2009 Fiscal Year Final Research Report
Molecular mechanisms controlling spontaneous mutations
| Project/Area Number |
17013060
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
MAKI Hisaji Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (20199649)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 突然変異 / 酸素ラジカル / 活性酸素 / DNA複製 / DNA修復 |
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| Research Abstract |
Studies of spontaneous mutations occurring in E. coli cells grown under a strict anaerobic condition revealed that oxygen radicals are a major cause of spontaneous mutations occurring in aerobically growing cells. In particular, hotspot-type of base substitutions appeared to be caused by oxygen radicals. We also found a mutagenic pathway caused by superoxide and one caused by nucleotide excision repair.
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[Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis.2007
Author(s)
Sakamoto K., Tominaga Y., Yamauchi K., Nakatsu Y., Sakumi K., Yoshiyama K., Egashira A., Kura S., Yao T., Tsuneyoshi M., Maki H., Nakabeppu Y., Tsuzuki, T.
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Journal Title
Cancer Research誌 67巻14号
Pages: 6599-6604
Peer Reviewed
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[Journal Article] Roles of RecA protein in spontaneous mutagenesis in Escherichia coli.2007
Author(s)
Kanie, S., Horibata, K., Kawano, M., Isogawa, A., Sakai, A., Matsuo, N., Nakanishi, M., Hasegawa, K., Yoshiyama, K., Maki, H.
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Journal Title
Genes Genet Systems誌 82巻2号
Pages: 99-108
Peer Reviewed
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[Journal Article] Abnormality in initiation program of DNA replication is monitored by the highly repetitive rDNA array on chromosome XII in budding yeast.2007
Author(s)
Ide, S., Watanabe, K., Watanabe, H., Shirahige, K., Kobayashi, T., Maki, H.
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Journal Title
Mol Cell Biol誌 27巻
Pages: 568-578
Peer Reviewed
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[Journal Article] Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae.2006
Author(s)
Tsubota, T., Tajima, R., Ode, K., Kubota, H., Fukuhara, N., Kawabata, T., Maki, S., Maki, H.
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Journal Title
J Biol Chem誌 281巻
Pages: 32898-32908
Peer Reviewed
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[Journal Article] DNA polymerasesηandκare responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimer in Xenopus laevis oocyte extracts.2005
Author(s)
Yagi, Y., Ogawara, D., Iwai, S., Hanaoka, F., Akiyama, M., Maki, H.
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Journal Title
DNA Repair (Amst)誌 4巻
Pages: 1252-1269
Peer Reviewed
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[Journal Article] RNAi-mediated silencing of OsGEN-L (OsGEN-like), a new member of the RAD2/XPG nuclease family, causes male sterility by defect of microspore development in rice.2005
Author(s)
Moritoh, S., Miki, D., Akiyama, M., Kawahara, M., Izawa, T., Maki, H., Shimamoto, K.
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Journal Title
Plant Cell Physiol誌 46巻
Pages: 699-715
Peer Reviewed
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