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2009 Fiscal Year Final Research Report

Informatory expression system connecting cancer and immunity.

Research Project

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Project/Area Number 17012005
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

TANIGUCHI Tadatsugu  The University of Tokyo, 大学院・医学系研究科, 教授 (50133616)

Co-Investigator(Kenkyū-buntansha) TAKAOKA Akinori  北海道大学, 遺伝子病制御研究所, 教授 (30323611)
TAMURA Tonohiko  東京大学, 大学院・医学系研究科, 准教授 (50285144)
HONDA Kenya  東京大学, 大学院・医学系研究科, 助手 (60334231)
OOBA Yuusuke  東京大学, 大学院・医学系研究科, 助手 (30333503)
YANAI Hideyuki  東京大学, 大学院・医学系研究科, 助教 (70431765)
Project Period (FY) 2005 – 2009
Keywordsインターフェロン / IRFファミリー / p53 / 樹状細胞 / 発がん抑制 / Noxa / Puma / Toll様受容体
Research Abstract

We investigated biological mechanisms and role of effecter molecules, e.g. interferons, IRFs and Noxa. It revealed that these molecules are involved in transformation, apoptosis induction and metastasis signaling pathways. We also found the cross-talk pathway between TLRs signaling. Moreover, we identified DAI and HMGB1, 2, 3 are important for the nucleic-acid mediated innate immune responses. Since these pathways regulate tumorgenesis and exacerbation, our findings will be proved to be useful for the development of novel tumor therapy in near future.

  • Research Products

    (43 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (15 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Regulation of immunity and oncogenesis by the IRF transcription factor family.2010

    • Author(s)
      Savitsky D, Tamura T, Yanai H, Taniguchi T.
    • Journal Title

      Cancer Immunol. Immunother. Vol.59

      Pages: 489-510

    • Peer Reviewed
  • [Journal Article] HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses.2009

    • Author(s)
      Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani R, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T.
    • Journal Title

      Nature Vol.462

      Pages: 99-103

    • Peer Reviewed
  • [Journal Article] A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.2009

    • Author(s)
      Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, Taniguchi T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA Vol.106

      Pages: 17870-17875

    • Peer Reviewed
  • [Journal Article] Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene.2009

    • Author(s)
      Nakajima A, Nishimura K, Nakaima Y, Oh T, Noguchi S, Taniguchi T, Tamura T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA Vol.106

      Pages: 12448-12452

    • Peer Reviewed
  • [Journal Article] Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells.2009

    • Author(s)
      Suzuki S, Nakasato M, Shibue T, Koshima I, Taniguchi T.
    • Journal Title

      Cancer Sci. Vol.100

      Pages: 759-769

    • Peer Reviewed
  • [Journal Article] Critical role for constitutive type I interferon signaling in the prevention of cellular transformation.2009

    • Author(s)
      Chen HM, Tanaka N, Mitani Y, Oda E, Nozawa H, Chen JZ, Yanai H, Negishi H, Choi MK, Iwasaki T, Yamamoto H, Taniguchi T, Takaoka A.
    • Journal Title

      Cancer Sci. Vol.100

      Pages: 449-456

    • Peer Reviewed
  • [Journal Article] Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.2009

    • Author(s)
      Yanai H, Savitsky D, Tamura T, Taniguchi T.
    • Journal Title

      Curr. Opin. Immunol. Vol.1

      Pages: 17-22

    • Peer Reviewed
  • [Journal Article] A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.2008

    • Author(s)
      Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA Vol.105

      Pages: 20446-20451

    • Peer Reviewed
  • [Journal Article] The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and T(H)1 versus T(H)-17 differentiation of CD4(+) T cells.2008

    • Author(s)
      Kano S, Sato K, Morishita Y, Vollstedt S, Kim S, Bishop K, Honda K, Kubo M, Taniguchi T.
    • Journal Title

      Nat. Immunol. Vol.9

      Pages: 34-41

    • Peer Reviewed
  • [Journal Article] Interferon regulatory factor family of transcription factors and regulation of oncogenesis.2008

    • Author(s)
      Takaoka A, Tamura T, Taniguchi T.
    • Journal Title

      Cancer Sci. Vol.99

      Pages: 467-478

    • Peer Reviewed
  • [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling.2008

    • Author(s)
      Mizutani T, Tsuji K, Ebihara Y, Taki S, Ohba Y, Taniguchi T, Honda K.
    • Journal Title

