2009 Fiscal Year Final Research Report
Cancer development induced by deregulation of nuclear factors
| Project/Area Number |
17013071
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kumamoto University |
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Principal Investigator |
NAKAO Mitsuyoshi Kumamoto University, 発生医学研究所, 教授 (00217663)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 癌 / DNA メチル化 / クロマチン / 細胞核 |
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| Research Abstract |
This study focused on investigating the molecular basis of epigenetic cell deregulation in cancer, through analyzing the abnormalities of nuclear factors including methylated DNA binding protein MBD1 and its associated factor MCAF1, CTCF-mediated chromatin insulator, HMGA proteins, SUMOylation of nuclear proteins, and nuclear substructure. These findings strongly contribute to promoting cancer diagnosis and therapy.
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Research Products
(34 results)
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[Journal Article] Cohesin mediates transcriptional insulation by CCCTC-binding factor.2008
Author(s)
K.S. Wendt, K. Yoshida, T. Itoh, M. Bando, B. Koch, E. Schirghuber, S. Tsutsumi, G. Nagae, K. Ishihara, T. Mishiro, K. Yahata, F. Imamoto, H. Aburatani, M. Nakao, N. Imamoto, K. Maeshima, K. Shirahige, J.M. Peters
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Journal Title
Nature 451
Pages: 796-803
Peer Reviewed
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[Journal Article] Inhibition of DNA binding of Sox2 by the SUMO conjugation.2006
Author(s)
S. Tsuruzoe, K. Ishihara, Yasuhiro Uchimura, S. Watanabe, Y. Sekita, T. Aoto, H. Saitoh, Y. Yuasa, H. Niwa, M. Kawasuji, H. Baba, M. Nakao
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Journal Title
Biochem. Biophys. Res. Commun. 351
Pages: 920-926
Peer Reviewed
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