2009 Fiscal Year Final Research Report
Migration of cancer cells and its regulatory mechanism
| Project/Area Number |
17014018
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kobe University (2007-2009)
The University of Tokyo (2005-2006) |
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Principal Investigator |
TAKENAWA Tadaomi Kobe University, 大学院・医学研究科, 特命教授 (40101315)
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| Co-Investigator(Kenkyū-buntansha) |
SUETSUGU Shiro 東京大学, 分子細胞生物学研究所, 講師 (70345031)
IJUIN Takeshi 神戸大学, 大学院・医学研究科, 助教 (00361626)
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| Co-Investigator(Renkei-kenkyūsha) |
IJUIN Takeshi 神戸大学, 大学院・医学研究科, 助教 (00361626)
YAMAZAKI Daisuke 神戸大学, 大学院・医学研究科, 助教 (50422415)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 癌 / 細胞運動 / シグナル伝達 / 葉状仮足 |
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| Research Abstract |
WASP/WAVE, which induces actin polymerization is activated at the leading edge and forms lamellipodia, which generates driving force and then induces invasion and metastasis of cancer cells. Under 3 dimensional culture, elongated mesenchymal cells move with protrusion, which is dependent on Rac-WAVE system. In contrast, round amoeba like cells move with blebbing without protrusion, which is dependent on Rho-actomyosin system. Fer is an oncogene which has tyrosinekinase activity. Fer has lipid binding domain, F-Bar and FX domain and tyrosine kinase domain. F-Bar and FX domain bind to PA and its binding activates tyrosine kinase and induces the phosphorylation of Cortactin and Vav2, resulting in lamellipodia formation and invasion.
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[Journal Article] The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death.2010
Author(s)
Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
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Journal Title
Nature. 465
Pages: 497-501
Peer Reviewed
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[Journal Article] Casein Kinase 2 Interacting Protein-1, a Novel Akt Pleckstrin Homology Domain-Interacting Protein, Down-regulates PI3K/Akt Signaling and Suppresses Tumor Growth In vivo.2007
Author(s)
Tokuda E, Fujita N, Oh-Hara T, Sato S, Kurata A, Katayama R, Itoh T., Takenawa T, Miyazono K, Tsuruo T.
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Journal Title
Cancer Res. 67
Pages: 9666-9676
Peer Reviewed
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[Journal Article] Synaptopodin Protects Against Proteinuria by Disrupting Cdc42:IRSp53:Mena Signaling Complexes in Kidney Podocytes.2007
Author(s)
Yanagida-Asanuma E, Asanuma K, Kim K, Donnelly M, Young Choi H, Hyung Chang J, Suetsugu S, Tomino Y, Takenawa T, Faul C, Mundel P.
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Journal Title
Am.J.Pathol. 171
Pages: 415-427
Peer Reviewed
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[Journal Article] Curved EFC/F-Bar domein dimmers are jointed end to end into a filasment for membrane invagination in endocytosis.2007
Author(s)
Shimada A, Niwa H, Tsujita K, Suetsugu S, Nitta K, Hanawa-Suetsugu K, Azkasaka R, Nishino Y, Toyama M, Chen L, Sugano S, Shirouzu M, Nagayama K, ^*Takenawa T, ^*Yokoyama S.(Correspondent author)
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Journal Title
Peer Reviewed
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[Journal Article] Molecular mechanisms of invadopodium formation : the role of the N-WASP-Arp2/3 complex pathway and cofilin.2005
Author(s)
Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, Condeelis J.
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Journal Title
J.Cell Biol. 168
Pages: 441-452
Peer Reviewed
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[Remarks] ホームページ等
