Regulation of cell proliferation and cell death by stress signaling in cancer

2009 Fiscal Year Final Research Report

• Project/Area Number: 17014013
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: ICHIJO Hidenori The University of Tokyo, 大学院・薬学系研究科, 教授 (00242206)
• Project Period (FY): 2005 – 2009
• Keywords: ASK1 / ASK2 / MAPキナーゼ / アポトーシス / ASKファミリー

Research Abstract

This study aimed at analyzing the mechanisms by which cancer cells acquire abnormal proliferation and death-resistant phenotypes in the context of perturbation of stress signaling. By using ASK family knockout mice, we found that stress-activated MAP kinases play pivotal roles in development and expansion of human cancer.

Research Products

• [Journal Article] Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. (2010)
  • Author(s): Seong, H.A., Jung, H., Ichijo, H., Ha, H.
  • Journal Title: J. Biol. Chem. 285 Pages: 2397-2414
• [Journal Article] Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. (2009)
  • Author(s): Cekic, C., Casella, C.R., Eaves, C.A., Matsuzawa, A., Ichijo, H., d Mitchell, T.C.
  • Journal Title: J. Biol. Chem. 284 Pages: 31982-31991
• [Journal Article] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. (2009)
  • Author(s): Nagai, H,, Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A., Ichijo, H.
  • Journal Title: Mol. Cell 36 Pages: 805-818
• [Journal Article] TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. (2009)
  • Author(s): Kundu M, Pathak SK, Kumawat K, Basu S, Chatterjee G, Pathak S, Noguchi T, Takeda K, Ichijo, H, Thien CB, Langdon WY, Basu J. A
  • Journal Title: Nat. Immunol. 10 Pages: 918-926
• [Journal Article] Mitochondrial Phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. (2009)
  • Author(s): Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., Ichijo, H.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 106 Pages: 12301-12305
• [Journal Article] Serine 58 of 14-3-3{zeta} is a molecular switch regulating ASK1 and oxidant stress-induced cell death. (2009)
  • Author(s): Zhou, J., Shao, Z., Kerkela, R., Ichijo, H., Muslin, A., Pombo, C., Force, T.
  • Journal Title: Mol. Cell. Biol. 29 Pages: 4167-4176
• [Journal Article] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. (2009)
  • Author(s): Waak, J., Weber, S.S., Gorner, K., Schall, C., Ichijo, H., Stehle, T., Kahle, P.J.
  • Journal Title: J. Biol. Chem. 284 Pages: 14245-14257
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. (2009)
  • Author(s): Iriyama, T., Takeda, K., Nakamura, H.,Morimoto, Y., Kuroiwa, T., Mizukami, J.,Umeda, T., Noguchi, T., Naguro, I.,Nishitoh, H., Saegusa, K., Tobiume, K.,Homma, T., Shimada, Y., Tsuda, H., Aiko, S.,Imoto, I., Inazawa, J., Chida, K., Kamei, Y.,Kozuma, S., Taketani, Y., Matsuzawa, A., Ichijo, H.
  • Journal Title: EMBO J. 28 Pages: 843-853
• [Journal Article] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. (2008)
  • Author(s): Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., Ichijo, H.
  • Journal Title: Genes Dev. 22 Pages: 1451-1464
• [Journal Article] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage. (2008)
  • Author(s): Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K., Ichijo, H.
  • Journal Title: J. Biol. Chem. 283 Pages: 7657-7665
• [Journal Article] Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. (2007)
  • Author(s): Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K., Ichijo, H.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 8152-8163
• [Journal Article] ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds. (2007)
  • Author(s): Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K., Ichijo, H.
  • Journal Title: J. Cell Biol. 176 Pages: 903-909
• [Journal Article] Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1. (2007)
  • Author(s): Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A., Ichijo, H.
  • Journal Title: J. Biol. Chem. 282 Pages: 7522-7531
• [Journal Article] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. (2006)
  • Author(s): Kitagawa, D., Kajiho, H., Negishi, T., Ura, S., Watanabe, T., Wada, T., Ichijo, H., Katada, T., Nishina, H.
  • Journal Title: Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. EMBO J. 25 Pages: 3286-3297
• [Journal Article] Apoptosis- regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. (2006)
  • Author(s): Chiang, E., Dang, O., Anderson, K., Matsuzawa, A., Ichijo, H., David, M.
  • Journal Title: J. Immunol. 176 Pages: 5720-5724
• [Journal Article] Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. (2006)
  • Author(s): Liu, Q., Wilkins, B.J., Lee, Y.J., Ichijo, H., Molkentin, J.D.
  • Journal Title: Mol. Cell. Biol. 26 Pages: 3785-3797
• [Journal Article] Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death. (2005)
  • Author(s): Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J., Ichijo, H.
  • Journal Title: J. Biol. Chem. 280 Pages: 37033-37040
• [Journal Article] Interaction of DJ-1 with Daxx inhibits ASK1 activity and cell death. (2005)
  • Author(s): Junn, E., Taniguchi, H., Jeong, B.S., Zhao, X., Ichijo, H., Mouradian, M., M.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 102 Pages: 9691-9696
• [Journal Article] ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. (2005)
  • Author(s): Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., Ichijo, H.
  • Journal Title: ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. Nature Immunol. 6 Pages: 587-592
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
  • Author(s): Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H., Ichijo, H.
  • Journal Title: EMBO J. (in press)
• [Presentation] ASK family kinases in stress response and disease (2007)
  • Author(s): Hidenori Ichijo
  • Organizer: The 55th Fall Conference of The Korean Association of Immunobiologists
  • Place of Presentation: Korea
  • Year and Date: 20071108-20071109
• [Presentation] ASK family proteins in stress-induced apoptosis and disease (2007)
  • Author(s): Hidenori Ichijo
  • Organizer: FASEB Summer Research Conferences - From unfolded proteins in the endoplasmic reticulum to disease
  • Place of Presentation: USA
  • Year and Date: 20070728-20070802
• [Presentation] ASK family proteins in stress response and disease (2007)
  • Author(s): Hidenori Ichijo
  • Organizer: The International Conference on Free Radicals in Biosystems
  • Place of Presentation: Kuwait
  • Year and Date: 20070318-20070321
• [Presentation] ASK family proteins in stress response and disease (2006)
  • Author(s): Hidrnoi Ichijo
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Year and Date: 20060525-20060526
• [Presentation] ASK family proteins in stress response and disease (2006)
  • Author(s): Hidenori Ichijo
  • Organizer: 63rd KSBMB Annual Meeting in 2006
  • Place of Presentation: Korea
  • Year and Date: 2006-05-25
• [Presentation] Redox controls of ASK1-MAP kinase signaling pathway in apoptosis and immunity (2005)
  • Author(s): Hidenori Ichijo
  • Place of Presentation: Italy
  • Year and Date: 2005-09-09