Isolation and characterization of cancer-related genes in mouse models

2009 Fiscal Year Final Research Report

• Project/Area Number: 17013033
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Niigata University
• Principal Investigator: KOMINAMI Ryo Niigata University, 医歯学系, 教授 (40133615)
• Co-Investigator(Kenkyū-buntansha): MISHIMA Yukio 新潟大学, 医歯学系, 准教授 (30166003) ; HIROSE Satoshi 新潟大学, 医歯学系, 助教 (10415276) ; KATSURAGI Yoshinari 新潟大学, 医歯学系, 助教 (60401759) ; OBATA Miki 新潟大学, 医学部, 教務職員 (00420307) ; INOUE Jun 新潟大学, 医歯学系, 助手 (70323962)
• Project Period (FY): 2005 – 2009
• Keywords: 研究分担者 / Bcl11b遺伝子 / がん抑制遺伝子 / 細胞増殖 / アポトーシス / 機能解析

Research Abstract

Analysis of radiation-induced thymic lymphomas and atrophic thymuses revealed that Bcl11b functions as a suppressor at an early stage of the lymphoma development. Bcl11b transcription factor downregulates Chk1 check point kinase and its targets include cell cycle inhibitors such as p27 kip1 and p57 kip2 and also β-catenin. Deregulation of these proteins in Bcl11b heterozygous mice contributes to development of lymphomas and colon cancers.

Research Products

• [Journal Article] An essential developmental checkpoint for production of the T cell lineage. (2010)
  • Author(s): Ikawa T, Hirose S, Masuda K, Kakugawa K, Satoh R, Shibano-Satoh A, Kominami R, Katsura Y, Kawamoto H.
  • Journal Title: Science 329 Pages: 93-96
  • Peer Reviewed
• [Journal Article] Bclllb heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in y-irradiated mice. (2010)
  • Author(s): Go R, Hirose S, Morita S, Yamamoto T, Katsuragi Y, Mishima Y, Kominami R.
  • Journal Title: Cancer Science 101 Pages: 347-1353
  • Peer Reviewed
• [Journal Article] Clonally expanding thymocytes having lineage capability in y-ray induced mouse atrophic thymus. (2010)
  • Author(s): Yamamoto T, Morita S, Go E, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R.
  • Journal Title: Int.J.Radiation Oncology Biol. 77 Pages: 235-243
  • Peer Reviewed
• [Journal Article] Haploinsufficiency and acquired loss of Bclllb and H2AX induced blast crisis of chronic myelogenous leukemia in a transgenic mouse model. (2009)
  • Author(s): Nagamachi A, Yamasaki N, Miyazaki K, Oda H, Miyazaki M, Honda Z, Kominami R, Inaba T, Honda H.
  • Journal Title: Cancer Science 100 Pages: 1219-1226
  • Peer Reviewed
• [Journal Article] Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. (2009)
  • Author(s): Akulevich N, Saenko V, Rogounovitch T, Drozd V, Lushnikov E, Ivanov V, Mitsutake N, Kominami R, Yamashita S.
  • Journal Title: Endocnine-Related Cancer 16 Pages: 491-503
  • Peer Reviewed
• [Journal Article] Effect of Bclllb genotypes and gamma-radiation on the development of mouse thymic lymphomas. (2008)
  • Author(s): Yoshikai Y, Sato T, Morita S, Kohara Y, Takagi R, Mishima Y, Kominami R.
  • Journal Title: Biochem Biophys Res Commun. 373 Pages: 282-285
  • Peer Reviewed
• [Journal Article] Mtf-1lymphoma-susceptibility locus affects retention of large thymocytes with high ROS levels in mice after γ-irradiation. (2007)
  • Author(s): Maruyama M, Yamamoto T, Kohara Y, Katsuragi Y, Mishima Y, Aoyagi Y, Kominami R.
  • Journal Title: Biochem.Biophys.Res.Commun. 354 Pages: 209-215
  • Peer Reviewed
• [Journal Article] Haploinsufficiency of Bclllb for suppression of lymphomagenesis and thymocyte development. (2007)
  • Author(s): Kamimura K, Ohi H, Kubota T, Okazuka K, Yoshikai Y, Wakabayashi Y, Aoyagi Y, Mishima Y, Kominami R.
  • Journal Title: Biochem.Biophys.Res.Commun. 355 Pages: 538-542
  • Peer Reviewed
• [Journal Article] Multi-step lymphomagenesis deduced from DNA changes in thymic lymphomas and atrophic thymuses at various times after y-irradiation. (2007)
  • Author(s): Ohi H, Mishima Y, Kamimura K, Maruyama M, Sasai K, Kominami R.
  • Journal Title: Oncogene 26 Pages: 5280-5289
  • Peer Reviewed
• [Journal Article] Lack of Bclllb tumor suppressor results in vulnerability to DNA replication stress andd amages. (2007)
  • Author(s): Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R.
  • Journal Title: Oncogene 26 Pages: 5840-5850
  • Peer Reviewed
• [Journal Article] Trp53 affects the developmental anomaly of clefts of the palate in irradiated mouse embryos but not clefts of the lip with or without the palate. (2006)
  • Author(s): Narai S, Kodama Y, Maeda Y, Yokoyama M, Takagi R, Kominami R.
  • Journal Title: Radiation Research 166 Pages: 877-882
  • Peer Reviewed
• [Journal Article] Expression of TCRαβpartly rescues developmental arrest and apoptosis of αβT cells in Bclllb-/-mice. (2006)
  • Author(s): Inoue J, Kanefuji T, Okazuka K, Watanabe H, Mishima Y, Kominami R.
  • Journal Title: J Immunology 176 Pages: 5871-5879
  • Peer Reviewed
• [Journal Article] Radiation carcinogenesis in mouse thymic lymphomas. (2006)
  • Author(s): Kominami R, Niwa O.
  • Journal Title: Cancer Science 97 Pages: 575-581
  • Peer Reviewed
• [Presentation] Dose-dependent effect of zinc finger transcription factor Bcllllb on differentiation of cytotoxic T cells. (2008)
  • Author(s): Ryo Kominami, Satoshi Hirose, Ryota Ishizawa, Yoshinori Katsuragi, Yoshiya Sakuraba, Yoichi Gondo.
  • Organizer: 22^<nd> International Mammalian Genome Conference, Prague
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2008-11-05
• [Book] γ-Ray-Induced Mouse Thymic Lymphomas : Bclllb Inactivation and Prelymphoma Cells. Springer Library of Congress Control Number : 2008937558(Eds, Nakashima et al)(Radiation Health Risk Sciences) (2009)
  • Author(s): R Kominami, H Ohi, K Kamimura, M Maruyama, T Yamamoto, K Takaku, S Morita, R Go, Y Mishima.
  • Total Pages: 232-239