    • Organizer
      東京大学大学院薬学系研究科・生物系薬学セミナー
    • Place of Presentation
      東京
    • Year and Date
      2007-06-19
  • [Presentation] 蛋白質の輪廻転生と生命科学2007

    • Author(s)
      田中 啓二
    • Organizer
      日本大学大学院医学研究科平成19年度講義
    • Place of Presentation
      東京
    • Year and Date
      2007-06-16
  • [Presentation] 胸腺特異的プロテアソームによるCD8+T細胞分化制御2007

    • Author(s)
      村田 茂穂, 他
    • Organizer
      第17回KTCC
    • Place of Presentation
      京都
    • Year and Date
      2007-06-15
  • [Presentation] Regulation of positive selection of CD8 T cells by thymus-specific proteasomes2007

    • Author(s)
      Shigeo Murata
    • Organizer
      理化学研究所免疫アレルギー科学総合研究センター講演
    • Place of Presentation
      横浜
    • Year and Date
      2007-06-13
  • [Presentation] オートファジー欠損による凝集体形成機構2007

    • Author(s)
      小松 雅明
    • Organizer
      第59回日本細胞生物学会第40回日本発生生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-30
  • [Presentation] Molecular basis for the diversity of mammalian proteasomes2007

    • Author(s)
      村田 茂穂
    • Organizer
      第59回日本細胞生物学会、第40回日本発生生物学会合同年会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-29
  • [Presentation] タンパク質の品質管理と疾患そしてそのモデルマウス2007

    • Author(s)
      田中 啓二
    • Organizer
      第54回日本実験動物学会総会シンポジウム疾患モデルマウス:系統樹立と表現型解析の新潮流
    • Place of Presentation
      江戸川区民ホール・タワーホール船堀 東京
    • Year and Date
      2007-05-23
  • [Presentation] タンパク質の輪廻転生と生命科学2007

    • Author(s)
      田中 啓二
    • Organizer
      メディカルゲノム専攻「システム細胞情報論」平成19年度講義
    • Place of Presentation
      医科研一号館・一階講堂 東京
    • Year and Date
      2007-05-11
  • [Presentation] Impaired degradation of ubiquitinated proteins in Rpn10-deficient mice2007

    • Author(s)
      Riva del Garda, Italy
    • Organizer
      THE UBIQUITIN FAMILY meeting、No.57
    • Place of Presentation
      Cold Spring Harbor,New York
    • Year and Date
      2007-04-30
  • [Presentation] Thymoproteasomes regulate development of CD8+ T cells in the thymus2007

    • Author(s)
      Shigeo Murata
    • Organizer
      3rd Zeuthener See Workshop 2007
    • Place of Presentation
      Berlin
    • Year and Date
      2007-04-23
  • [Presentation] Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes2007

    • Author(s)
      Shigeo Murata
    • Organizer
      Koloquium in Universitatsmedizin Berlin
    • Place of Presentation
      Berlin
    • Year and Date
      2007-04-19
  • [Presentation] 蛋白質の死を決定する分解装置、第27会日本医学会総会2007・シンポジウム2007

    • Author(s)
      田中 啓二
    • Organizer
      蛋白質の死と病気"ユビキチン・プロテアソームとオートファジー"
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-06
  • [Presentation] 蛋白質の輪廻転生と生命科学2007

    • Author(s)
      田中 啓二
    • Organizer
      大阪大学微生物病研究所学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2007-02-07
  • [Remarks]

    • URL

      http://www.rinshoken.or.jp/

URL: 

Published: 2010-02-04   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi