2009 Fiscal Year Final Research Report
Molecular mechanism of leukemogenesis in ATL
| Project/Area Number |
17013046
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
MATSUOKA Masao Kyoto University, ウイルス研究所, 教授 (10244138)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ヒトT細胞白血病ウイルス1型 / 成人T細胞白血病 / ウイルス発がん |
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| Research Abstract |
Analyses of HTLV-1 provirus in ATL cases showed that Tax was not expressed in about 60% of cases. Nonsense mutations in HTLV-1 provirus of ATL cases were found in all viral genes except HBZ gene, and generated by APOBEC3G before integration. In addition, deletion of 5'LTR of HTLV-1 provirus in ATL cases also occurred before integration. These findings suggest significance of HBZ gene in ATL cases. The HBZ gene transcript was found in all ATL cases, and had growth-promoting activity. In HBZ transgenic mice, T-cell lymphomas and inflammatory diseases occurred, indicating that HBZ gene plays a central role in the pathogenesis by HTLV-1.
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