Cross talk between bone microenvironment and metastatic cancer cell

2009 Fiscal Year Final Research Report

• Project/Area Number: 17014058
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: YONEDA Toshiyuki Osaka University, 大学院・歯学研究科, 教授 (80142313)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Riko 大阪大学, 大学院・歯学研究科, 准教授 (60294112)
• Project Period (FY): 2005 – 2009
• Keywords: 癌 / 骨 / 破骨細胞 / 骨芽細胞 / クロストーク / サイトカイン / 増殖因子 / 疼痛

Research Abstract

Along with increasing of breast and prostate cancer patients, the metastases of cancer into bone has been important issues. It is, therefore, necessary to establish effective solutions for the metastases. Bone resorption and bone formation are active in bone tissues where several types of cells, including immune cells, hematopoietic cells, adipocytes and neural cells, are present. In this study, we examined cross-talk between cancer and bone tissues at molecular level, cell level, and in vivo. Furthermore, we revealed the mechanisms of bone pain associated with bone metastases.

Research Products

• [Journal Article] Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, with causing no osteonecrosis of the jaw in mice. (2010)
  • Author(s): Kobayashi Y, Hiraga T, Ueda A, Wang L, Matsumoto-Nakano M, Hata K, Yatani H, Yoneda T.
  • Journal Title: J Bone Miner Metab 28 Pages: 165-175
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Yoneda T, Hagino H, Sugimoto T, Ota H, Takahashi S, Soen S, Taguchi A, Toyosawa S, Nagata T, Urade M.
  • Journal Title: J Bone Miner Res (印刷中)
  • Peer Reviewed
• [Journal Article] A novel approach for treatment of tumor-Induced bone diseases: Utilizing bisphosphonate derivatives of nucleoside anti-metabolites. (2010)
  • Author(s): Reinholz MM, Zinnen SP, Dueck AC, DingliD, Reinholz GR, Leslie A. Jonart LA,Kitzmann KA, Bruzek AK, Negron V, AbdullaA, Arendt BK, Croatt A, Sanchez-Perez L,Sebesta DP, Lonnberg H, Yoneda T, Nath KA,Jelinek DF, Russell SJ, Ingle JN, SpelsbergTC, Dixon H, Karpeisky A, Lingle WL.
  • Journal Title: Bone (印刷中)
  • Peer Reviewed
• [Journal Article] Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. (2008)
  • Author(s): Tamura D, Hiraga T, Myoui A, Yoshikawa H, Yoneda T.
  • Journal Title: Int J Oncol 33 Pages: 17-24
  • Peer Reviewed
• [Journal Article] Involvement of cell-cell and cell-matrix interactions in bone destruction induced by metastatic MDA-MB-231 human breast cancer cells in nude mice. (2008)
  • Author(s): Nakamura H, Hiraga T, Ninomiya T, Hosoya A, Fujisaki N, Yoneda T, Ozawa H.
  • Journal Title: J Bone Miner Metab 26 Pages: 642-647
  • Peer Reviewed
• [Journal Article] Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype. (2008)
  • Author(s): Oxmann D, Held-Feindt J, Stark AM, Hattermann K, Yoneda T, Mentlein R.
  • Journal Title: Oncogene 27 Pages: 3567-3575
  • Peer Reviewed
• [Journal Article] Breast cancer-derived dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases. (2008)
  • Author(s): Bu G, Lu W, Liu C-C, Selander K, Yoneda T, Hall C, Keller ET, Li Y.
  • Journal Title: Int J Cancer 123 Pages: 1034-1042
  • Peer Reviewed
• [Journal Article] Differential expression of matrix metalloproteinases in brain- and bone-seeking clones of metastatic MDA-MB-231 breast cancer cells. (2007)
  • Author(s): Stark AM, Palmieri D, Meltzer PS, Walker RT, Mentlein R, Yoneda T, Mehdorn HM, Steeg PS, Held-Feindt J.
  • Journal Title: J Neurooncol 81 Pages: 39-48
  • Peer Reviewed
• [Journal Article] Acidic microenvironment created by osteoclasts causes bone pain associated with tumor colonization. (2007)
  • Author(s): Nagae M, Hiraga T, Yoneda T.
  • Journal Title: J Bone Miner Metab 25 Pages: 99-104
  • Peer Reviewed
• [Journal Article] Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. (2007)
  • Author(s): Palmieri D, Bronder JL, Herring JM, Yoneda T, Weil RJ, Stark AM, Kurek R, Vega-Valle E, Feigenbaum L, Halverson D, Vortmeyer AO, Steinberg SM, Aldape K, Steeg PS.
  • Journal Title: Cancer Res 67 Pages: 4190-4198
  • Peer Reviewed
• [Journal Article] NAD(P)H oxidases regulate HIF-2αprotein expression. (2007)
  • Author(s): Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE.
  • Journal Title: J Biol Chem 282 Pages: 8019-8026
  • Peer Reviewed
