細胞の癌化とその抑制における転写因子の役割

2007 Fiscal Year Annual Research Report

• Project/Area Number: 17013017
• Research Institution: Tohoku University
• Principal Investigator: 山本 雅之 Tohoku University, 大学院・医学系研究科, 教授 (50166823)
• Co-Investigator(Kenkyū-buntansha): 清水 律子 筑波大学, 大学院・人間総合科学研究科, 講師 (40226262)
• Keywords: 多段階発がん / GATA1 / 巨核芽球白血病 / ダウン症候群 / 一過性骨髄増殖症 / 前赤芽球性性白血病 / 質的異常 / 量的異常

Research Abstract

本研究は、発がん防御という視点に焦点を絞り,転写因子機能を総合的に理解することを目的としている。本年度は、血球前駆細胞の増殖・分化・アポトーシスの制御を介して赤血球および巨核球の形成過程において重要な転写因子GATA1に着目し、マウス個体を用いた解析を行った。近年、N末端領域を欠失したGATA1変異が、ダウン症候群患児に発症する一過性骨髄増殖症(TMD)や、ひきつづく巨核芽球性白血病(AMKL)の芽球にほぼ必発していることから、自血病発症にかかわるGATAI変異の関与が注目されている。私たちは、同様なGATA1変異をもつマウスでは、TMD患児と同様に、胎生期から新生児期に未熟な巨核芽球が著明に蓄積しているが、この表現型は出生後すみやかに消失することを見いだした。また、ヒト症例と異なり、成獣マウスでは白血病を発症しないことを見いだした。このことは、GATA1単独変異によりTMDが発症しうるが、AMKLの発症には、21番染色体トリソミーに起因する他の遺伝子異常が引き金となることを示唆している。私たちは以前、GATA1ノックダウンマウスの解析を通して、GATA1の発現量の低下により、赤血球前駆細胞が蓄積し、その中の一部のマウスが前赤芽球性白血病を発症すること報告した。これらの結果は、GATA1の量的異常(発現量の低下)と質的異常(構造異常)が、それぞれ系列特異的な未熟な前駆細胞の蓄積を招来し、白血病発症の素地を作ること、さらに、それぞれの白血病発症には、GATA1変異にさらなる未知の遺伝子変異が関与している可能性を示唆している。

Research Products

• [Journal Article] Impairment of erythroid and megakaryocytic differentiation by a leukemia -associated and t(9; 9)-derived fusion gene product, SET/TAF-Ib-CAN/Nup 214. (2008)
  • Author(s): Saito S, Nouno K, Shimizu R, Yamamoto M, and Nagata K.
  • Journal Title: J Cell Physiol. 214 Pages: 322-333
  • Peer Reviewed
• [Journal Article] GATA-1の機能異常と白血病-Leukemogenesis related to GATA-1 mutation- (2008)
  • Author(s): 安倍加奈子、清水律子、山本雅之
  • Journal Title: 日本産婦人科血液学会誌 17 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Characterization of GATA-1^+ hemangioblastic cells in the mouse embryo. (2007)
  • Author(s): Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, and Yamamoto M.
  • Journal Title: EMBO J. 26 Pages: 184-196
  • Peer Reviewed
• [Journal Article] Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo [4, 5-f] quinoline. (2007)
  • Author(s): Kitamura Y, Umemura T, kanki K, Kodama Y, Kitamoto S, Saito K, Itoh K, Yamamoto M, Masegi T, Nishikawa A, and Hirose M.
  • Journal Title: Cancer Sci. 98 Pages: 19-24
  • Peer Reviewed
• [Journal Article] Shear stress stabilizes NF-E2 related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species. (2007)
  • Author(s): Warabi E, Takabe W, Minami T, Inoue K, Itoh K, Yamamoto M, Ishii T, Kodama T, and Noguchi N.
  • Journal Title: Free Rad Biol Med. 42 Pages: 260-269
  • Peer Reviewed
• [Journal Article] Inchinkoto, an herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in ratlivers. (2007)
  • Author(s): Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y and Suzuki H.
