2009 Fiscal Year Final Research Report
Analysis of role of mitotic regulation and its abnormalities in carcinogenesis
| Project/Area Number |
17013070
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Keio University (2006-2009)
Kumamoto University (2005) |
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Principal Investigator |
SAYA Hideyuki Keio University, 医学部, 教授 (80264282)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 癌 / 遺伝子 / 細胞・組織 / 細胞分裂 / 細胞骨格 / チェックポイント / 細胞運動 / タンパク質分解 |
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| Research Abstract |
Abnormal regulation of G2/M progression induces the drastic phenotypic changes and the genomic instability in cells. The G2/M progression is controlled by two biochemical events, protein degradation and protein phosphorylation. Therefore, regulatory factors of these two biochemical events are considered to play a critical role in development and progression of tumors. Specific aims of our project were i) to analyze molecular mechanisms regulating the transition of G2/M phase, ii) to clarify the role of abnormal regulation of the mitotic molecules and iii) to identify the targets for cancer therapies. As the results, we could elucidate the novel functions of mitotic regulating molecules including Aurora-A, WARTS, Cdh1 and Mklp2 and, furthermore, clarify the molecular mechanism of mitotic catastrophe induced by conventional chemotherapeutic agents.
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[Journal Article] The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010
Author(s)
Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S
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Journal Title
Peer Reviewed
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[Journal Article] K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.2009
Author(s)
Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H, Yamashita Y
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Journal Title
Cancer Res 69
Pages: 3901-3909
Peer Reviewed
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[Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.2007
Author(s)
Kuninaka S, Iida S, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S, Saya H
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Journal Title
Oncogene 26
Pages: 2395-2406
Peer Reviewed
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[Journal Article] The tumor suppressor WARTS activates the Omi/HtrA2-dependent pathway of cell death.2005
Author(s)
Kuninaka S, Nomura M, Hirota T, Iida S, Hara T, Honda S, Kunitoku N, Sasayama T, Arima Y, Marumoto T, Koja K, Yonehara S, Saya H
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Journal Title
Oncogene 24
Pages: 5287-5298
Peer Reviewed
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