2009 Fiscal Year Final Research Report
Regulation of cell proliferation by receptor tyrosine kinase
| Project/Area Number |
17014039
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nagoya University |
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Principal Investigator |
TAKAHASHI Masahide Nagoya University, 大学院・医学系研究科, 教授 (40183446)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 受容体型チロシンキナーゼ / RETチロシンキナーゼ / シグナル伝達 / 細胞増殖 / 細胞運動 / CD109 / Akt / Girdin |
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| Research Abstract |
Point mutations and structural alterations of receptor tyrosine kinase genes cause cancer and developmental abnormalities. Mutations of the RET tyrosine kinase gene is responsible for the development of multiple endocrine neoplasia type 2 and Hirschsprung's disease. The mutations result in RET activation and inactivation by various mechanisms. In this study, we elucidated the roles of each downstream signaling of RET in cancer cell growth, invasion and metastasis using RET-expressing cancer cell lines and transgenic mice.
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