  • Journal Title: Am J Physiol Gastrointestinal Liver Physiol. 295 Pages: 1450-1463
  • Peer Reviewed
• [Journal Article] Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. (2007)
  • Author(s): Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, and Kensler TW.
  • Journal Title: Mol Cancer Therapeutics. 6 Pages: 154-161
  • Peer Reviewed
• [Journal Article] Does K-11706 enhance performance and why? (2007)
  • Author(s): Imagawa S, Matsumoto K, Horie M, Ohkoshi N, Nagasawa T, Doi T, Suzuki N, and Yamamoto M.
  • Journal Title: Int J Sports Med. 28 Pages: 928-933
  • Peer Reviewed
• [Journal Article] Functional polymorphisms in the transcription factor NRF2 increase the risk of acute lung injury. (2007)
  • Author(s): Marzec JM, Christie JD, Reddy SP, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Yamamoto T, Yamamoto M, Cho, H-Y, and Kleeberger SR.
  • Journal Title: FASEB J. 21 Pages: 2237-2246
  • Peer Reviewed
• [Journal Article] Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t (8;21)(q24;q22) acute myeloid leukemia. (2007)
  • Author(s): Asou N, Yanagida M, Huang L, Yamamoto M, Shigesada K, Mitsuya H, Ito Y, and Osato M.
  • Journal Title: Blood. 109 Pages: 4023-4027
  • Peer Reviewed
• [Journal Article] Cell cycle-dependent oscillation of GATA2 expression in hematopoietic cells. (2007)
  • Author(s): Koga S, Yamaguchi N, Abe T, Minegishi M, Tsuchiya S, Yamamoto M, and Minegishi N.
  • Journal Title: Blood. 109 Pages: 4200-4208
  • Peer Reviewed
• [Journal Article] Dynamic regulation of Gata factor levels is more important than their identity. (2007)
  • Author(s): Ferreira R, Wai A, Shimizu R, Gillemans N, Rottier R, von Lindem M, Ohneda K, Grosveld F, Yamamoto M, and Philipsen S.
  • Journal Title: Blood. 109 Pages: 5481-5490
  • Peer Reviewed
• [Journal Article] Nrf2 Neh5 domain is differentially utilized in the transactivation of cytop rotective genes. (2007)
  • Author(s): Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, and Yamamoto M.
  • Journal Title: Biochem J. 404 Pages: 459-466
  • Peer Reviewed
• [Journal Article] A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. (2007)
  • Author(s): Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim K-C, and Engel JD.
  • Journal Title: Development. 139 Pages: 1703-1712
  • Peer Reviewed
• [Journal Article] Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. (2007)
  • Author(s): Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, . Chen YT, Chang C, Yamamoto M, Tanimoto K, Engel JD.
  • Journal Title: EMBO J. 26 Pages: 2295-2306
  • Peer Reviewed
• [Journal Article] GATA-1 self-association controls erythroid development in vivo. (2007)
  • Author(s): Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, and Yamamoto M.
  • Journal Title: J Biol Chem. 282 Pages: 15862-15871
  • Peer Reviewed
• [Journal Article] Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. (2007)
  • Author(s): Reddy NM, Kleeberger SR, Cho H-Y, Yamamoto M, Kensler TW, Biswal S, and Reddy SP.
  • Journal Title: Am J Res Cell Mol Biol. 37 Pages: 3-8
  • Peer Reviewed
• [Journal Article] Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. (2007)
  • Author(s): Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S.
  • Journal Title: Neuroscience. 147 Pages: 53-59
  • Peer Reviewed
• [Journal Article] Enhanced spontaneous and benzo[α]pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice. (2007)
  • Author(s): Aoki Y, Hashimoto AH, Amanuma K, Matsumoto M, Hiyoshi K, Takano H, Masumura K, Itoh K, Nohmi T and Yamamoto M.
  • Journal Title: Cancer Res. 67 Pages: 5643-5648
  • Peer Reviewed
• [Journal Article] Oxidative and electrophilic stress induces Mrp transporters via the Nrf2 transcriptional pathway. (2007)
  • Author(s): Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, and Klaassen CD.
