2009 Fiscal Year Final Research Report
Tumor-stroma interaction mediated by proteases
| Project/Area Number |
17014019
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SEIKI Motoharu The University of Tokyo, 医科学研究所, 教授 (10154634)
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| Co-Investigator(Kenkyū-buntansha) |
KOSIKAWA Naohiko 東京大学, 医科学研究所, 講師 (70334282)
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Isamu (40323638)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 膜型プロテアーゼ / 腫瘍微小環境 / 浸潤 / MT1-MMP |
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| Research Abstract |
MT1-MMP is an integral membrane protease that acts as an important component of cellular machinery promoting invasion and tumor growth. It is also a potent modulator of tumor microenvironment. In this study, we identified substrates of MT1-MMP, analyzed regulation of the proteolytic events, surveyed proteins that bind MT1-MMP, and studied non-protease activity of MT1-MMP. We also validated the potential therapeutic value of MT1-MMP as a molecule target for development of therapeutic strategies.
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Research Products
(30 results)
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[Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.2007
Author(s)
Taniwaki, K., H.Fukamachi, K.Komori, Y.Ohtake, T.Nonaka, T.Sakamoto, T.Shiomi, Y.Okada, T.Itoh, S.Itohara, M.Seiki, I.Yana.
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Journal Title
Cancer Res 67
Pages: 4311-4319
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[Journal Article] Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells.2007
Author(s)
Yana, I., H.Sagara, S.Takaki, K.Takatsu, K.Nakamura, K. Nakao, M.Katsuki, S.Taniguchi, T.Aoki, H.Sato, S.J.Weiss, M.Seiki.
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Journal Title
J Cell Sci 120
Pages: 1607-1614
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[Journal Article] Jr.Matrix metalloproteinase expression and function during fin regeneration in zebrafish : analysis of MT1-MMP, MMP2 and TIMP2.2005
Author(s)
Bai, S., R.Thummel, A.R.Godwin, H.Nagase, Y.Itoh, L.Li, R.Evans, J.McDermott, M.Seiki, M.P.Sarras
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Journal Title
Matrix Biol 24
Pages: 247-260
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