2009 Fiscal Year Final Research Report
Development of new diagnostic and therapeutic approaches based on information of the human genome
| Project/Area Number |
17015009
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FURUKAWA Yoichi The University of Tokyo, 医科学研究所, 教授 (20272560)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAMOTO Ryuji 東京大学, 医科学研究所, 助教 (80321800)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ゲノム / 癌 / マイクロアレイ / 診断 / 治療 |
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| Research Abstract |
Genome-wide gene expression profile analyses of human colorectal, hepatocellular, and gastric carcinomas have identified candidate genes for targeted cancer therapies against these tumors. Through the functional analyses of these genes, we have elucidated a part of mechanism(s) underlying these tumors, and obtained useful information for the development of the therapeutic approaches.
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[Journal Article] Deficiency of GMD leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling2009
Author(s)
Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E.
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Journal Title
Gastroenterology 137
Pages: 188-198
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