New avenue for molecular diagnosis of pancreatic and gynecological cancers

2009 Fiscal Year Final Research Report

• Project/Area Number: 17015003
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: HORII Akira Tohoku University, 大学院・医学系研究科, 教授 (40249983)
• Co-Investigator(Kenkyū-buntansha): SUNAMURA Makoto 東北大学, 大学院・医学系研究科, 非常勤講師 (10201584) ; YAEGASHI Nobuo 東北大学, 大学院・医学系研究科, 教授 (00241597) ; EGAWA Shinichi 東北大学, 大学院・医学系研究科, 准教授 (00270679)
• Co-Investigator(Renkei-kenkyūsha): SUNAMURA Makoto 東北大学, 大学院・医学系研究科, 非常勤講師 (10201584) ; YAEGASHI Nobuo 東北大学, 大学院・医学系研究科, 教授 (00241597) ; EGAWA Shinichi 東北大学, 大学院・医学系研究科, 准教授 (00270679)
• Project Period (FY): 2005 – 2009
• Keywords: 膵癌 / 婦人科癌 / 個別化医療 / RNAi / epigenetic / がん遺伝子 / がん抑制遺伝子

Research Abstract

Overexpression of the AURKA and S100A4 genes and expressional suppression of the DUSP6 gene functions as the drivers of pancreatic carcinogenesis. In addition, knockdown of AURKA caused synergistic chemosensitivity with taxane. Restoration of DUSP6 caused suppression of AURKA via suppression of ETS-2. Further, expressional link of PRDM2 and VASH1 with S100A4 was found. Both MAPK and PI3K cascades are keys in endometrial carcinogenesis and regulation of these cascade are potentially useful for clinical managements.

Research Products

• [Journal Article] 膵臓癌の診療-基礎から臨床へ- (2010)
  • Author(s): 堀井明
  • Journal Title: 日本医事新報 (印刷中)
• [Journal Article] RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells. (2009)
  • Author(s): Tabata T, Tsukamoto N, Imani Fooladi AA, Yamanaka S, Furukawa T, Ishida M, Sato D, Gu Z, Nagase H, Egawa S, Sunamura M, Horii A
  • Journal Title: Biochem Biophys Res Commun 390 Pages: 475-480
  • Peer Reviewed
• [Journal Article] LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells. (2009)
  • Author(s): Unno J, Satoh K, Hirota M, Kanno A, Hamada S, Ito H, Masamune A, Tsukamoto N, Motoi F, Egawa S, Unno M, Horii A, Shimosegawa T
  • Journal Title: Int J Oncol 35 Pages: 813-821
  • Peer Reviewed
• [Journal Article] siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis. (2009)
  • Author(s): Kaneko N, Miura K, Gu Z, Karasawa H, Ohnuma S, Sasaki H, Tsukamoto N, Yokoyama S, Yamamura A, Nagase H, Shibata C, Sasaki I, Horii A
  • Journal Title: Biochem Biophys Res Commun 390 Pages: 1235-1240
  • Peer Reviewed
• [Journal Article] Methyl-CpG targeted recruitment of p300 reactivates tumor suppressor genes in human cancer cells. (2009)
  • Author(s): Fukushige S, Kondo E, Horii A
  • Journal Title: Biochem Biophys Res Commun 379 Pages: 1021-1026
  • Peer Reviewed
• [Journal Article] Transcriptional silencing of ETS-1 efficiently suppresses angiogenesis of pancreatic cancer. (2009)
  • Author(s): Lefter LP, Dima S, Sunamura M, Furukawa T, Sato Y, Abe M, Chivu M, Popescu I, Horii A
  • Journal Title: Cancer Gene Ther 16 Pages: 137-148
  • Peer Reviewed
• [Journal Article] Cancer-associated splicing variants of the CDCA1 and MSMB genes expressed in cancer cell lines and surgically resected stomach cancer tissues. (2009)
  • Author(s): Ohnuma S, Miura K, Horii A, Fujibuchi W, Kaneko N, Gotoh O, Nagasaki H, Mizoi T, Tsukamoto N, Kobayashi T, Kinouchi M, Okabe M, Sasaki H, Shiiba K, Miyagawa K, Sasaki I
  • Journal Title: Surgery 145 Pages: 57-68
  • Peer Reviewed
• [Journal Article] 膵癌細胞の悪性度の解明と新たな治療法開発の試み (2009)
  • Author(s): 砂村眞琴, 浅野武彦, 堀井明
  • Journal Title: Frontiers in Gastroenterology 14 Pages: 39-48
• [Journal Article] Methyl-CpG targeted transcriptional activation allows re-expression of tumor suppressor genes in human cancer cells. (2008)
