2009 Fiscal Year Final Research Report
Role of the RNA-primase GANP in cancer development
| Project/Area Number |
17013069
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kumamoto University |
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Principal Investigator |
SAKAGUCHI Nobuo Kumamoto University, 大学院・生命科学研究部, 教授 (70192086)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 発がん / 老化 / RNA輸送 / 乳癌 / プライマーゼ |
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| Research Abstract |
Antibody response to T cell dependent antigens accompanies somatic hypermutation of immunoglobulin Variable region genes, which needs to be regulated precisely and safely. We studied the role of a molecule named GANP up-regualted in germinal center B cells in the peripheral lymphoid organs. GANP is essential for affinity maturation of the antigen specific B cells. Impairment of GANP function caused lymphomas and mammary gland tumors in mice. We showed that the GANP impairments are associated with tumor development in humans and provided the information regarding spontaneous cancer development during inflammation..
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[Journal Article] Germinal center-associated nuclear protein, a human homologue of SAC3, is necessary for centromere cohesion and sister-chromatid exchange during mitosis.2010
Author(s)
Nobukazu Okamoto, Kazuhiko Kuwahara, Kazutaka Ohta, Masahiro Kitabatake, Hideya Igarashi, Katsumasa Takagi, Hiroshi Mizuta, Eisaku Kondo, Nobuo Sakaguchi
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Journal Title
Genes to Cells 15
Pages: 471-483
Peer Reviewed
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