2009 Fiscal Year Final Research Report
Regulation of adhesion and migration of cancer cells by tyrosine kinase signaling
| Project/Area Number |
17014086
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
SAKAI Ryuichi National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所・細胞増殖因子研究部, 部長 (40215603)
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| Project Period (FY) |
2005 – 2009
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| Keywords | 転移・浸潤 / 足場非依存性 / Srcファミリーキナーゼ / CDCP1 / チロシンリン酸化 / Ossa / 酸化ストレス / スキルス胃がん |
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| Research Abstract |
In this project, numbers of proteins which are tyrosine-phosphorylated during the malignant progression of cancers were identified and functional analysis was performed. CDCP1, which was identified as a molecule involved in anchorage independent growth of cancer cells, also regulates cell migration and matrix degradation. A subset of lung and pancreatic tumors which has high levels of CDCP1 expression showed statistically worse prognosis than that with low levels of CDCP1 expression in clinical samples. It was demonstrated that ephrin-B1 controls multiple factors associated with metastasis such as cell-cell interaction and migration, and peptides which block ephrin-B1 signaling suppressed the peritoneal dissemination of gastric cancers in vivo. A novel protein Ossa identified as a molecule tyrosine-phosphorylated during peritoneal dissemination was shown to be essential for acquireing resistance to the oxidative stress-induced apoptosis.
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[Journal Article] A novel RNA-binding protein, Ossa/C9orf10 regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis.2009
Author(s)
Tanaka, M., Sasaki, K., Kamata, R., Hoshino, Y., Yanagihara, K., Sakai, R.
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Journal Title
Mol. Cell. Biol. 2009 29
Pages: 402-413
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[Journal Article] CUB-domain containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma.2008
Author(s)
Uekita, T., Tanaka, M., Takigahira, M., Miyazawa, Y., Nakanishi, Y., Kanai, Y., Yanagihara, K., Sakai, R.
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Journal Title
Am. J. Pathol. 172
Pages: 1729-1739
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[Journal Article] CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma2007
Author(s)
Uekita, T., Jia, L., Narisawa-Saito, M., Yokota, J., Kiyono, T., Sakai, R.
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Journal Title
Mol. Cell. Biol. 27
Pages: 7649-7660
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[Journal Article] Force sensing by mechanical extension of the Src family kinase substrate p130Cas.2006
Author(s)
Sawada, Y., Tamada, M., Dubrin-Thaler, B., Cherniavskaya, O., Sakai, R., Tanaka S., Sheetz M.P.
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Journal Title
Cell 127
Pages: 1015-1026
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