2009 Fiscal Year Final Research Report
Roles of transcription factors for carcinogenesis and carcinogenesisdefense
Project/Area Number |
17013017
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Tohoku University (2007-2009) University of Tsukuba (2005-2006) |
Principal Investigator |
MASAYUKI Yamamoto Tohoku University, 大学院・医学系研究科, 教授 (50166823)
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Co-Investigator(Kenkyū-buntansha) |
RITSUKO Shimizu 東北大学, 大学院・医学系研究科, 教授 (40226262)
KINUKO Ohneda 高崎健康福祉大学, 薬学部・薬学科, 教授 (50323291)
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Project Period (FY) |
2005 – 2009
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Keywords | 転写因子 / 発癌 / 癌抑制 |
Research Abstract |
In this study, we investigated roles transcription factors play on carcinogenesis and carcinogenesis defense in vivo, focusing on the Nrf2 and GATA transcription factors. We have found that co-operative function of Nrf2 and Keap1, which mediates cellular stress response, is important for the cancer carcinogenesis defense so that the failure in Nrf2-Keap1 system leads to the onset of cancer and poor prognosis. We have further found that deregulated function of GATA factors, which act as key molecules in hematopoietic homeostasis, causes leukemogenesis.
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[Journal Article] Novel regulation of the Nrf2-Keap1 pathway by the selective autophagy substrate p622010
Author(s)
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou Y-S, Ueno I, Sakamoto A, Tong KI, Kim M, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M
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Journal Title
Nature Cell Biol 12
Pages: 213-223
Peer Reviewed
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[Journal Article] Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice2008
Author(s)
Yoh K, Hirayama A, Ishizaki K, Yamada A, Takeuchi M, Yamagishi S, Morito N, Nakano T, Ojima M, Shimohata H, Itoh K, Takahashi S, Yamamoto M
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Journal Title
Genes Cells 13
Pages: 1159-1170
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[Journal Article] Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes2007
Author(s)
Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, Yamamoto M
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Journal Title
Biochem J 404
Pages: 459-466
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[Journal Article] Potential involvement of pathophysiologically formed 8-nitorguanosine 3', 5'-cyclic monophosphate in nitric oxide-induced signal transduction2007
Author(s)
Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T
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Journal Title
Nature Chem Biol 3
Pages: 727-735
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[Journal Article] Loss of p62/SQSTM1 suppresses cytoplasmic inclusion body formation and liver injury in autophagy-deficient mouse2007
Author(s)
Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K
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Journal Title
Cell 131
Pages: 1149-1163
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[Journal Article] Molecular basis distinguishing the DNA binding profile of NRF2-MAF heterodimer from that of MAF homodimer2007
Author(s)
Kimura M, Yamamoto T, Zhang J, Itoh K, Kyo M, Kamiya T, Aburatani H, Katsuoka F, Kurokawa H, Tanaka T, Motohashi H, Yamamoto M
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Journal Title
J Biol Chem 282
Pages: 33681-33690
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[Journal Article] Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions2005
Author(s)
Tauchi M, Hida A, Negishi T, Katsuoka F, Noda S, Mimura J, Hosoya H, Yanaka A, Aburatani H, Fujii-Kuriyama Y, Motohashi H, Yamamoto M
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Journal Title
Mol Cell Biol 25
Pages: 9360-9368
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[Journal Article] Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema2005
Author(s)
Iizuka T, Ishii Y, Itoh K, Kiwamoto T, Kimura T, Matsuno Y, Morishima Y, Hegab AE, Homma S, Nomura A, Sakamoto T, Shimura M, Yoshida A, Yamamoto M, Sekizawa K
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Journal Title
Genes Cells 10
Pages: 1113-1125
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