  • Author(s): Fukushige S, Kondo E, Horii A
  • Journal Title: Biochem Biophys Res Commun 377 Pages: 600-605
  • Peer Reviewed
• [Journal Article] Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells. (2008)
  • Author(s): Furukawa T, Tanji E, Xu S, Horii A
  • Journal Title: Biochem Biophys Res Commun 377 Pages: 317-320
  • Peer Reviewed
• [Journal Article] Identification of SMURF1 as a possible target for 7q21. 3-22. 1 amplification detected in pancreatic cancer cell line by in-house array-based comparative genomic hybridization. (2008)
  • Author(s): Suzuki A, Shibata T, Shimada Y, Murakami Y, Horii A, Shiratori K, Hirohashi S, Inazawa J, Imoto I
  • Journal Title: Cancer Sci 99 Pages: 986-994
  • Peer Reviewed
• [Journal Article] Synchronous and metachronous extra-pancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas. (2008)
  • Author(s): Ishida M, Egawa S, Kawaguchi K, Aoki T, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Katayose Y, Sunamura M, Unno M, Moriya T, Horii A, Furukawa T
  • Journal Title: Pancreatology 8 Pages: 577-582
  • Peer Reviewed
• [Journal Article] The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer. (2008)
  • Author(s): Ishida M, Sunamura M, Furukawa T, Lefter LP, Morita R, Akada M, Egawa S, Unno M, Horii A
  • Journal Title: Dig Dis Sci 53 Pages: 2576-2582
  • Peer Reviewed
• [Journal Article] The FBXW7 β-form is suppressed in human glioma cells. (2007)
  • Author(s): Gu Z, Inomata K, Ishizawa K, Horii A
  • Journal Title: Biochem Biophys Res Commun 354 Pages: 992-998
  • Peer Reviewed
• [Journal Article] Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis. (2007)
  • Author(s): Ishida M, Sunamura M, Furukawa T, Akada M, Fujimura H, Shibuya E, Egawa S, Unno M, Horii A
  • Journal Title: World J Gastroenterol 13 Pages: 4593-4597
  • Peer Reviewed
• [Journal Article] Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasm of the pancreas. (2007)
  • Author(s): Ishida M, Egawa S, Aoki T, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Sunamura M, Unno M, Moriya T, Horii A, Furukawa T
  • Journal Title: Pancreas 35 Pages: 348-352
  • Peer Reviewed
• [Journal Article] A new 10-minute ligation method using a modified buffer system with a very low amount of T4 DNA ligase: the "Coffee Break Ligation" technique. (2007)
  • Author(s): Yoshino Y, Ishida M, Horii A
  • Journal Title: Biothchnol Lett 29 Pages: 1557-1560
  • Peer Reviewed
• [Journal Article] RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression. (2006)
  • Author(s): Fukushige S, Kondo E, Gu Z, Suzuki H, Horii A
  • Journal Title: Biochem Biophys Res Commun 351 Pages: 85-92
  • Peer Reviewed
• [Journal Article] AURKA is a major downstream target of MAPK1/ERK2 in pancreatic cancer. (2006)
  • Author(s): Furukawa T, Kanai N, Shiwaku HO, Soga N, Uehara A, Horii A
  • Journal Title: Oncogene 25 Pages: 4831-4839
  • Peer Reviewed
• [Journal Article] Genome-wide profiling of promoter methylation in human. (2006)
  • Author(s): Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T, Sasaki H
  • Journal Title: Oncogene 25 Pages: 3059-3064
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of pancreatic carcinogenesis. (2006)
  • Author(s): Furukawa T, Sunamura M, Horii A
  • Journal Title: Cancer Sci 97 Pages: 1-7
  • Peer Reviewed
• [Journal Article] 膵癌の遺伝子診断 (2006)
  • Author(s): 堀井明
  • Journal Title: 臨床消化器内科 21 Pages: 1737-1745
• [Journal Article] Exploration of genetic alterations in human endometrial cancer and melanoma: Distinct tumorigenic pathways that share a frequent abnormal PI3K/AKT cascade. (2005)
