2009 Fiscal Year Final Research Report
Study on the regulatory mechanism of p53 transactivation by clathrin heavy chain
| Project/Area Number |
17013088
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
ENARI Masato National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所生物学部, 室長 (90294058)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 癌 / 放射線 |
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| Research Abstract |
We have previously identified clathrin heavy chain as a p53-binding protein. In this study, CHC is present in nuclei and promotes p53 transactivation through the enhancement of the interaction between p53 and p300, histone acetyltransferase. We also identified nuclear mitotic apparatus (NuMA)as a nuclear CHC-binding factor and showed that NuMA was a critical determinant for p53-transcriptional selectivity mediated by Cdk8. Moreover, the structural model of CHC-p53 interaction was constructed and an amino acid residue in CHC, which is important for p53 transactivation, was identified. Plasma membrane-associated p53 is involved in the regulation of CHC-dependent endocytosis and actin-mediated cell motility.
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[Journal Article] Oncogene2008
Author(s)
Ohmori K, Endo Y, Yoshida Y, Ohata H, Taya Y, Enari M
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Journal Title
Monomeric but not trimeric clathrin heavy chain regulatesp53-mediated transcription. 27
Pages: 2215-2227
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[Journal Article] CIP2A inhibits PP2A in human malignancies2007
Author(s)
Jnttila MR, Puustinen P, Niemela M, Ahola R, Arnold H, Bottzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grenman R, Kast J, Kallunki T, Sears R, Kahari VM, Westermarck J.
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Journal Title
Cell 130
Pages: 2083-2093
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[Journal Article] Differential roles of ATM-and Chk2-mediated phosphorylation of Hdmx iresponse to DNA damage.2006
Author(s)
Pereg Y, Lam S, Teunisse A, Biton S, Meulmeester E, Mittelman L, Buscemi G, Okamoto K, Taya Y, Shiloh Y, Jochemsen AG
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Journal Title
Mol. Cell. Biol. 26
Pages: 6819-6831
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[Journal Article] DNA damage-Induced phosphorylation of MdmX at Serine-367 activates p53 by targeting MdmX for Mdm2-dependent degradation.2005
Author(s)
Okamoto K, Kashima K, Pereg Y, Ishida, M, Yamazaki S, Nota A, Teunisse A, Migliorini D, Kitabayashi I, Marine JC, Prives C, Shiloh Y, Jochemsen AG, Taya Y
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Journal Title
Mol. Cell. Biol. 25
Pages: 9608-9620
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[Journal Article] p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.2005
Author(s)
Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A
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