  • Journal Title: Hepatology. 46 Pages: 1597-1610
  • Peer Reviewed
• [Journal Article] Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. (2007)
  • Author(s): Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S.
  • Journal Title: Free Rad Biol Med. 43 Pages: 408-414
  • Peer Reviewed
• [Journal Article] Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis. (2007)
  • Author(s): Iida K, Itoh K, Maher JM, Kumagai Y, Oyasu R, Mori Y, Fukushima S, Shimazui T, Akaza H, and Yamamoto M.
  • Journal Title: Carcinogenesis. 28 Pages: 2398-2403
  • Peer Reviewed
• [Journal Article] NRF2 modulates ary1 hydrocarbon receptor signaling: Influence on adipogenesis. (2007)
  • Author(s): Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, and Kensler TW.
  • Journal Title: Mol Cell Biol. 27 Pages: 7188-7197
  • Peer Reviewed
• [Journal Article] Different Electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. (2007)
  • Author(s): Tong KI, Padmanabhan B, Kobayashi A, Shang C, Hirotsu Y, Yokoyama S, and Yamamoto M.
  • Journal Title: Mol Cell Biol. 27 Pages: 7511-7521
  • Peer Reviewed
• [Journal Article] Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. (2007)
  • Author(s): Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, and Kensler TW.
  • Journal Title: Int J Cancer. 121 Pages: 1883-1891
  • Peer Reviewed
• [Journal Article] Subcellul localization and cytoplasmic complex status of endogenous Keapl. (2007)
  • Author(s): Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, and Yamamoto M.
  • Journal Title: Genes Cells. 12 Pages: 1163-1178
  • Peer Reviewed
• [Journal Article] In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression. (2007)
  • Author(s): Takeuchi Y, Yahagi N, Nakagawa Y, Matsuzaka T, Shimizu R, Sekiya M, Iizuka Y, Ohashi K, Gotoda T, Yamamoto M, Nagai R, Kadowaki T, Yamada N, Osuga JI, and Shimano H.
  • Journal Title: Biochem Biophys Res Commun. 363 Pages: 329-335
  • Peer Reviewed
• [Journal Article] Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity. (2007)
  • Author(s): Toyama T, Sumi D, Shinkai Y, Yasutake A, Taguchi K, Tong KI, Yamamoto M, and Kumagai Y.
  • Journal Title: Biochem Biophys Res Commun. 363 Pages: 645-650
  • Peer Reviewed
• [Journal Article] Potential involvement of pathophysiologically formed 8-nitroguanosine 3', 5'-cyclic monophosphate in nitric oxide-induced signal transduction. (2007)
  • Author(s): Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, and Akaike T.
  • Journal Title: Nature Chem Biol. 3 Pages: 727-735
  • Peer Reviewed
• [Journal Article] The N-terminal homology box 1 (NHB1) sequence in transcription factor Nrfl is required to anchor it to the endoplasmic reticulum and also to enable its Asn-glycosylation. (2007)
  • Author(s): Zhang Y, Lucocq JM, Yamamoto M, and Hayes JD.
  • Journal Title: Biochem J. 408 Pages: 161-172
  • Peer Reviewed
• [Journal Article] The TR2 and TR4 orphan nuclear receptors repress Gatal transcription. (2007)
  • Author(s): Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, and Engel JD.
  • Journal Title: Genes Dev. 21 Pages: 2832-2844
  • Peer Reviewed
• [Journal Article] Loss of p62/SQSTM1 suppresses cytoplasmic inclusion body formation and liver injury in autophagy-deficient mouse. (2007)
  • Author(s): Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E and Tanaka K
  • Journal Title: Cell. 131 Pages: 1149-1163
  • Peer Reviewed
• [Journal Article] Molecular basis distinguishing the DNA binding profile of NRF2-MAF heterodimer from that of MAF homodimer. (2007)
  • Author(s): Kimura M, Yamamoto T, Zhang J, Itoh K, Kyo M, Kamiya T, Aburatani H, Katsuoka F, Kurokawa H, Tanaka T, Motohashi H, and Yamamoto M.