  • Author(s): Ogawa K, Sun C, Horii A
  • Journal Title: Oncol Rep 14 Pages: 1481-1485
  • Peer Reviewed
• [Journal Article] Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: A consensus study (2005)
  • Author(s): Furukawa T, Kloppel G, Adsay NV, Albores-Saavedra J, Fukushima N, Horii A, Hruban RH, Kato Y, Klimstra DS, Longnecker DS, Luttges J, Offerhaus GJA, Shimizu M, Sunamura M, Suriawinata A, Takaori K, Yonezawa S
  • Journal Title: Virchows Archiv 447 Pages: 794-799
  • Peer Reviewed
• [Journal Article] Mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in Japanese patients with pancreatitis (2005)
  • Author(s): Kume K, Masamune A, Mizutamari H, Kaneko K, Kikuta K, Satoh M, Satoh K, Kimura K, Suzuki N, Nagasaki Y, Horii A, Shimosegawa T
  • Journal Title: Pancreatology 5 Pages: 354-360
  • Peer Reviewed
• [Journal Article] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. (2005)
  • Author(s): Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y, Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y
  • Journal Title: Int J Cancer 116 Pages: 925-933
  • Peer Reviewed
• [Journal Article] The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16INK4a and MLH1 genes. (2005)
  • Author(s): Kondo E, Gu Z, Horii A, Fukushige S
  • Journal Title: Mol Cell Biol 25 Pages: 4388-4396
  • Peer Reviewed
• [Journal Article] Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. (2005)
  • Author(s): Xu S, Furukawa T, Kanai N, Sunamura M, Horii A
  • Journal Title: J Hum Genet 50 Pages: 159-167
  • Peer Reviewed
• [Presentation] メチル化で発現抑制された遺伝子を特定する新規の方法「MeTA」の膵癌解析への応用 (2010)
  • Author(s): 清水秀幸、福重真一、堀井明
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100427-20100429
• [Presentation] S100A4 regulates tumor growth, motility, and invasion in pancreatic cancer. (2010)
  • Author(s): Sekine H, Tabata T, Tsukamoto N, Yamamura A, Abe K, Yoshino Y, Sato K, Chen N, Umetsu Y, Sato D, Gu Z, Fukushige S, Shima K, Motoi F, Egawa S, Sunamura M, Horii A
  • Organizer: 101st Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Washington DC
  • Year and Date: 20100417-20100421
• [Presentation] Expression of the N-myc downstream-regulated gene 2 (NDRG2) is frequently suppressed by promoter hypermethylation in human gastrointestinal and pancreatic cancers. (2010)
  • Author(s): Yamamura A, Miura K, Karasawa H, Abe K, Mizuguchi Y, Jin G, Gu Z, Fukushige S, Kaneko N, Kinouchi M, Ando T, Yazaki N, Tanaka N, Sase T, Shibata C, Sasaki I, Horii A
  • Organizer: 101st Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Washington DC
  • Year and Date: 20100417-20100421
• [Presentation] Identification of novel targets for aberrant methylation in pancreatic cancer by a newly developed method "methyl-CpG targeted transcriptional activation (MeTA). " (2010)
  • Author(s): Fukushige S, Shimizu H, Sato Y, Horii A
  • Organizer: 101st Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Washington DC
  • Year and Date: 20100417-20100421
• [Presentation] Identification of epigenetically silenced genes by the novel "methyl-CpG targeted transcriptional activation" method in human pancreatic cancer. (2010)
  • Author(s): Shimizu H, Sato Y, Horii A, Fukushige S
  • Organizer: 8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
  • Place of Presentation: Waikoloa, HI
  • Year and Date: 20100205-20100210
• [Presentation] S100A4 regulates cell growth and motility in pancreatic cancer cells. (2009)
  • Author(s): 関根均、塚本信和、田畑孝洋、吉野優樹、梅津有紀子、Zhaodi Gu、佐藤大亮、嶋健太郎、福重真一、元井冬彦、江川新一、砂村眞琴、堀井明
