2009 Fiscal Year Final Research Report
Cell Polarity Signaling and Cancer
| Project/Area Number |
17014076
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
OHNO Shigeo Yokohama City University, 医学研究科, 教授 (10142027)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Atsushi 横浜市立大学, 大学院・医学研究科, 准教授 (00264606)
AKIMOTO Kazunori 横浜市立大学, 医学部, 助教 (70285104)
HIROSE Tomonori 横浜市立大学, 医学部, 助教 (20381668)
MIZUNO Keiko (90221803)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Keywords | aPKC / MDCK細胞 / PAR-3 / PAR-6 / 上皮細胞 / 前立腺がん / 胃がん / 乳がん |
|---|
| Research Abstract |
A series of experiments focusing on the aPKC-PAR complex revealed (1) the new role of PAR1 on the recruitment and organization of extracellular laminin through utrophin/dystroglucan complex. We have also identified ASPP2, known as a mediator of apoptic function of p53, as a partner of the aPKC-PAR complex. (2) In mammary epithelial stem/progenitor cells the aPKC-ErbB2 pathway negatively regulates proliferation. (3) Relationships between aPKC overexpression and the recurrence of prostate cancer, metastasis of stomach cancer, and grade of mammary cancer. Intensive studies on prostate cancer cells revealed the aPKC-IL6 axis. These results reinforce the importance of the understanding of cell polarity for the understanding of cancer cells.
|
Research Products
(34 results)
-
-
-
[Journal Article] High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence.2009
Author(s)
Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Endo I, Nagashima Y, Ohno S
-
Journal Title
Ann Surg Oncol 17(1)
Pages: 81-88
-
-
-
-
-
[Journal Article] SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.2009
Author(s)
Yamashita A, Izumi N, Kashima I, Ohnishi T, Saari B, Katsuhata Y, Muramatsu R, Morita T, Iwamatsu A, Hachiya T, Kurata R, Hirano H, Anderson P, Ohno S
-
Journal Title
Genes Dev. 23(9)
Pages: 1091-1105
-
[Journal Article] An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms.2009
Author(s)
Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S
-
Journal Title
PLoS ONE 4(1)
Pages: e4194
-
-
[Journal Article] The over- expression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors.2008
Author(s)
Kojima Y, Akimoto K, Nagashima Y, Ishiguro H, Shirai S, Chishima T, Ichikawa Y, Ishikawa T, Sasaki T, Kubota Y, Inayama Y, Aoki I, Ohno S, Shimada H
-
Journal Title
Hum Pathol 39(6)
Pages: 824-831
-
-
-
-
-
-
-
[Journal Article] Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.2007
Author(s)
Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, Ohno S, Hatakeyama M
-
Journal Title
Nature 447(7142)
Pages: 330-333
-
-
-
-
-
-
-
-
-
-
-
[Remarks] 新聞報道
-
[Remarks] 2010.4.13 経産業新聞、DNA損傷防ぐ仕組み解明
-
[Remarks] 2009.10.20 日経産業新聞、前立腺がん再発関連の遺伝子発見
-
[Remarks] 2009.2.22 読売新聞、腎糸球体の血液ろ過膜機能維持に新たな機構
-
-