  • Journal Title: JBiol Chem. 282 Pages: 33681-33690
  • Peer Reviewed
• [Journal Article] A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. (2007)
  • Author(s): Nangaku M, Izuhara Y, Takizawa S, Yamashita T, Fujii-Kuriyama Y, Ohneda O, Yamamoto M, van Ypersele de Strihou C, Hirayama N, and Miyata T.
  • Journal Title: Arterioscler Thromb Vas Biol. 27 Pages: 2548-2554
  • Peer Reviewed
• [Journal Article] Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. (2007)
  • Author(s): Oshima M, Mimura J, Yamamoto M, and Fujii-Kuriyama Y.
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 276-282
  • Peer Reviewed
• [Journal Article] Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. (2007)
  • Author(s): Okitsu Y, Takahashi S, Minegishi N, Kameoka J, Kaku M, Yamamoto M, Sasaki T, and Harigae H
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 383-387
  • Peer Reviewed
• [Journal Article] Dysfunction of Nrf2 decreases KBrO_3-induced oxidative DNA damage in Oggl-null mice. (2007)
  • Author(s): Jaloszynski P, Murata S, Shinkai Y, Takahashi S, Kumagai Y, Nishimura S, and Yamamoto M.
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 966-971
  • Peer Reviewed
• [Journal Article] Carcinogenesis and transcriptional regulation through Maf recognition elements. (2007)
  • Author(s): Motohashi H, and Yamamoto M.
  • Journal Title: Cancer Sci. 98 Pages: 135-139
  • Peer Reviewed
• [Journal Article] Regulation of GATA1 gene expression. (2007)
  • Author(s): Kobayashi M, and Yamamoto M.
  • Journal Title: J Biochem. 142 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Use of gene manipulated mice in the study of erythropoietin gene expression. (2007)
  • Author(s): Suzuki N, Obara N, and Yamamoto M.
  • Journal Title: Methods Enzymol. 435 Pages: 157-177
  • Peer Reviewed
• [Journal Article] 酸素センシングと赤血球造血シグナル (2007)
  • Author(s): 今川重彦、小原 直、鈴木教郎、山本雅之
  • Journal Title: 細胞 39 Pages: 537-540
  • Peer Reviewed
• [Journal Article] GATA因子スイッチングとGATA-1白血病 (2007)
  • Author(s): 清水律子、山本雅之
  • Journal Title: 生化学 79 Pages: 941-952
  • Peer Reviewed
• [Journal Article] 酸化ストレス防御のための生体内センサー: Keap1-Nrf2制御システム (2007)
  • Author(s): 田口恵子、山本雅之
  • Journal Title: 化学と生物 45 Pages: 857-862
  • Peer Reviewed
• [Journal Article] 食物と酸素由来の環境ストレスを感知するセンサー系 (2007)
  • Author(s): 大辻摩希子、山本雅之
  • Journal Title: 細胞工学 12月号 Pages: 1386-1390
  • Peer Reviewed
• [Presentation] Genetic Analysis of Mouse GATA-related Leukemia and Leukemic Stem Cells. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Gordon Research Conference on Red Cells, Centre Paul Langevin in Aussois.
  • Place of Presentation: Aussois, France
  • Year and Date: 20070520-25
• [Presentation] Functional analyses of GATA-2 with knockdown and conditional knockout mice. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: EMBO WORKSHOP ON The Role and Control of GATA Fact ors in Tissue Development and Disease.
  • Place of Presentation: Capri, Italy
  • Year and Date: 20070414-17
• [Presentation] The environmental response to food and oxygen. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: JST-ERATO Environmental Response Project International Symposium on "The Environmental Response".
