2009 Fiscal Year Final Research Report
Identification and characterization of p53-target genes
| Project/Area Number |
17013089
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
ARAKAWA Hirofumi National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 生物物理部, 部長 (70313088)
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| Project Period (FY) |
2005 – 2009
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| Keywords | p53 / 転写 / 標的遺伝子 / がん / マイクロアレイ |
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| Research Abstract |
In the present study, we identified and characterized seven novel p53-target genes ; DFNA5, SEMA3F, BLNK, UNC5A, TMPS, NEEP21 and Mieap. DFNA5, UNC5A, TMPS and NEEP21 are involved in p53-dependent apoptosis. SEMA3F is a mediator of p53-regulated anti-angiogenesis. Discovery of these genes could provide more information to two major functions of p53 ; cell death and anti-angiogenesis. On the other hand, discovery of BLNK and Mieap demonstrates that there are very novel pathways for p53 tumor suppression. BLNK prevents aneuploidy by inhibiting cytokinesis after DNA damage, leading to maintenance of genomic stability. Moreover, Mieap plays an essential role in mitochondrial quality control. These findings could not only shed light on the mechanism of p53 tumor suppression but also contribute to understanding of cancer nature.
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[Journal Article] Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.2007
Author(s)
Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chretien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rotig A.
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Journal Title
Nat Genet 39
Pages: 776-780
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[Journal Article] The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage.2006
Author(s)
Masuda Y, Futamura M, Kamino H, Nakamura Y, Kitamura N, Ohnishi S, Miyamoto Y, Ichikawa H, Ohta T, Ohki M, Kiyono T, Egami H, Baba H, Arakawa H.
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Journal Title
J Hum Genet 51
Pages: 652-664
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[Journal Article] Identification of NEEP21, encoding neuron-enriched endosomal protein of 21 kDa, as a transcriptional target of tumor suppressor p53.
Author(s)
Ohnishi S, Futamura M, Kamino H, Nakamura Y, Kitamura N, Miyamoto Y, Miyamoto T, Shinogi D, Goda O, Arakawa H.
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Journal Title
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