2009 Fiscal Year Final Research Report
Mechanisms regulating cell adhesion activities in tumor progression
| Project/Area Number |
17014083
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka Bioscience Institute |
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Principal Investigator |
SABE Hisataka Osaka Bioscience Institute, 大学院・医学研究科, 教授 (40187282)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 癌 / 浸潤 / 転移 / 細胞接着 / E-カドヘリン / インテグリン / Arf6 / シグナル伝達 |
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| Research Abstract |
Most malignant human tumors are epithelial cell origin. The basic fear of such tumors are based on their invasion and metastasis. Activation of integrins and inactivation of E-cadherin are hallmark characteristics for such invasive and metastatic properties. Here our purpose is to understanding the underlying molecular mechanisms for integrin activation and E-cadherin inactivation in the malignant development of tumor cells.
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Research Products
(38 results)
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[Journal Article] Zyxin mediates actin fiber reorganization nepithelial-mesenchymal transition and contributes to endocardial morphogenesis.2009
Author(s)
Mori M., Nakagami H., Koibuchi N., Miura K., Takami Y., Koriyama H., Hayashi H., Sabe H., Mochizuki N., Morishita R., Kaneda Y.
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Journal Title
Mol Biol Cell. 20
Pages: 3115-3124
Peer Reviewed
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[Journal Article] GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.2008
Author(s)
Morishige M., Hashimoto S., Ogawa E., Toda Y., Kotani H., Hirose M., Wei S., Hashimoto A., Yamada A., Yano H., Mazaki Y., Kodama H., Nio Y., Manabe T., Wada H., Kobayashi H., Sabe H.
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Journal Title
Nat Cell Biol. 10
Pages: 85-92
Peer Reviewed
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[Journal Article] Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.2006
Author(s)
Mazaki Y., Hashimoto S., Tsujimura T., Morishige M., Hashimoto A., Aritake K., Yamada A., Nam JM., Kiyonari H., Nakao K., Sabe H.
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Journal Title
Nat Immunol 7
Pages: 724-731
Peer Reviewed
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[Journal Article] Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.2006
Author(s)
Hashimoto S., Hirose M., Hashimoto A., Morishige M., Yamada A., Hosaka H., Akagi K., Ogawa E., Oneyama C., Agatsuma T., Okada M., Kobayashi H., Wada H., Nakano H., Ikegami T., Nakagawa A., Sabe H.
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Journal Title
Proc Natl Acad Sci U S A. 103
Pages: 7036-7041
Peer Reviewed
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[Journal Article] Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.2005
Author(s)
Onodera Y., Hashimoto S., Hashimoto A., Morishige M., Mazaki Y., Yamada A., Ogawa E., Adachi M., Sakurai T., Manabe T., Wada H., Matsuura N., Sabe H.
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Journal Title
EMBO J. 24
Pages: 963-973
Peer Reviewed
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