  • Place of Presentation: EPOCHAL Tsukuba International Congress Center, Tsukuba
  • Year and Date: 2007-12-21
• [Presentation] Molecular Mechanisms of Adaptive Responses to Food and Oxygen. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The International Conference on Food Factors for Health Promotion (ICOFF2007)
  • Place of Presentation: Kyoto
  • Year and Date: 2007-11-29
• [Presentation] 酸化ストレス応答の分子基盤と疾患 (2007)
  • Author(s): 山本雅之
  • Organizer: CKDと心血管イベントExpert Meeting特別講演
  • Place of Presentation: 東京會舘
  • Year and Date: 2007-11-27
• [Presentation] 親電子性物質・酸化ストレス応答の分子機構 (2007)
  • Author(s): 山本雅之
  • Organizer: 第7回 システム生物医学研究会
  • Place of Presentation: 東京大学先端科学技術研究センター システム生物医学ラボラトリー主催、箱根湯本
  • Year and Date: 2007-11-21
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 東海医学会講演会
  • Place of Presentation: 東海大学
  • Year and Date: 2007-11-13
• [Presentation] The Nrf2-Keap1 Stress Response System. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The 23rd Kumamoto Medical Bioscience Symposium on New Insights into Metabolic Disorders and Vascular Disease.
  • Place of Presentation: Kumamoto
  • Year and Date: 2007-11-12
• [Presentation] GATA因子と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第2回つくば医科学研究交流会ランチョンセミナー
  • Place of Presentation: 三菱化学つくばクリエーションセンター
  • Year and Date: 2007-11-10
• [Presentation] Two-site substrate recognition model for the Keapl-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Distinguished Professor's Seminar.
  • Place of Presentation: University of Arizona, Tucson, USA
  • Year and Date: 2007-11-02
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechani sm. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Adjunct Professor Lecture at Johns Hopkins University Blumberg School of Public Health, Baltimore
  • Place of Presentation: Johns Hopkins University Blumberg School of Public Health, Baltimore, USA
  • Year and Date: 2007-10-31
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: NIEHS Seminar.
  • Place of Presentation: Research Triangle Park(RTP), USA
  • Year and Date: 2007-10-30
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: National University of Singapore-Tohoku University/Centre of Excellence Joint Symposium"Basic and Clinical Research on Signal Transduction Diseases"
  • Place of Presentation: Centre for Life Sciences, National University of Singapore, Singapore, Singapore
  • Year and Date: 2007-09-05
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 臨床研セミナー
  • Place of Presentation: (財)東京都医学研究機構 東京都臨床医学総合研究所
  • Year and Date: 2007-08-10
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The 3^<rd> DECODE for Biological Responses International Meeting.
  • Place of Presentation: Odaiba, Tokyo
  • Year and Date: 2007-08-04
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 第5回フリーラジカルと脳疾患 東日本研究会特別講演
  • Place of Presentation: 経団連会館、大手町
  • Year and Date: 2007-07-28
• [Presentation] 環境応答の分子機構 (2007)
  • Author(s): 山本雅之
  • Organizer: 第5回RCGMフロンティアシンポジウム「ゲノム医学一基礎から未来医療へ」
  • Place of Presentation: 埼玉医科大学日高キャンパス創立30周年記念講堂、日高市
  • Year and Date: 2007-07-27
• [Presentation] GATA転写因子群の機能異常と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第17回 日本産婦人科・新生児血液学会シンポジウム「ダウン症候群と一過性骨髄造血(TAM)」
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2007-06-30
• [Presentation] 細胞の癌化とその抑制における転写因子の役割 (2007)
  • Author(s): 山本雅之
  • Organizer: 文部科学省がん特定領域研究「遺伝情報システム異常と発がん」
  • Place of Presentation: 癌研究会吉田富三記念講堂、有明
  • Year and Date: 2007-06-30
• [Presentation] 親電子性物質・酸化ストレス応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 循環器内科リサーチセミナー
  • Place of Presentation: 東北大学
  • Year and Date: 2007-05-30
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 日本生化学会東北支会シンポジウム
  • Place of Presentation: 艮陵会館、仙台
  • Year and Date: 2007-05-12
• [Presentation] 酸化ストレス応答と呼吸器疾患 (2007)
  • Author(s): 山本雅之
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京フォーラム
  • Year and Date: 2007-05-11
• [Presentation] GATA転写因子群の機能異常と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第50回 東北小児白血病研究会
  • Place of Presentation: かんぽヘルスプラザ仙台
  • Year and Date: 2007-04-28