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] メチルCpG配列を標的とする転写再活性化による膵がんにおいてエピジェネティックに転写抑制された遺伝子の同定 (2009)
  • Author(s): 福重真一、清水秀幸、堀井明
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] メチルCpG配列を標的とする転写再活性化と遺伝子発現マイクロアレイの組合せは、DNAメチル化によってエピジェネティックに転写抑制された遺伝子を同定する新しいアプローチを提供する (2009)
  • Author(s): 佐藤裕子、堀井明、福重真一
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] NDRG2 is a novel tumor suppressor gene which expression reduced by promoter hypermethylation in digestive cancer. (2009)
  • Author(s): 山村明寛、三浦康、安藤敏典、矢崎伸樹、田中直樹、唐澤秀明、佐瀬友彦、福重真一、Zhaodi Gu、森下和広、佐々木巖、堀井明
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] メタボローム解析を用いた膵癌個別化療法の展望 (2009)
  • Author(s): 砂村眞琴、紙健次郎、石田晶玄、堀井明、浅野武秀、曽我朋義
  • Organizer: 第40回日本膵臓学会大会
  • Place of Presentation: 東京
  • Year and Date: 20090730-20090731
• [Presentation] Knockdown of S100A4 causes suppression of cell growth and motility in pancreatic cancer cells. (2008)
  • Author(s): Tsukamoto N, Tabata T, Gu Z, Yokoyama S, Kaneko N, Abe H,. Hayashi H,. Egawa S, Unno M, Horii A
  • Organizer: 39th American Pancreatic Association
  • Place of Presentation: Chicago
  • Year and Date: 20081106-20081107
• [Presentation] Methyl-CpG targeted p300 recruitment reactivates the expression of epigenetically silenced tumor suppressor genes. (2008)
  • Author(s): Fukushige S, Horii A
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] Knockdown of S100A4 causes suppression of cell growth and motility in pancreatic cancer cells. (2008)
  • Author(s): Tsukamoto N, Tabata T, Gu Z, Yokoyama S, Kaneko N, Furukawa T, Sunamura M, Ishida M, Otsuka H, Motoi F, Egawa S, Unno M, Horii A
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] Identification and characterization of a novel tumor suppressor gene on chromosome arm 18q in human pancreatic cancer. (2008)
  • Author(s): Yokoyama S, Ochiya T, Ishida M, Tsukamoto N, Kaneko N, Furukawa T, Sunamura M, Otsuka H, Motoi F, Egawa S, Unno M, Horii A
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] Controlling the tumor progression through knockdown of S100A4 in pancreatic cancer. (2008)
  • Author(s): Gu Z, Tsukamoto N, Tabata T, Sunamura M, Horii A
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] Elucidation of S100A4, one of the strong candidates for molecular target therapy in pancreatic cancer. (2008)
  • Author(s): Gu Z, Tsukamoto N, Tabata T, Sato D, Horii A
  • Organizer: 99th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: San Diego, CA
  • Year and Date: 20080412-20080416
• [Presentation] がん抑制遺伝子のエピジェネティックサイレンシングはヒストン修飾の改変によって再活性化される (2007)
  • Author(s): 福重真一, 近藤恵美子, 堀井明
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20071211-20071215
• [Presentation] Changes in histone modifications reactivate the expression of epigenetically silenced tumor suppressor genes in cancer cells. (2007)
  • Author(s): Fukushige S, Kondo E, Horii A
  • Organizer: 57th Annual Meeting of the American Society of Human Genetics
  • Place of Presentation: San Diego, CA
  • Year and Date: 20071023-20071027
• [Presentation] The chemosensitivity of 5-FU in human pancreatic cancer cell lines after inhibition of DPD by CDHP and siRNA. (2007)
  • Author(s): Ishida M, Chung C-W, Motoi F, Egawa S, Sunamura M, Unno M, Horii A
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-20071005
• [Presentation] Knockdown of S100A4 causes suppression of cell growth and motility in pancreatic cancer cells. (2007)
  • Author(s): Tsukamoto N, Tabata T, Furukawa T, Sunamura M, Ishida M, Egawa S, Unnom, Horii A