      Exp. Hematol. Vol.36

      Pages: 255-264

    • Peer Reviewed
  • [Journal Article] A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis.2008

    • Author(s)
      Couzinet A, Tamura K, Chen HM, Nishimura K, Wang Z, Morishita Y, Takeda K, Yagita H, Yanai H, Taniguchi T, Tamura T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA Vol.105

      Pages: 2556-2561

    • Peer Reviewed
  • [Journal Article] The IRF Family Transcription Factors in Immunity and Oncogenesis. Annu.2008

    • Author(s)
      Tamura T, Yanai H, Savitsky D, Taniguchi T.
    • Journal Title

      Rev. Immunol. Vol.26

      Pages: 535-584

    • Peer Reviewed
  • [Journal Article] Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.2008

    • Author(s)
      Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA Vol.105

      Pages: 5477-5482

    • Peer Reviewed
  • [Journal Article] Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.2007

    • Author(s)
      Yanai H., Chen H., Inuzuka T., Kondo S., Mak WT., Takaoka A., Honda K. Taniguchi T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA Vol.104

      Pages: 3402-3407

    • Peer Reviewed
  • [Journal Article] DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.2007

    • Author(s)
      Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T.
    • Journal Title

      Nature Vol.448

      Pages: 501-505

    • Peer Reviewed
  • [Journal Article] Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism.2007

    • Author(s)
      Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H, Fujita T.
    • Journal Title

      J. Biol. Chem. Vol.282

      Pages: 7576-7581

    • Peer Reviewed
  • [Journal Article] Differential contribution of Puma and Noxa in dual regulation of p53-dependent apoptotic pathways.2006

    • Author(s)
      Shibue T, Suzuki S, Okamoto H, Yoshida H, Ohba Y, Takaoka A, Taniguchi T.
    • Journal Title

      EMBO J. Vol.25

      Pages: 4952-4962

    • Peer Reviewed
  • [Journal Article] BH3-only proteins: Integrated control point of apoptosis.2006

    • Author(s)
      Shibue T, Taniguchi T.
    • Journal Title

      Int. J. Cancer Vol.119

      Pages: 2036-2043

    • Peer Reviewed
  • [Journal Article] Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.2006

    • Author(s)
      Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, Takayanagi H, Ohba Y, Taniguchi T, Honda K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA Vol.103

      Pages: 15136-15141

    • Peer Reviewed
  • [Journal Article] IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.2006

    • Author(s)
      Honda K, Taniguchi T.
    • Journal Title

      Nat. Rev. Immunol. Vol.6

      Pages: 644-659

    • Peer Reviewed
  • [Journal Article] Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.2005

    • Author(s)
      Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TM, Taniguchi T.
    • Journal Title

      Nature Vol.434

      Pages: 243-249

    • Peer Reviewed
  • [Journal Article] IRF-7 is the master regulator of type-I interferon-dependent immune responses.2005

    • Author(s)
      Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T.
    • Journal Title

      Nature Vol.434

      Pages: 772-777

    • Peer Reviewed
  • [Journal Article] Spatiotemporal regulation of MmyD88-IRF-7 signalling for robust type I interferon induction.2005

    • Author(s)
      Honda K, Ohba Y, Yanai H, Negishi H, Mizutani T, Takaoka A, Taya C, Taniguchi T.
    • Journal Title

      Nature Vol.434

      Pages: 1035-1040

    • Peer Reviewed
  • [Journal Article] Negative regulation of Toll-like-receptor signaling by IRF-4.2005

    • Author(s)
      Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K, Matsuyama T, Taniguchi T, Honda K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA Vol.102

      Pages: 15989-15994

    • Peer Reviewed
  • [Journal Article] Type I interferon system and IRF family of transcription factors in host defense regulation.2005

    • Author(s)
      Taniguchi T, Takaoka A.
    • Journal Title

      Proc. Jpn. Acad. Vol.81

      Pages: 1-13

    • Peer Reviewed
  • [Journal Article] Regulation of the type I IFN induction: a current view.2005

    • Author(s)
      Honda K, Yanai H, Takaoka A, Taniguchi T.
    • Journal Title

      Int. Immunol. Vol.17

      Pages: 1367-1378

    • Peer Reviewed
  • [Presentation] Nucleic acid sensing and activation of innate and adaptive immune responses.2010

