2009 Fiscal Year Final Research Report
Molecular mechanisms of development of stomach cancer by Epstein-Barr virus
| Project/Area Number |
17013002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAKADA Kenzo Hokkaido University, 遺伝子病制御研究所, 教授 (30133721)
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| Co-Investigator(Kenkyū-buntansha) |
MARUO Seiji 北海道大学, 遺伝子病制御研究所, 准教授 (70292018)
IWAKIRI Dai 北海道大学, 遺伝子病制御研究所, 助教 (10307853)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 胃がん / ウイルス / RNA / サイトカイン / 自然免疫 / 分子機構 / EBウイルス |
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| Research Abstract |
In most people, Epstein-Barr virus (EBV) is maintained without specific manifestations, but is occasionally associated with various malignancies including lymphoma in immunodeficient hosts and gastric carcinoma. Previously, we have reported that EBV-encoded non-coding RNA (EBER) plays critical roles in oncogenesis. In this research, we have demonstrated that EBER exerts its oncogenic activity by utilizing an innate immunity system.
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[Journal Article] Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3.2009
Author(s)
Iwakiri, D., Zhou, L., Samanta, M., Matsumoto, M., Ebihara, T., Seya, T., Imai, S., Fujieda, M., Kawa, K., Takada, K.
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Journal Title
J. Exp. Med. 206
Pages: 2091-2099
Peer Reviewed
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[Journal Article] Epstein-Barr virus (EBV)-encoded BARF1 gene is expressed in nasopharyngeal carcinoma and EBV-associated gastric carcinoma tissues in the absence of lytic gene expression: implication of a new EBV latency type.2005
Author(s)
Seto, E., Yang, L., Middeldorp, J., Sheen, J.S., Chen, J.Y., Eizuru, Y., Takada, K.
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Journal Title
J. Med. Virol. 76
Pages: 82-88
Peer Reviewed
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