• [Journal Article] Hypoxia and HIF-1 expression enhance osteolytic bone metastases of breast cancer. (2007)
  • Author(s): Hiraga T, Kizaka-Kondoh S, Hirota K, Yoneda T.
  • Journal Title: Cancer Res 67 Pages: 4157-4163
  • Peer Reviewed
• [Journal Article] The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells. (2007)
  • Author(s): Schmid BC, Rezniczek GA, Fabjani G, Yoneda T, Leodolter S, Zeillinger R.
  • Journal Title: Breast Can Res Treat 106 Pages: 333-342
  • Peer Reviewed
• [Journal Article] Cancer in bone. (2007)
  • Author(s): Yoneda T
  • Journal Title: Oral Science International 5 Pages: 63-72
  • Peer Reviewed
• [Journal Article] Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factorβenhances bone metastases in breast cancer. (2006)
  • Author(s): Hiraga T, Myoui A, Choi ME, Yoshikawa H, Yoneda T.
  • Journal Title: Cancer Res 66 Pages: 2067-2073
  • Peer Reviewed
• [Journal Article] Osteoclasts play a part in pain due to the inflammation adjacent to bone. (2006)
  • Author(s): Nagae M, Hiraga T, Wakabayashi H, Wang L, Iwata K, Yoneda T.
  • Journal Title: Bone 39 Pages: 1107-1115
  • Peer Reviewed
• [Journal Article] A c-Fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. (2006)
  • Author(s): Ohno H, Kubo K, Murooka H, Kobayashi Y, Nishitoba T, Shibuya M, Yoneda T, Isoe T.
  • Journal Title: Mol Cancer Ther 5 Pages: 2634-2643
  • Peer Reviewed
• [Journal Article] Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. (2006)
  • Author(s): Bowden ET, Onikoyi E, Slack R, Myoui A, Yoneda T, Yamada KM, Mueller SC.
  • Journal Title: Exp Cell Res 312 Pages: 1240-1253
  • Peer Reviewed
• [Journal Article] In vivo MRI of cancer cell fate at the single cell level in a mouse model of breast cancer metastasis to the brain. (2006)
  • Author(s): Heyn C, Ronald JA, Ramadan SS, Snir JA, Barry AM, MacKenzie LT, Mikulis DJ, Palmieri D, Bronder JL, Steeg PS, Yoneda T, MacDonald IC, Chambers AF, Rutt BK, Foster PJ.
  • Journal Title: Magnetic Resonance Med 56 Pages: 1001-1010
  • Peer Reviewed
• [Journal Article] Crosstalk between cancer cells and bone microenvironment in bone metastasis. (2005)
  • Author(s): Yoneda T, Hiraga T.
  • Journal Title: Biochem Biophys Res Commun 328 Pages: 679-687
  • Peer Reviewed
• [Journal Article] Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model. (2005)
  • Author(s): Hiraga T, Hata K, Ikeda F, Kitagaki J, Fujimoto-Ouchi K, Tanaka Y, Yoneda T.
  • Journal Title: Oncol Report 14 Pages: 695-699
  • Peer Reviewed
• [Journal Article] Suppression by incadronate of invasion and growth of A-375 human melanoma in mandible in nude mice. (2005)
  • Author(s): Kitagawa Y, Hiraga T, Yura Y, Yoneda T.
  • Journal Title: Oncol Report 13 Pages: 211-216
  • Peer Reviewed
• [Journal Article] Hypercalcemia/Leukocytosis syndrome associated with lung cancer. (2004)
  • Author(s): Hiraki A, Ueoka H, Takata I, Gemba K, Bessho A, Segawa Y, Kiura K, Eguchi K, Yoneda T, Tanimoto M, Harada M
  • Journal Title: Lung Cancer 43 Pages: 301-307
  • Peer Reviewed
• [Journal Article] Bone sialoprotein promotes bone metastasis of a non-bone-seeking clone of human breast cancer cells. (2004)
  • Author(s): Zhang J-H, Wang J, Tang J, Barnett B, Dickson J, Hashimoto N, Williams PJ, Ma W, Zheng W, Yoneda T, Pageau S, Chen J
  • Journal Title: Anticancer Res 24(3a) Pages: 1361-1368
  • Peer Reviewed
• [Journal Article] Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. (2004)
  • Author(s): Hiraga T, Williams PJ, Ueda A, Tamura D, Yoneda T
  • Journal Title: Clin Cancer Res 10 Pages: 4559-4567
  • Peer Reviewed
• [Journal Article] Anti-α4 integrin antibody suppresses the development of multiple myeloma and associated with osteoclastic osteolysis. (2004)
  • Author(s): Mori Y, Shimizu N, Dallas M, Niewolna M, Story B, Williams PJ, Mundy GR, Yoneda T
  • Journal Title: Blood 104 Pages: 2149-2154
  • Peer Reviewed
• [Presentation] a3 Isoform of V-ATPase is critical to bone metastases. (2009)
  • Author(s): Nishisho M, Yoneda T, et al.
  • Organizer: アメリカ骨代謝学会
  • Place of Presentation: デンバー
  • Year and Date: 2009-09-13
• [Presentation] STAT3の活性化によるレプチンの産生増加は前立腺がんの造骨性転移を促進する. (2008)
  • Author(s): 王麗楊, 米田俊之,, ら5名
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-31
• [Book] 生命歯科医学のカッティング・エッジ (2008)
  • Author(s): 米田俊之
  • Total Pages: 287
  • Publisher: 大阪大学出版会