2009 Fiscal Year Final Research Report
Role of DNA methylation and altered histone modification in development and progression of cancer
Project/Area Number |
17013073
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Sapporo Medical University |
Principal Investigator |
TOYOTA Minoru Sapporo Medical University, 医学部, 教授 (70270676)
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Project Period (FY) |
2005 – 2009
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Keywords | エピジェネティクス / メチル化 / ヒストン / 遺伝子発現 / クロマチン |
Research Abstract |
Numerous evidences have suggested that DNA methylation and histone modification play a role in tumorigenesis. However, information about target of epigenetic alterations is not enough. Here, we performed genome wide microarray analysis to identify novel targets of DNA methylation. DNA methylation can also be useful to predict sensitivity of tumors to anti-cancer drugs. We also found that histone H3K4 methylation can be a good molecular marker to identify non-coding RNA silenced by epigenetic changes in cancer.
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[Journal Article] IGFBP7 is p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
Author(s)
Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JPJ, Shinomura Y, Tokino T, Toyota M.
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Journal Title
Carcinogenesis 31
Pages: 342-349
Peer Reviewed
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[Journal Article] Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma.2009
Author(s)
Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
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Journal Title
Clin Cancer Res 15
Pages: 4356-4364
Peer Reviewed
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[Journal Article] Overexpression of Aurora a by loss of CHFR gene expresion increases the growth of HTLV-1-infected T cells through enhanced NF-kB activity.2009
Author(s)
Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara J, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
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Journal Title
Int J Cancer 124
Pages: 2607-2615
Peer Reviewed
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[Journal Article] Sensitive and specific detection of early gastric cancer using DNA methylation analysis of gastric washing.2009
Author(s)
Watanabe, Y, Kim, HS, Castoro, RJ, Chyng, W, Estecio, MR, Kondo, K, Guo, Y, Ahmed, SS, Toyota, M, Itoh, F, Suk, KT, Cho, MY, Shen, L, Jelinek, J, Issa, JP.
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Journal Title
Gastroenterol 136
Pages: 2149-2158
Peer Reviewed
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[Journal Article] a potent tumor suppressor2009
Author(s)
Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y,, Tokino T. CHFR
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Journal Title
downregulates interleukin-8 via inhibition of NF-κB. Oncogene 28
Pages: 2643-2653
Peer Reviewed
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[Journal Article] Elevated Dnmt3a activity promotes polyposis in ApcMin mice by relaxing extracellular restrains on Wnt signaling.2009
Author(s)
Samuel MS, Suzuki H, Buchert M, Putoczki TL, Tebbutt NC, Lundgren-May T, Christou A, Inglese M, Toyota M, Heath JK, Ward RL, Waring PM, Ernst M
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Journal Title
Gastroenterol 137
Pages: 902-913
Peer Reviewed
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[Journal Article] Characteristic epigenetic profiles of malignant pleural mesothelioma.2009
Author(s)
Goto Y, Shinjo K, Kondo Y, Shen L, Toyota M, Suzuki H, Gao Y, An B, Fujii M, Murakami H, Osada H, Taniguchi T, Usami N, Kondo M, Hasegawa Y, Shimokata K, Matsuo K, Hida T, Fujimoto N, Kishimoto T, Issa JP, Sekido Y
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Journal Title
Cancer Res 69
Pages: 9073-9082
Peer Reviewed
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[Journal Article] dentification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members.2008
Author(s)
Sasaki Y, Ohshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
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Journal Title
ol Cancer Res 6
Pages: 395-406
Peer Reviewed
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[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
Author(s)
Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka Y, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
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Journal Title
Carcinogenesis 29
Pages: 1312-1318
Peer Reviewed
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[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008
Author(s)
Yamamoto E, Toyota M, Suzuki H, Kondo Y, Imai K, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
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Journal Title
Cancer Epidemiol Biomarkers Prev 2555-2564
Pages: 2555-2564
Peer Reviewed
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[Journal Article] Integrated genetic and epigenetic analysis identifies colon cancer corresponding to three different subclasses of disease.2007
Author(s)
Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, Hernandez N, Chen X, Ahmed S, Konishi K, Hamilton SR, Issa JPJ
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Journal Title
Proc Natl Acad Sci U S A 104
Peer Reviewed
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[Journal Article] Gene amplification and overexpression of PRDM14 in breast cancer2007
Author(s)
Nishikawa N, Toyota M, Suzuki H, Homma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
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Journal Title
Cancer Res 67
Pages: 9649-9657
Peer Reviewed
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[Journal Article] Comparing the DNA hypermethylation with gene mutations in human colorectal cancer.2007
Author(s)
Schuebel KE, Chen E, Cope Lm Glockner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engel, M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB
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Journal Title
Plos Genet 3
Pages: 1709-1723
Peer Reviewed
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[Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
Author(s)
Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
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Journal Title
Cancer Sci 98
Pages: 88-95
Peer Reviewed
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[Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007
Author(s)
Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
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Journal Title
Oncogene 26
Pages: 4699-4713
Peer Reviewed
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[Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007
Author(s)
Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Itoh F, Tokino T
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Journal Title
Clin Cancer Res 13
Pages: 4786-4794
Peer Reviewed
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[Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007
Author(s)
Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
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Journal Title
Carcinogenesis 28
Pages: 2459-2466
Peer Reviewed
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[Journal Article] Antitumor effect of adenoviras-mediated p53 family gene transfer on osteosarcoma cell lines.2007
Author(s)
Ohshima Y, Sasaki Y, Negishi H, Idogawa M, Toyota M, Yamashita T, Wada T, Nagoya S, Kawaguchi S, Yamashita T, Tokino T
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Journal Title
ncer Biol Ther 6
Pages: 1058-1066
Peer Reviewed
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[Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus.2006
Author(s)
Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
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Journal Title
Cancer 106
Pages: 1467-1479
Peer Reviewed
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[Journal Article] Comparative genome analysis identified the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006
Author(s)
aruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
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Journal Title
Cancer Res 66
Pages: 4574-4583
Peer Reviewed
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[Journal Article] Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.2005
Author(s)
Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K
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Journal Title
J Gastroenterol 40
Pages: 504-510
Peer Reviewed
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