    • Author(s)
      Taniguchi T.
    • Organizer
      World Immune Regulation Meeting IV
    • Place of Presentation
      Davos, Switzerland
    • Year and Date
      20100329-20100401
  • [Presentation] Nucleic Acids-Sensing, Signaling and IRF Transcription Factors in Inflammation and Immunity.2009

    • Author(s)
      Taniguchi T.
    • Organizer
      The 9th World Congress on Inflammation
    • Place of Presentation
      東京
    • Year and Date
      20090706-20090710
  • [Presentation] Nucleic Acids Sensing, IRFs and Interferons: Implication in Protective and Pathological Immunities.2009

    • Author(s)
      Taniguchi T.
    • Organizer
      米国臨床免疫学講座学会
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20090611-20090614
  • [Presentation] Activation of innate immune responses by nucleic acids and IRFs.2009

    • Author(s)
      Taniguchi T.
    • Organizer
      Immune Regulation
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      20090525-20090527
  • [Presentation] Sencing, signaling and transcription in the innate immune response2008

    • Author(s)
      Taniguchi T.
    • Organizer
      The 6th Congress of the Chinese Society for Immunology
    • Place of Presentation
      西安、中華人民共和国
    • Year and Date
      20081031-20081103
  • [Presentation] Cytoplasmic receptors for the perception of danger2008

    • Author(s)
      Taniguchi T.
    • Organizer
      1st International Conference on Immunochemotherapy
    • Place of Presentation
      Paris, France
    • Year and Date
      20081017-20081018
  • [Presentation] 30 Years After the Dawn of Cytokine Molecular Biology: Roles of IRF Transcription Factors2008

    • Author(s)
      Taniguchi T.
    • Organizer
      Cytokines 2008-7th Joint Conference of the International Society for Interferon and Cytokine Research and International Cytokine Society
    • Place of Presentation
      モントリオール(カナダ)
    • Year and Date
      20081012-20081016
  • [Presentation] Regulation of Innate Immune Responses by DAI (DLM-1/ ZBP1) and Other DNA-semsing Molecules.2008

    • Author(s)
      Wang Z., et al.
    • Organizer
      7th Joint Conference of the International Society for Interferon and Cytokine Research and International Cytokine Society
    • Place of Presentation
      モントリオール(カナダ)
    • Year and Date
      20081012-20081016
  • [Presentation] 核酸認識による免疫系の活性化.2008

    • Author(s)
      Taniguchi T.
    • Organizer
      Toll 2008国際会議
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      20080824-20080827
  • [Presentation] The IRF family transcription factors in oncogenes and immunity.2008

    • Author(s)
      Taniguchi T.
    • Organizer
      Molecular biology of cancer: 20 years of progress punctuated by the Pezcoller Symposia
    • Place of Presentation
      in Trento, Italy
    • Year and Date
      20080611-20080613
  • [Presentation] Senseing, signaling and transcription in innate immune responses.2008

    • Author(s)
      Taniguchi T.
    • Organizer
      1st International-Singapore Symposium of Immunology
    • Place of Presentation
      Biopolis, Singapore
    • Year and Date
      20080112-20080116
  • [Presentation] Interferons and DNA Sensors2008

    • Author(s)
      Taniguchi T.
    • Organizer
      Perspectives in Immunology Symposium
    • Place of Presentation
      California, USA
    • Year and Date
      2008-05-12
  • [Presentation] IRF-5の抗ウイルス応答及び抗腫瘍応答における役割2007

    • Author(s)
      柳井秀元.
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      20071003-20071005
  • [Presentation] IRFs in Innate Immune Signaling.2007

    • Author(s)
      Taniguchi T.
    • Organizer
      Interacademy Symposium: innate immunity and its interface with adaptive immunity
    • Place of Presentation
      France
    • Year and Date
      20070802-20070805
  • [Presentation] Regulation of immune response and tumor suppression by the IRF family transcription factors.2007

    • Author(s)
      Taniguchi T.
    • Organizer
      International Conference on Immunology
    • Place of Presentation
      China
    • Year and Date
      20070712-20070715
  • [Patent(Industrial Property Rights)] 核酸により活性化される自然免疫応答の抑制剤およびそのスクリーニング方法

    • Inventor(s)
      谷口維紹
    • Industrial Property Rights Holder
      谷口維紹
    • Industrial Property Number
      特許・特願2009-238606

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Published: 2011-06-18   Modified: 2016-04-21  

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