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-20071005
• [Presentation] Development of a molecular target therapy using AKT1 in endometrial cancer. (2007)
  • Author(s): Inomata K, Gu Z, Ogawa K, Horii A
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-20071005
• [Presentation] Knockdown of S100A4 causes suppression of cell growth and motility in pancreatic cancer cells. (2007)
  • Author(s): Tabata T, Sato D, Sunamura S, Furukawa T, Ishida M, Sunamura M, Horii A
  • Organizer: 98th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Los Angeles, CA
  • Year and Date: 20070414-20070418
• [Presentation] 膵癌の分子標的治療法の開発 (2006)
  • Author(s): 堀井明
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20060928-20060930
• [Presentation] メチルCpG結合蛋白MBD2、MBD4を介した転写抑制におけるRET finger proteinの役割 (2006)
  • Author(s): 近藤恵美子、Zhaodi Gu、堀井明、福重真一
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20060928-20060930
• [Presentation] 各種ヒトがんにおける候補癌抑制遺伝子FBXW7の異常の検討 (2006)
  • Author(s): Zhaodi Gu、堀井明
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20060928-20060930
• [Presentation] 膵癌におけるS100A4を分子標的とした治療法の開発 (2006)
  • Author(s): 田畑孝洋、堀井明
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20060928-20060930
• [Presentation] ヒト卵巣癌における新たな分子標的治療の候補としてのAurora-AのRNA干渉法による解析 (2006)
  • Author(s): 孫春蘭、堀井明
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20060928-20060930
• [Presentation] Ret finger protein mediates MBD2- and MBD4-dependent transcriptional repression. (2006)
  • Author(s): Fukushige S, Gu Z, Kondo E, Horii A
  • Organizer: 97th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Washington DC
  • Year and Date: 20060401-20060405
• [Presentation] AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer. (2006)
  • Author(s): Furukawa T, Horii A
  • Organizer: 97th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Washington DC
  • Year and Date: 20060401-20060405
• [Presentation] Elucidation of potential therapeutic possibility of siRNA for human cancer. (2006)
  • Author(s): Horii A
  • Organizer: 11th International Charles Heidelberger Symposium on Cancer Research
  • Place of Presentation: Phitsanulok, Thailand
  • Year and Date: 20060126-20060129
• [Presentation] 膵の発癌推進に働くAurora-A kinaseの高発現は予後に影響する (2005)
  • Author(s): 石田晶玄、古川徹、江川新一、元井冬彦、金井菜緒美、畠達夫、堀井明、砂村眞琴
  • Organizer: 第64回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20050914-20050916
• [Presentation] 膵癌における分子標的治療候補としてのS100A4のRNAi法によるノックダウンの効果 (2005)
  • Author(s): 田畑孝洋、山中澄隆、古川徹、堀井明
  • Organizer: 第64回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20050914-20050916
• [Presentation] Cre-lox遺伝子挿入系を用いたp53ミスセンス変異の解析 (2005)
  • Author(s): 近藤恵美子、堀井明、福重真一
  • Organizer: 第64回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20050914-20050916
• [Presentation] 膵臓癌におけるMAPK1/ERK2の下流標的遺伝子の網羅的解析 (2005)
  • Author(s): 古川徹、金井奈緒美、塩飽浩美、堀井明
  • Organizer: 第64回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20050914-20050916
• [Presentation] 癌関連遺伝子の高度メチル化プロモーターにおけるMBD4蛋白の役割 (2005)
  • Author(s): 福重真一、近藤恵美子、Zhaodi Gu、堀井明
  • Organizer: 第64回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20050914-20050916
• [Book] がんの分子標的治療 (2008)
  • Author(s): 堀井明膵臓がん鶴尾隆
  • Total Pages: 403-408
  • Publisher: 南山堂
• [Book] The role of DUSP6/MKP-3 in pancreatic carcinoma.(In: Hayat MA (ed. ), Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3: Molecular genetics, liver carcinoma, and pancreatic carcinoma) (2005)
  • Author(s): Furukawa T, Horii A
  • Total Pages: 335-339
  • Publisher: Elsevier
• [Remarks]
  • URL: http://www.med.tohoku.ac.jp/org/medical/13/index.html