2009 Fiscal Year Final Research Report
Molecular mechanism for faithful chromosome segregation
| Project/Area Number |
17013084
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
FUKAGAWA Tatsuo National Institute of Genetics, 分子遺伝研究系, 教授 (60321600)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 癌 / ゲノム / 遺伝学 |
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| Research Abstract |
Faithful chromosome segregation during mitosis is essential for the accurate transmission of genetic material. To facilitate this, each replicated sister chromatid assembles a kinetochore on centromeric DNA which forms a dynamic interface with microtubules from the mitotic spindle. Dysfunction of the kinetochore leads cancer. However, molecular mechanism by which the kinetochore is formed, is still unclear. In this study, we have identified more than 20 molecules, which localize to the kinetochore and characterized each molecule.
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