2009 Fiscal Year Final Research Report
Regulation of cell attachment and motility by Src-mediated signal pathways.
| Project/Area Number |
17014040
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nagoya University |
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Principal Investigator |
HAMAGUCHI Michinari Nagoya University, 大学院・医学系研究科, 総長 (90135351)
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| Co-Investigator(Kenkyū-buntansha) |
SENGA Takeshi 名古屋大学, 大学院・医学系研究科, 准教授 (80419431)
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| Project Period (FY) |
2005 – 2009
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| Keywords | Src / FAK / MMP / invasion / cytokine / nitric oxide |
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| Research Abstract |
The Src kinase is often activated in breast cancer and colon cancer. We have been investigating the mechanisms of how Src kinase activates MMP secretion and enhances cell invasion. We have found cytokines such as TNFalpha and IL-1beta activated Src and FAK, which was required for the stimulation of MMP-9 secretion and cell invasion. We also found that nitric oxide induced cell invasion, which was dependent on the activation of FAK and Src by S-nitrosylation.
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[Journal Article] The cysteine-cluster motif of c-Yes, Lyn and FAK as a suppressive module for the kinases2008
Author(s)
Rahman MA, Senga T, Oo ML, Hasegawa H, Biswas MH, Mon NN, Huang P, Ito S, Yamamoto T, Hamaguchi M.
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Journal Title
Oncol Rep. 19(4)
Pages: 975-80
Peer Reviewed
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[Journal Article] SIRPalpha1 and SIRPalpha2: their role as tumor suppressors in breast carcinoma cells2007
Author(s)
Yamasaki Y, Ito S, Tsunoda N, Kokuryo T, Hara K, Senga T, Kannagi R, Yamamoto T, Oda K, Nagino M, Nimura Y, Hamaguchi M.
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Journal Title
Biochem Biophys Res Commun. 361(1)
Pages: 7-13
Peer Reviewed
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